Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope

British Journal of Dermatology

Volumn 152, Issue 1, 2005, Pages 146-149

  Sugiura, Hisashi ^a   Ebise, H ^b   Tazawa, T ^a   Tanaka, K ^a   Sugiura, Y ^c   Uehara, M ^a   Kikuchi, K ^b   Kimura, T ^b  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Atopic dermatitis; Cornified envelope; DNA microarray; Epidermal differentiation

Indexed keywords

FILAGGRIN; LORICRIN; PROTEIN S 100; PROTEIN S 100A8; PSORIASIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATOPY; CELL DIFFERENTIATION; CLINICAL ARTICLE; DNA MICROARRAY; FEMALE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE LOCATION; GENE OVEREXPRESSION; GENETIC DIFFERENCE; GENETIC IDENTIFICATION; GENETIC LINKAGE; HUMAN; KERATINIZATION; MALE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SKIN BIOPSY; ATOPIC DERMATITIS; CONTROLLED STUDY; DOWN REGULATION; ENVELOPE GENE; EPIDERMIS; GENE EXPRESSION; GENE LOCUS; HUMAN TISSUE; KERATINOCYTE; NUCLEOTIDE SEQUENCE; SKIN DEFECT; UPREGULATION;

ADULT; CELL DIFFERENTIATION; CHROMOSOMES, HUMAN, PAIR 1; DERMATITIS, ATOPIC; EPIDERMIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KERATINOCYTES; KERATINS; MALE; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 13244284843     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2005.06352.x     Document Type: Article

References (13)

1. Cookson WO, Ubhi B, Lawrence R et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nature Genet 2001; 27:372-3.
2. Bowcock AM, Shannon W, Du F et al. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 2001; 10:1783-805.
3. Williams HC, Burney PG, Pembroke AC, Hay RJ. The U.K. Working Party's diagnostic criteria for atopic dermatitis III. Independent hospital validation. Br J Dermatol 1994; 131:406-16.
4. Luo L, Salunga RC, Guo H et al. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nature Med 1999; 1:117-22.
5. Steinert PM, Marekov LN. The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of human epidermal cornified cell envelope. J Biol Chem 1995; 270:17702-11.
6. Olsen E, Rasmussen HH, Celis JE. Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Electrophoresis 1995; 16:2241-8.
7. Fuchs E. Epidermal differentiation: the bare essentials. J Cell Biol 1990; 111:2807-12.
8. Pol A, Pfundt R, Zeeuwen P et al. Transcriptional regulation of the elafin gene in human keratinocytes. J Invest Dermatol 2003; 120:301-7.
9. Dinulos JGH, Mentele L, Fredericks LP et al. Keratinocyte expression of human β-defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diagn Lab Immunol 2003; 10:161-6.
10. Ong PY, Ohtake T, Brandt C et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002; 347:1151-60.
11. Nomura I, Gao B, Boguniewicz M et al. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J Allergy Clin Immunol 2003; 112:1195-202.
12. Nakane H, Ishida-Yamamoto A, Takahashi H, Iizuka H. Elafin, a secretory protein, is cross-linked into the cornified cell envelopes from the inside of psoriatic keratinocytes. J Invest Dermatol 2002; 119:50-5.
13. Heizmann CW, Fritz G, Schaefer BW. S100 proteins: structure, functions and pathology. Front Biosci 2002; 7:1356-68.