Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes

Food and Chemical Toxicology

Volumn 71, Issue , 2014, Pages 90-96

  Shen, Guolin ^a   Zhuang, Xiaomei ^a,b   Xiao, Weibin ^a,b   Kong, Linglei ^a,b   Tan, Yan ^a   Li, Hua ^a,b  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b State Key Laboratory of Toxicology and Medical Countermeasures   (China)

Author keywords

CYP3A; Hepatotoxicity; Liver microsomes; Metabolism; Sandwich cultured hepatocytes; Triptolide

Indexed keywords

CYTOCHROME P450 3A; DEXAMETHASONE; KETOCONAZOLE; MIDAZOLAM; PLACEBO; TRIPTOLIDE; CYTOCHROME P450 3A INHIBITOR; DITERPENE; EPOXIDE; PHENANTHRENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DETOXIFICATION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; IC 50; LIVER CELL CULTURE; LIVER CLEARANCE; LIVER INJURY; LIVER MICROSOME; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; RISK REDUCTION; TOXICOKINETICS; CELL CULTURE; DRUG MECHANISM; ENZYME KINETICS; IC50; IN VITRO STUDY; LIVER CELL; PROTEIN FUNCTION; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; LIVER; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS; TRIPTERYGIUM WILFORDII;

ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 CYP3A INHIBITORS; DITERPENES; EPOXY COMPOUNDS; HEPATOCYTES; LIVER; MALE; MICROSOMES, LIVER; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84903692380     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.05.020     Document Type: Article

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