Biological activity and migration of wear particles in the knee joint: An in vivo comparison of six different polyethylene materials

Journal of Materials Science: Materials in Medicine

Volumn 25, Issue 6, 2014, Pages 1599-1612

  Utzschneider, S ^a   Lorber, V ^a   Dedic, M ^a   Paulus, A C ^a   Schroder C ^a   Gottschalk, O ^a   Schmitt Sody, M ^a,b   Jansson, V ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Medical Park Chiemsee   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC COMPOUNDS; ARTHROPLASTY; BIOACTIVITY; BONE; CARTILAGE; KNEE PROSTHESES; MAMMALS; POLYETHYLENES; SUSPENSIONS (FLUIDS); TISSUE; WEAR OF MATERIALS;

ARTICULAR CARTILAGES; CROSS-LINKED MATERIALS; CROSSLINKED POLYETHYLENE; DISTRIBUTION OF PARTICLES; INFLAMMATORY REACTION; PARTICLE DISTRIBUTIONS; PARTICLE SUSPENSIONS; TOTAL KNEE ARTHROPLASTY;

JOINTS (ANATOMY);

INTERLEUKIN 1BETA; POLYETHYLENE; TUMOR NECROSIS FACTOR ALPHA; ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOLOGICAL ACTIVITY; BONE TISSUE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; FEMALE; FEMUR; HISTOPATHOLOGY; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; INTRAVITAL MICROSCOPY; KNEE PROSTHESIS; MECHANICAL STRESS; MICROSCOPY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROSTHESIS LOOSENING; PROTEIN EXPRESSION; SUBCHONDRAL BONE; SUSPENSION; SYNOVIUM; TIBIA; TISSUE DISTRIBUTION; TOTAL KNEE REPLACEMENT;

MUS;

ANIMALS; BIOCOMPATIBLE MATERIALS; EQUIPMENT FAILURE ANALYSIS; FEMALE; FOREIGN-BODY MIGRATION; KNEE JOINT; KNEE PROSTHESIS; MATERIALS TESTING; MICE; MICE, INBRED BALB C; PARTICLE SIZE; POLYETHYLENE; PROSTHESIS DESIGN;

EID: 84903710497     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-014-5176-6     Document Type: Article

References (53)

1. Asano T, Akagi M, Clarke IC, Masuda S, Ishii T, Nakamura T. Dose effects of cross-linking polyethylene for total knee arthroplasty on wear performance and mechanical properties. J Biomed Mater Res B Appl Biomater. 2007;83(2):615-22. doi:10.1002/jbm.b.30835. (Pubitemid 350005035)
2. Purdue PE, Koulouvaris P, Potter HG, Nestor BJ, Sculco TP. The cellular and molecular biology of periprosthetic osteolysis. Clin Orthop Relat Res. 2007;454:251-61. doi:10.1097/01.blo.0000238813.95035.1b. (Pubitemid 46074927)
3. Oral E, Wannomae KK, Hawkins N, Harris WH, Muratoglu OK. Alpha-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear. Biomaterials. 2004;25(24):5515-22. doi:10.1016/j.biomaterials.2003.12.048. (Pubitemid 38610190)
4. Fisher J, McEwen HM, Tipper JL, Galvin AL, Ingram J, Kamali A, et al. Wear, debris, and biologic activity of cross-linked polyethylene in the knee: benefits and potential concerns. Clin Orthop Relat Res. 2004;428:114-9. (Pubitemid 39506162)
5. Campbell P, Doorn P, Dorey F, Amstutz HC. Wear and morphology of ultra-high molecular weight polyethylene wear particles from total hip replacements. Proc Inst Mech Eng [H]. 1996;210(3):167-74. (Pubitemid 126759510)
6. Chang CH, Fang HW, Ho YC, Huang HT. Chondrocyte acting as phagocyte to internalize polyethylene wear particles and leads to the elevations of osteoarthritis associated NO and PGE2. Biochem Biophys Res Commun. 2008;369(3):884-8. doi:10.1016/j.bbrc.2008.02.123.
7. Castillo EC, Kouri JB. A new role for chondrocytes as non-professional phagocytes. An in vitro study. Microsc Res Tech. 2004;64(3):269-78. doi:10.1002/jemt.20080. (Pubitemid 39313873)
8. 14243 ISOI. Implants for surgery - wear of total knee-jointprostheses - part 1: loading and displacement parameters for wear-testing machines with load control and corresponding environmental conditions for tests. Geneva: International Standard Organization. 2002.
9. Utzschneider S, Harrasser N, Schroeder C, Mazoochian F, Jansson V. Wear of contemporary total knee replacements: a knee simulator study of six current designs. Clin Biomech. 2009;24(7):583-8. doi:10.1016/j.clinbiomech.2009.04.007.
10. Niedzwiecki S, Klapperich C, Short J, Jani S, Ries M, Pruitt L. Comparison of three joint simulator wear debris isolation techniques: acid digestion, base digestion, and enzyme cleavage. J Biomed Mater Res. 2001;56(2):245-9. (Pubitemid 32520700)
11. 17853. IASI. Wear of implant particles-polymer and metal wear particles - isolation, characterization and quantification. Geneva: International Organization for Standardization. 2008.
12. Utzschneider S, Paulus A, Datz JC, Schroeder C, Sievers B, Wegener B, et al. Influence of design and bearing material on polyethylene wear particle generation in total knee replacement. Acta Biomater. 2009;5(7):2495-502. doi:10.1016/j.actbio.2009.03.016.
13. Paulus A, Schröder C, Sievers B, Frenzel J, Jansson V, Utzschneider S. Evaluation of different methods to eliminate adherent endotoxin of polyethylene wear particles. Wear. 2012;295:319-25.
14. Vermes C, Chandrasekaran R, Jacobs JJ, Galante JO, Roebuck KA, Glant TT. The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am Vol. 2001;83(A(2)):201-11.
15. Yao J, Cs-Szabo G, Jacobs JJ, Kuettner KE, Glant TT. Suppression of osteoblast function by titanium particles. J Bone Joint Surg Am Vol. 1997;79(1):107-12. (Pubitemid 27057457)
16. Catelas I, Petit A, Marchand R, Zukor DJ, Yahia L, Huk OL. Cytotoxicity and macrophage cytokine release induced by ceramic and polyethylene particles in vitro. J Bone Joint Surg Am Vol. 1999;81(3):516-21. (Pubitemid 29245912)
17. Green TR, Fisher J, Stone M, Wroblewski BM, Ingham E. Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro. Biomaterials. 1998;19(24):2297-302. (Pubitemid 28550396)
18. Matthews JB, Green TR, Stone MH, Wroblewski BM, Fisher J, Ingham E. Comparison of the response of primary murine peritoneal macrophages and the U937 human histiocytic cell line to challenge with in vitro generated clinically relevant UHMWPE particles. Bio-Med Mater Eng. 2000;10(3-4):229-40.
19. Utzschneider S, Becker F, Grupp TM, Sievers B, Paulus A, Gottschalk O, et al. Inflammatory response against different carbon fiber-reinforced PEEK wear particles compared with UHMWPE in vivo. Acta Biomater. 2010;6(11):4296-304. doi:10.1016/j.actbio.2010.06.002.
20. Zysk SP, Gebhard H, Plitz W, Buchhorn GH, Sprecher CM, Jansson V, et al. Influence of orthopedic particulate biomaterials on inflammation and synovial microcirculation in the murine knee joint. J Biomed Mater Res B Appl Biomater. 2004;71(1):108-15. doi:10.1002/jbm.b.30075. (Pubitemid 39299410)
21. Zysk SP, Gebhard HH, Kalteis T, Schmitt-Sody M, Jansson V, Messmer K, et al. Particles of all sizes provoke inflammatory responses in vivo. Clin Orthop Relat Res. 2005;433:258-64. (Pubitemid 40489278)
22. Zeintl H, Sack FU, Intaglietta M, Messmer K. Computer assisted leukocyte adhesion measurement in intravital microscopy. Int J Microcirc Clin Exp. 1989;8(3):293-302.
23. Wooley PH, Morren R, Andary J, Sud S, Yang SY, Mayton L, et al. Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials. 2002;23(2):517-26. (Pubitemid 33051040)
24. Brackertz D, Mitchell GF, Mackay IR. Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum. 1977;20(3):841-850.
25. Lorber V, Paulus AC, Buschmann A, Schmitt B, Grupp TM, Jansson V, et al. Elevated cytokine expression of different PEEK wear particles compared to UHMWPE in vivo. J Mater Sci Mater Med. 2014;25(1):141-9. doi:10.1007/s10856-013-5037- 8.
26. Schmalzried TP, Jasty M, Harris WH. Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and the concept of the effective joint space. J Bone Joint Surg Am Vol. 1992;74(6):849-63.
27. Urban RM, Jacobs JJ, Tomlinson MJ, Gavrilovic J, Black J, Peoc'h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J Bone Joint Surg Am Vol. 2000;82(4):457-76.
28. Gallo J, Slouf M, Goodman SB. The relationship of polyethylene wear to particle size, distribution, and number: a possible factor explaining the risk of osteolysis after hip arthroplasty. J Biomed Mater Res B Appl Biomater. 2010;94(1):171-7. doi:10.1002/jbm.b.31638.
29. Greenfield EM, Bi Y, Ragab AA, Goldberg VM, Nalepka JL, Seabold JM. Does endotoxin contribute to aseptic loosening of orthopedic implants? J Biomed Mater Res B Appl Biomater. 2005;72(1):179-85. doi:10.1002/jbm.b.30150. (Pubitemid 40039625)
30. Revell PA. The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses. J R Soc Interface. 2008;5(28):1263-78. doi:10.1098/rsif 2008.0142.
31. Catelas I, Huk OL, Petit A, Zukor DJ, Marchand R, Yahia L. Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: effects of size, concentration, and composition. J Biomed Mater Res. 1998;41(4):600-7. (Pubitemid 28355445)
32. Endo M, Tipper JL, Barton DC, Stone MH, Ingham E, Fisher J. Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses. Proc Inst Mech Eng [H]. 2002;216(2):111-22. (Pubitemid 34410659)
33. Fisher J, Bell J, Barbour PS, Tipper JL, Matthews JB, Besong AA, et al. A novel method for the prediction of functional biological activity of polyethylene wear debris. Proc Inst Mech Eng [H]. 2001;215(2):127-32. (Pubitemid 34448613)
34. Green TR, Fisher J, Matthews JB, Stone MH, Ingham E. Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles. J Biomed Mater Res. 2000;53(5):490-7.
35. Illgen RL 2nd, Forsythe TM, Pike JW, Laurent MP, Blanchard CR. Highly crosslinked vs conventional polyethylene particles-an in vitro comparison of biologic activities. J Arthroplast. 2008;23(5):721-31. doi:10.1016/j.arth.2007. 05.043.
36. Ingham E, Fisher J. Biological reactions to wear debris in total joint replacement. Proc Inst Mech Eng [H]. 2000;214(1):21-37. (Pubitemid 32508299)
37. Ingram JH, Kowalski R, Fisher J, Ingham E. The osteolytic response of macrophages to challenge with particles of Simplex P, Endurance, Palacos R, and Vertebroplastic bone cement particles in vitro. J Biomed Mater Res B Appl Biomater. 2005;75(1):210-20. doi:10.1002/jbm.b.30308. (Pubitemid 41395763)
38. Kraft CN, Schlegel U, Pfluger D, Eijer H, Textor J, Hansis M, et al. Radiological signs of osteitis around extramedullary metal implants. A radiographic-microbiological correlative analysis in rabbit tibiae after local inoculation of Staphylococcus aureus. Arch Orthop Trauma Surg. 2001;121(6):338-42. (Pubitemid 32591037)
39. Kraft CN, Diedrich O, Burian B, Schmitt O, Wimmer MA. Microvascular response of striated muscle to metal debris. A comparative in vivo study with titanium and stainless steel. J Bone Joint Surg Br. 2003;85(1):133-41.
40. Howie DW, Vernon-Roberts B. The synovial response to intra-articular cobalt-chrome wear particles. Clin Orthop Relat Res. 1988;232:244-54.
41. Howie DW, Manthey B, Hay S, Vernon-Roberts B. The synovial response to intraarticular injection in rats of polyethylene wear particles. Clin Orthop Relat Res. 1993;292:352-7. (Pubitemid 23206291)
42. Oral E, Muratoglu OK. Vitamin E diffused, highly crosslinked UHMWPE: a review. Int Orthop. 2011;35(2):215-23. doi:10.1007/s00264-010-1161-y.
43. Illgen RL 2nd, Bauer LM, Hotujec BT, Kolpin SE, Bakhtiar A, Forsythe TM. Highly crosslinked vs conventional polyethylene particles: relative in vivo inflammatory response. J Arthroplast. 2009;24(1):117-24. doi:10.1016/j.arth. 2008.01.134.
44. Kurtz SM, Costa L. UHMWPE for arthroplasty: from powder to debris. Editorial comment: a perspective on polyethylene. Clin Orthop Relat Res. 2011;469(8):2260-1. doi:10.1007/s11999-011-1853-7.
45. Inacio MC, Cafri G, Paxton EW, Kurtz SM, Namba RS. Alternative bearings in total knee arthroplasty: risk of early revision compared to traditional bearings: an analysis of 62,177 primary cases. Acta Orthop. 2013;84(2):145-52. doi:10.3109/17453674.2013.784660.
46. Hodrick JT, Severson EP, McAlister DS, Dahl B, Hofmann AA. Highly crosslinked polyethylene is safe for use in total knee arthroplasty. Clin Orthop Relat Res. 2008;466(11):2806-12. doi:10.1007/s11999-008-0472-4.
47. Minoda Y, Aihara M, Sakawa A, Fukuoka S, Hayakawa K, Tomita M, et al. Comparison between highly cross-linked and conventional polyethylene in total knee arthroplasty. Knee. 2009;16(5):348-51. doi:10.1016/j.knee.2009.01.005.
48. Libouban H, Massin P, Gaudin C, Mercier P, Basle MF, Chappard D. Migration of wear debris of polyethylene depends on bone microarchitecture. J Biomed Mater Res B Appl Biomater. 2009;90(2):730-7. doi:10.1002/jbm.b.31341.
49. Otto M. Classification of prosthetic loosening and determination of wear particles. Der Pathol. 2008;29(Suppl 2):232-9. doi:10.1007/s00292-008-1070-7.
50. Massin P, Chappard D, Flautre B, Hardouin P. Migration of polyethylene particles around nonloosened cemented femoral components from a total hip arthroplasty-an autopsy study. J Biomed Mater Res B Appl Biomater. 2004;69(2):205-15. doi:10.1002/jbm.b.30001. (Pubitemid 38619778)
51. Burian B, Wimmer MA, Kunze J, Sprecher CM, Pennekamp PH, von Engelhardt LV, et al. Systemic spread of wear debris: an in vivo study. Z Orthop Ihre Grenzgeb. 2006;144(5):539-44. doi:10.1055/s-2006-942168. (Pubitemid 44681888)
52. Park DY, Min BH, Kim DW, Song BR, Kim M, Kim YJ. Polyethylene wear particles play a role in development of osteoarthritis via detrimental effects on cartilage, meniscus, and synovium. OARS. 2013;21(12):2021-9. doi:10.1016/j.joca.2013.09.013.
53. Catelas I, Wimmer MA, Utzschneider S. Polyethylene and metal wear particles: characteristics and biological effects. Semin Immunopathol. 2011;33(3):257-71. doi:10.1007/s00281-011-0242-3.