Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 26, 2014, Pages 9603-9608

  Yanai, Ryoji ^a   Mulki, Lama ^a   Hasegawa, Eiichi ^a   Takeuchi, Kimio ^a   Sweigard, Harry ^a   Suzuki, Jun ^a   Gaissert, Philipp ^a   Vavvas, Demetrios G ^a   Sonoda, Koh Hei ^b   Rothe, Michael ^c   Schunck, Wolf Hagen ^d   Miller, Joan W ^a   Connor, Kip M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c LIPIDOMIX GMBH   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Adhesion molecules; Choroidal neovascularization; Epoxy metabolites; Immune cell recruitment; PPAR

Indexed keywords

17,18 EPOXYEICOSATETRAENOIC ACID; 19,20 EPOXYDOCOSAPENTAENOIC ACID; CYTOCHROME P450; DOCOSAHEXAENOIC ACID; ICOSANOID; ICOSAPENTAENOIC ACID; INTERCELLULAR ADHESION MOLECULE 1; OMEGA 3 FATTY ACID; PADGEM PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOROID; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; ENZYME METABOLISM; FAT INTAKE; FATTY ACID BLOOD LEVEL; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

ADHESION MOLECULES; CHOROIDAL NEOVASCULARIZATION; EPOXY-METABOLITES; IMMUNE CELL RECRUITMENT; PPARΓ;

ANIMALS; ARACHIDONIC ACIDS; CHOROIDAL NEOVASCULARIZATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACIDS, OMEGA-3; FLOW CYTOMETRY; FOOD, FORTIFIED; IMMUNOBLOTTING; LASER CAPTURE MICRODISSECTION; MACULAR DEGENERATION; MICE; PPAR GAMMA; REAL-TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY;

EID: 84903716802     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1401191111     Document Type: Article

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