Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease

Experimental and Molecular Pathology

Volumn 90, Issue 1, 2011, Pages 123-130

  Bardag Gorce, Fawzia ^a   Oliva, Joan ^a   Lin, Andrew ^a   Li, Jun ^a   French, Barbara A ^a   French, Samuel W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Ethanol feeding; Oxidative stress; Proteasome inhibitor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; BORTEZOMIB; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PROTEASOME; PROTEASOME INHIBITOR; TRANSCRIPTION FACTOR NRF2;

ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION;

ANIMALS; BORONIC ACIDS; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHANOL; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TIME FACTORS; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 78650710068     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.10.013     Document Type: Article

References (44)

1. Bardag-Gorce F. Effects of ethanol on the proteasome interacting proteins. World J. Gastroenterol. 2010, 16(11):1349-1357.
2. Bardag-Gorce F., Yuan Q.X., Li J., French B.A., Fang C., Ingelman-Sundberg M., French S.W. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem. Biophys. Res. Commun. 2000, 279(1):23-29.
3. Bardag-Gorce F., Li J., French B.A., French S.W. Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341. Free Radic. Biol. Med. 2002, 32(1):17-21.
4. Bardag-Gorce F., French B.A., Nan L., Song H., Nguyen S.K., Yong H., Dedes J., French S.W. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp. Mol. Pathol. 2006, 3:191-201.
5. Bardag-Gorce F., French B.A., Dedes J., Li J., French S.W. Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Exp. Mol. Pathol. 2006, 80:241-251.
6. Bieler S., Meiners S., Stangl V., Pohl T., Stangl K. Comprehensive proteomic and transcriptomic analysis reveals early induction of a protective anti-oxidative stress response by low-dose proteasome inhibition. Proteomics 2009, 9(12):3257-3267.
7. Bousquet-Dubouch M.P., Nguen S., Bouyssié D., Burlet-Schiltz O., French S.W., Monsarrat B., Bardag-Gorce F. Chronic ethanol feeding affects proteasome-interacting proteins. Proteomics 2009, 9:3609-3622.
8. Cederbaum A. Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opin. Drug Metab. Toxicol. 2009, 5(10):1223-1244.
9. Das S.K., Vasudevan D.M. Alcohol-induced oxidative stress. Life Sci. 2007, 81(3):177-187.
10. de Vries H.E., Witte M., Hondius D., Rozemuller A.J., Drukarch B., Hoozemans J., van Horssen J. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?. Free Radic. Biol. Med. 2008, 45(10):1375-1383.
11. Dreiseitel A., Schreier P., Oehme A., Locher S., Rogler G., Piberger H., Hajak G., Sand P.G. Inhibition of proteasome activity by anthocyanins and anthocyanidins. Biochem. Biophys. Res. Commun. 2008, 372(1):57-61.
12. Du Z.X., Zhang H.Y., Meng X., Guan Y., Wang H.Q. Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells. BMC Cancer 2009, 56.
13. Fernández-Checa J.C., Kaplowitz N., García-Ruiz C., Colell A., Miranda M., Marí M., Ardite E., Morales A. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am. J. Physiol. 1997, 273(1):G7-G17.
14. Friguet B., Szweda L.I. Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein. FEBS Lett. 1997, 405:21-25.
15. Gilardini A., Marmiroli P., Cavaletti G. Proteasome inhibition: a promising strategy for treating cancer, but what about neurotoxicity?. Curr. Med. Chem. 2008, 15(29):3025-3035.
16. Gong P., Cederbaum A.I. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 2006, 43:144-153.
17. Hamilton A.L., Eder J.P., Pavlick A.C., Clark J.W., Liebes L., Garcia-Carbonero R., Chachoua A., Ryan D.P., Soma V., Farrell K., Kinchla N., Boyden J., Yee H., Zeleniuch-Jacquotte A., Wright J., Elliott P., Adams J., Muggia F.M. Proteasome inhibition with bortezomib (PS-341): a phase I study with pharmacodynamic end points using a day 1 and day 4 schedule in a 14-day cycle. J. Clin. Oncol. 2005, 23(25):6107-6116.
18. Harding H.P., Zhang Y., Zeng H., Novoa I., Lu P.D., Calfon M., Sadri N., Yun C., Popko C., Paules R., Stojdl D.F., Bell J.C., Hettmann T., Leiden J.M., Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 2003, 11(3):619-633.
19. Hill B.G., Haberzettl P., Ahmed Y., Srivastava S., Bhatnagar A. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem. J. 2008, 410(3):525-534.
20. Igarashi T., Izumi H., Uchiumi T., Nishio K., Arao T., Tanabe M., Uramoto H., Sugio K., Yasumoto K., Sasaguri Y., Wang K.Y., Otsuji Y., Kohon K. Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Oncogene 2007, 26:4749-4760.
21. Itoh K., Tong K.I., Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic. Biol. Med. 2004, 36:1208-1213.
22. Kobayashi M., Itoh K., Suzuki T., Osanai H., Nishikawa K., Katoh Y., Takagi Y., Yamamoto M. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 2002, 7:807-820.
23. Kobayashi A., Kang M.I., Watai Y., Tong K.I., Shibata T., Uchida K., Yamamoto M. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol. Cell. Biol. 2006, 1:221-229.
24. Kwak M.K., Itoh K., Yamamoto M., Kensler T.W. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the Nrf2 promoter. Mol. Cell. Biol. 2002, 22(9):2883-2892.
25. Lamle J., Marhenke S., Borlak J., von Wasielewski S., Eriksson C.J., Geffers R., Manns M.P., Yamamoto M., Vogel A. Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury induce in ALD. Gastroenterology 2008, 134:1159-1168.
26. Lee C.S., Tee L.Y., Warmke T., Vinjamoori A., Cai A., Fagan A.M., Snider B.J. A proteasomal stress response: pre-treatment with proteasome inhibitors increases proteasome activity and reduces neuronal vulnerability to oxidative injury. J. Neurochem. 2004, 91(4):996-1006.
27. Levine R.L., Williams J.A., Stadtman E.R., Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 1994, 233:346-357.
28. Li J., French B.A., Fu P., Bardag-Gorce F., French S.W. Mechanism of the alcohol cyclic pattern: role of catecholamines. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 285(2):G442-G448.
29. Li L., Chiu J.F., Kelsen A., Lu S.C., Fukagawa N.K. Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC). J. Cell. Biochem. 2009, 107:944-954.
30. Lorenz M., Wilck N., Meiners S., Ludwig A., Baumann G., Stangl K., Stangl V. Proteasome inhibition prevents experimentally-induced endothelial dysfunction. Life Sci. 2009, 84(25-26):929-934.
31. Marques C., Pereira P., Taylor A., Liang J.N., Reddy V.N., Szweda L., Shang F. Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J. 2004, 18:1424-1426.
32. Milani M., Rzymski T., Mellor H.R., Pike L., Bottini A., Generali D., Harris A.L. The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res. 2009, 69(10).
33. Nencioni A., Grünebach F., Patrone F., Ballestrero A., Brossart P. Proteasome inhibitors: antitumor effects and beyond. Leukemia 2007, 21:30-36.
34. Okada K., Wangpoengtrakul C., Osawa T., Toyokuni S., Tanaka K., Uchida K. 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules. J. Biol. Chem. 1999, 274:23787-23793.
35. Phillips J.B., Williams A.J., Adams J., Elliott P.J., Tortella F.C. Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia. Stroke 2000, 31:1686-1693.
36. Poss K.D., Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. PNAS 1997, 94(20):10925-10930.
37. Satoh T., Harada N., Hosoya T., Tohyama K., Yamamoto M., Itoh K. Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice. Biochem. Biophys. Res. Commun. 2009, 6(380(2)):298-302.
38. Sekhar K.R., Soltaninassab S.R., Borrelli M.J., Xu Z.Q., Meredith M.J., Domann F.E., Freeman M.L. Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for g-glutamylcysteine synthetase. Biochem. Biophys. Res. Comm. 2000, 270:311-317.
39. Stewart D., Killeen E., Naquin R., Alam S., Alam J. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J. Biol. Chem. 2003, 278(4):2396-2402.
40. Williams A.J., Dave J.R., Tortella F.C. Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration. Neurochem. Int. 2006, 49:106-112.
41. Yamamoto N., Sawada H., Izumi Y., Kume T., Katsuki T., Shimohama S., Akaike A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress. J. Biol. Chem. 2007, 282(7):4364-4372.
42. Yang X., Karsenty G. ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J. Biol. Chem. 2004, 279(45):47109-47114.
43. Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J.Y., Lu S.C. Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kB and AP-1. Mol. Cell. Biol. 2005, 14:5933-5946.
44. Zeng T., Zhang C.L., Zhu Z.P., Yu L.H., Zhao X.L., Xie K.Q. Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice. Toxicology 2008, 252(1-3):86-91.