Hepatic transcriptional analysis in rats treated with Cassia occidentalis seed: Involvement of oxidative stress and impairment in xenobiotic metabolism as a putative mechanism of toxicity

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 273-283

  Panigrahi, Gati Krushna ^a,d   Yadav, Ashish ^a   Yadav, Anuradha ^b   Ansari, Kausar M ^a   Chaturvedi, Rajnish K ^b   Vashistha, Vipin M ^c   Raisuddin, S ^d   Das, Mukul ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b CSIR IITR   (India)

^c Mangla Hospital and Research Centre   (India)

^d HAMDARD UNIVERSITY   (India)

Author keywords

Cassia occidentalis seed; Children; Microarray; Oxidative stress; Xenobiotic metabolism

Indexed keywords

AKT1 PROTEIN; ANTIOXIDANT; CATALASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 6; LIPID; MESSENGER RNA; PROTEIN BAX; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE 1; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ACUTE TOXICITY; ADULT; ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOHYDRATE METABOLISM; CELL CYCLE; CONTROLLED STUDY; EXPOSURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER TOXICITY; MODULATION; NONHUMAN; OXIDATIVE STRESS; PLANT SEED; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SENNA OCCIDENTALIS; VALIDATION PROCESS; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

CASSIA OCCIDENTALIS SEED; CHILDREN; MICROARRAY; OXIDATIVE STRESS; XENOBIOTIC METABOLISM;

ANIMALS; CASSIA; CYTOCHROME P-450 ENZYME SYSTEM; INDICATORS AND REAGENTS; ISOENZYMES; LIPID PEROXIDATION; LIVER; MALONDIALDEHYDE; MICROARRAY ANALYSIS; MIXED FUNCTION OXYGENASES; OXIDATIVE STRESS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SEEDS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; XENOBIOTICS;

EID: 84903719215     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.06.037     Document Type: Article

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