Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 3, 2010, Pages 758-763

  Szasz, Theodora ^a   Watts, Stephanie W ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALLOPURINOL; DEOXYCORTICOSTERONE ACETATE; OXONIC ACID; PROSTAGLANDIN F2 ALPHA; URIC ACID; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HYPERTENSION; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT; SYSTOLIC BLOOD PRESSURE; VASODILATATION; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; BLOTTING, WESTERN; DESOXYCORTICOSTERONE; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERTENSION; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE; URATE OXIDASE; URIC ACID; VASODILATOR AGENTS; XANTHINE OXIDASE;

EID: 77952393125     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.160184     Document Type: Article

References (34)

1. Becker BF (1993) Towards the physiological function of uric acid. Free Radic Biol Med 14:615-631.
2. Beckman JS and Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424-C1437.
3. Berry CE and Hare JM (2004) Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J Physiol 555:589-606. (Pubitemid 38404582)
4. Borges F, Fernandes E, and Roleira F (2002) Progress towards the discovery of xanthine oxidase inhibitors. Curr Med Chem 9:195-217. (Pubitemid 34436441)
5. Butler R, Morris AD, Belch JJ, Hill A, and Struthers AD (2000) Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 35:746-751. (Pubitemid 30165320)
6. Cai H and Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840-844.
7. Feig DI, Kang DH, and Johnson RJ (2008) Uric acid and cardiovascular risk. N Engl J Med 359:1811-1821.
8. Fridovich I (1965) The competitive inhibition of uricase by oxonate and by related derivatives of S-triazines. J Biol Chem 240:2491-2494.
9. Gao X, Belmadani S, Picchi A, Xu X, Potter BJ, Tewari-Singh N, Capobianco S, Chilian WM, and Zhang C (2007) Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115:245-254. (Pubitemid 46105724)
10. George J, Carr E, Davies J, Belch JJ, and Struthers A (2006) High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation 114:2508-2516. (Pubitemid 44901524)
11. Gersch C, Palii SP, Kim KM, Angerhofer A, Johnson RJ, and Henderson GN (2008) Inactivation of nitric oxide by uric acid. Nucleosides Nucleotides Nucleic Acids 27:967-978.
12. Heitzer T, Schlinzig T, Krohn K, Meinertz T, and Münzel T (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104:2673-2678. (Pubitemid 33108132)
13. Higashi Y, Sasaki S, Nakagawa K, Fukuda Y, Matsuura H, Oshima T, and Chayama K (2002) Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens 15:326-332. (Pubitemid 34408972)
14. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, and Mazzali M (2003) Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41:1183-1190.
15. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, Krotova K, Block ER, Prabhakar S, and Johnson RJ (2005) Hyperuricemia induces endothelial dysfunction. Kidney Int 67:1739-1742.
16. Kim SY, De Vera MA, and Choi HK (2008) Gout and mortality. Clin Exp Rheumatol 26:S115-S119.
17. Krishnan E, Kwoh CK, Schumacher HR, and Kuller L (2007) Hyperuricemia and incidence of hypertension among men without metabolic syndrome. Hypertension 49:298-303. (Pubitemid 46143005)
18. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, and Johnson RJ (2001) Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 38:1101-1106. (Pubitemid 34252813)
19. Mitchell BM, Dorrance AM, Ergul A, and Webb RC (2004) Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. J Cardiovasc Pharmacol 43:93-98. (Pubitemid 38032069)
20. Ozawa Y, Hayashi K, Kanda T, Homma K, Takamatsu I, Tatematsu S, Yoshioka K, Kumagai H, Wakino S, and Saruta T (2004) Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats. Nephrology (Carlton) 9:272-277. (Pubitemid 39576929)
21. Pacher P, Nivorozhkin A, and Szabó C (2006) Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 58:87-114. (Pubitemid 43316063)
22. Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, Mu W, Endou H, and Johnson RJ (2006) Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 17:1791-1795. (Pubitemid 44036162)
23. Schulz E, Jansen T, Wenzel P, Daiber A, and Münzel T (2008) Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 10:1115-1126. (Pubitemid 351451710)
24. Skinner KA, White CR, Patel R, Tan S, Barnes S, Kirk M, Darley-Usmar V, and Parks DA (1998) Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor. J Biol Chem 273:24491-24497. (Pubitemid 28454943)
25. So A (2008) Developments in the scientific and clinical understanding of gout. Arthritis Res Ther 10:221.
26. Suzuki H, DeLano FA, Parks DA, Jamshidi N, Granger DN, Ishii H, Suematsu M, Zweifach BW, and Schmid-Schönbein GW (1998) Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats. Proc Natl Acad Sci USA 95:4754-4759. (Pubitemid 28207986)
27. Szasz T, Thompson JM, and Watts SW (2008) A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase. Am J Physiol Heart Circ Physiol 295:H1341-H1350.
28. Touyz RM and Schiffrin EL (2004) Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 122:339-352.
29. Varela-Echavarría A, Montes de Oca-Luna R, and Barrera-Saldaña HA (1988) Uricase protein sequences: conserved during vertebrate evolution but absent in humans. FASEB J 2:3092-3096.
30. Viel EC, Benkirane K, Javeshghani D, Touyz RM, and Schiffrin EL (2008) Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 295:H281-H288.
31. Waring WS, McKnight JA, Webb DJ, and Maxwell SR (2006) Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers. Diabetes 55:3127-3132. (Pubitemid 44923652)
32. Waring WS, McKnight JA, Webb DJ, and Maxwell SR (2007) Lowering serum urate does not improve endothelial function in patients with type 2 diabetes. Diabetologia 50:2572-2579.
33. Yeldandi AV, Yeldandi V, Kumar S, Murthy CV, Wang XD, Alvares K, Rao MS, and Reddy JK (1991) Molecular evolution of the urate oxidase-encoding gene in hominoid primates: nonsense mutations. Gene 109:281-284.
34. Zheng JS, Yang XQ, Lookingland KJ, Fink GD, Hesslinger C, Kapatos G, Kovesdi I, and Chen AF (2003) Gene transfer of human guanosine 5′-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation 108:1238-1245. (Pubitemid 37099994)