The gene-immune-behavioral pathway: Gamma-interferon (IFN-γ) simultaneously coordinates susceptibility to infectious disease and harm avoidance behaviors

Brain, Behavior, and Immunity

Volumn 35, Issue , 2014, Pages 169-175

  MacMurray, James ^a   Comings, David E ^b   Napolioni, Valerio ^c  

^a Carlsbad Science Foundation   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c Genetics and Biology   (Italy)

Author keywords

Behavior; Brain; Gamma interferon; Genetics; Harm Avoidance; Immunity; Infectious disease; Personality trait; Polymorphism; Serotonin

Indexed keywords

GAMMA INTERFERON; MESSENGER RNA; IFNG PROTEIN, HUMAN;

ADULT; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR; CHAGAS DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EXPLORATORY BEHAVIOR; EXPLORATORY EXCITABILITY BEHAVIOR; EXTRAVERSION; FEMALE; GAMMA INTERFERON GENE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HARM AVOIDANCE BEHAVIOR; HIGH RISK POPULATION; HUMAN; INFECTION; INFECTION RISK; LEPROSY; MALARIA; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; OPENNESS TO EXPERIENCE BEHAVIOR; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TUBERCULOSIS; YOUNG ADULT; CHARACTER; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; PERSONALITY; PERSONALITY TEST; PHYSIOLOGY; PSYCHOLOGY; TEMPERAMENT;

ADULT; AVOIDANCE LEARNING; CHARACTER; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFECTION; INTERFERON-GAMMA; MALE; MIDDLE AGED; PERSONALITY; PERSONALITY INVENTORY; POLYMORPHISM, SINGLE NUCLEOTIDE; TEMPERAMENT; YOUNG ADULT;

EID: 84903710003     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2013.09.012     Document Type: Article

References (49)

1. Ando, J., Ono, Y., Yoshimura, K., Onoda, N., Shinohara, M., Kanba, S., et al., 2002. The genetic structure of Cloninger's seven-factor model of temperament and character in a Japanese sample. J. Pers. 70, 583-609.
2. Arranz, L., Guayerbas, N., De la Fuente, M., 2007. Impairment of several immune functions in anxious women. J. Psychosom. Res. 62, 1-8.
3. Brüne, M., 2006. The evolutionary psychology of obsessive-compulsive disorder: the role of cognitive metarepresentation. Perspect. Biol. Med. 49, 317-329.
4. Cardoso, C.C., Pereira, A.C., Brito-de-Souza, V.N., Dias-Baptista, I.M., Maniero, V.C., Venturini, J., et al., 2010. IFNG +874 T > A single nucleotide polymorphism is associated with leprosy among Brazilians. Hum. Genet. 128, 481-490.
5. Chevillard, C., Moukoko, C.E., Elwali, N.E., Bream, J.H., Kouriba, B., Argiro, L., et al., 2003. IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni). J. Immunol. 171, 5596-5601.
6. Cloninger, C.R., 1987. A systematic method for clinical description and classification of personality variants. Arch. Gen. Psychiatry 44, 573-588.
7. Cloninger, C.R., Svrakic, D.M., Przybeck, T.R., 1993. A psychobiological model of temperament and character. Arch. Gen. Psychiatry 50, 975-990.
8. Cloninger, C.R., 1999. The Temperament and Character Inventory-Revised, Center for Psychobiology of Personality. Washington University, St. Louis, MO.
9. Costa, P.T., McCrae, R.R., 1992. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual. Psychological Assessment Resources, Odessa, FL.
10. Daher, S., Shulzhenko, N., Morgun, A., Mattar, R., Rampim, G.F., Camano, L., et al., 2003. Associations between cytokine gene polymorphisms and recurrent pregnancy loss. J. Reprod. Immunol. 58, 69-77.
11. de Albuquerque, A.C., Rocha, L.Q., de Morais Batista, A.H., Teixeira, A.B., Dos Santos, D.B., Nogueira, N.A., 2012. Association of polymorphism +874 A/T of interferon γ and susceptibility to the development of tuberculosis: meta-analysis. Eur. J. Clin. Microbiol. Infect. Dis. 31, 2887-2895.
12. Dickerson, S.S., Gable, S.L., Irwin, M.R., Aziz, N., Kemeny, M.E., 2009. Socialevaluative threat and proinflammatory cytokine regulation: an experimental laboratory investigation. Psychol. Sci. 20, 1237-1244.
13. Elena, S.F., Sanjuán, R., 2003. Climb every mountain? Science 5653, 2074-2075.
14. Enoch, M.A., White, K.V., Waheed, J., Goldman, D., 2008. Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders. Depress Anxiety 25, 383-392.
15. Feygin, D.L., Swain, J.E., Leckman, J.F., 2006. The normalcy of neurosis: evolutionary origins of obsessive-compulsive disorder and related behaviors. Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 854-864.
16. Fincher, C.L., Thornhill, R., Murray, D.R., Schaller, M., 2008. Pathogen prevalence predicts human cross-cultural variability in individualism/collectivism. Proc. Biol. Sci. 275, 1279-1285.
17. Hansenne, M., Ansseau, M., 1999. Harm avoidance and serotonin. Biol. Psychol. 51, 77-81.
18. Jeanmonod, P., von Känel, R., Maly, F.E., Fischer, J.E., 2004. Elevated Plasma Creactive protein in chronically distressed subjects who carry the A allele of the TNF-alpha -308 G/A polymorphism. Psychosom. Med. 66, 501-506.
19. Koller, G., Zill, P., Skoruppa, T., Bondy, B., Preuss, U.W., Soyka, M., 2008. Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals. Psychiatr. Genet. 18, 59-63.
20. Leentjens, A.F., Scholtissen, B., Vreeling, F.W., Verhey, F.R., 2006. The serotonergic hypothesis for depression in Parkinson's disease: an experimental approach. Neuropsychopharmacology 31, 1009-1015.
21. Maes, M., Berk, M., Goehler, L., Song, C., Anderson, G., Galecki, P., et al., 2012. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med. 10, 66.
22. Manry, J., Laval, G., Patin, E., Fornarino, S., Tichit, M., Bouchier, C., Barreiro, L.B., Quintana-Murci, L., 2011. Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity. Hum. Mutat. 32, 633-642.
23. Matos, G.I., Covas Cde, J., Bittar Rde, C., Gomes-Silva, A., Marques, F., Maniero, V.C., et al., 2007. IFNG +874T/A polymorphism is not associated with American tegumentary leishmaniasis susceptibility but can influence Leishmania induced IFN-gamma production. BMC Infect. Dis. 7, 33.
24. McVean, G.A., Abecasis, D.M., Auton, R.M., Brooks, G.A.R., Depristo, D.R., Durbin, A., et al., 2012. An integrated map of genetic variation from 1, 092 human genomes. Nature 491, 56-65.
25. Medina, T.S., Costa, S.P., Oliveira, M.D., Ventura, A.M., Souza, J.M., Gomes, T.F., et al., 2011. Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism. Malar. J. 10, 264.
26. Minor, T.R., Hunter, A.M., 2002. Stressor controllability and learned helplessness research in the United States: sensitization and fatigue processes. Integr. Physiol. Behav. Sci. 37, 44-58.
27. Mommersteeg, P.M., Pelle, A.J., Ramakers, C., Szabó, B.M., Denollet, J., Kupper, N., 2012. Type D personality and course of health status over 18 months in outpatients with heart failure: multiple mediating inflammatory biomarkers. Brain Behav. Immun. 26, 301-310.
28. Mortensen, C.R., Becker, D.V., Ackerman, J.M., Neuberg, S.L., Kenrick, D.T., 2010. Infection breeds reticence: the effects of disease salience on self-perceptions of personality and behavioral avoidance tendencies. Psychol. Sci. 21, 440-447.
29. Myint, A.M., Bondy, B., Baghai, T.C., Eser, D., Nothdurfter, C., Schüle, C., et al., 2013. Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene. Brain Behav. Immun. 31, 128-133.
30. Oxenkrug, G.F., 2011. Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. J. Neural. Transm. 118, 75-85.
31. Pasha, H.F., Radwan, M.I., Hagrass, H.A., Tantawy, E.A., Emara, M.H., 2013. Cytokines genes polymorphisms in chronic hepatitis C: impact on susceptibility to infection and response to therapy. Cytokine 61, 478-484.
32. Peresi, E., Oliveira, L.R., da Silva, W.L., da Costa, E.A., Araujo Jr., J.P., Ayres, J.A., et al., 2013. Cytokine polymorphisms, their influence and levels in Brazilian patients with pulmonary tuberculosis during antituberculosis treatment. Tuberculosis Res. Treat. 2013, 285094.
33. Perugi, G., Canonico, P.L., Carbonato, P., Mencacci, C., Muscettola, G., Pani, L., et al., 2011. Unexplained somatic symptoms during major depression: prevalence and clinical impact in a national sample of Italian psychiatric outpatients. Psychopathology 44, 116-124.
34. Pernerger, T.V., 1998. What's wrong with Bonferroni adjustments? BMJ 316, 1236-1238.
35. Pravica, V., Perrey, C., Stevens, A., Lee, J.H., Hutchinson, I.V., 2000. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFNgamma production. Hum. Immunol. 61, 863-866.
36. Prigoshin, N., Tambutti, M., Larriba, J., Gogorza, S., Testa, R., 2004. Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause. Am. J. Reprod. Immunol. 52, 36-41.
37. Raitala, A., Pertovaara, M., Karjalainen, J., Oja, S.S., Hurme, M., 2005. Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals. Scand. J. Immunol. 61, 387-390.
38. Rasouli, M., Kiany, S., 2007. Association of interferon-gamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis in Iranian patients. Cytokine 38, 49-53.
39. Rothman, K.J., 1990. No adjustments are needed for multiple comparisons. Epidemiology 1, 43-46.
40. Schaller, M., Murray, D.R., 2008. Pathogens, personality, and culture: disease prevalence predicts worldwide variability in sociosexuality, extraversion, and openness to experience. J. Pers. Soc. Psychol. 95, 212-221.
41. Schaller, M., 2011. The behavioural immune system and the psychology of human sociality. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 3418-3426.
42. Sherry, S.T., Ward, M.H., Kholodov, M., Baker, J., Phan, L., Smigielski, E.M., et al., 2001. DbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 29, 308-311.
43. Shrira, I., Wisman, A., Webster, G., 2013. Guns, germs, and stealing: exploring the link between infectious disease and crime. Evol. Psychol. 11, 270-287.
44. Stallings, M.C., Hewitt, J.K., Cloninger, C.R., Heath, A.C., Eaves, L.J., 1996. Genetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperament dimensions? J. Pers. Soc. Psychol. 70, 127-140.
45. Titmarsh, C.J., Moscovis, S.M., Hall, S., Tzanakaki, G., Kesanopoulos, K., Xirogianni, A., Scott, R.J., Blackwell, C.C., 2013. Comparison of cytokine gene polymorphisms among Greek patients with invasive meningococcal disease or viral meningitis. J. Med. Microbiol. 62, 694-700.
46. Torres, O.A., Calzada, J.E., Beraún, Y., Morillo, C.A., González, A., González, C.I., et al., 2010. Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population. Infect. Genet. Evol. 10, 682-685.
47. van Heesch, F., Prins, J., Korte-Bouws, G.A., Westphal, K.G., Lemstra, S., Olivier, B., et al., 2013. Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice. Behav. Brain Res. 253C, 191-195.
48. Weschenfelder, J., Sander, C., Kluge, M., Kirkby, K.C., Himmerich, H., 2012. The influence of cytokines on wakefulness regulation: clinical relevance, mechanisms and methodological problems. Psychiatr. Danub. 24, 112-126.
49. Wu, I.T., Lee, I.H., Yeh, T.L., Chen, K.C., Chen, P.S., Yao, W.J., et al., 2010. The association between the harm avoidance subscale of the Tridimensional Personality Questionnaire and serotonin transporter availability in the brainstem of male volunteers. Psychiatry Res. 181, 241-244.