Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation

International Journal of Radiation Biology

Volumn 90, Issue 7, 2014, Pages 560-574

  Rombouts, Charlotte ^a,b   Aerts, An ^a   Quintens, Roel ^a   Baselet, Bjorn ^a,e   El Saghire, Hussein ^a   Harms Ringdahl, Mats ^c   Haghdoost, Siamak ^c   Janssen, Ann ^a   Michaux, Arlette ^a   Yentrapalli, Ramesh ^c,d   Benotmane, Mohammed Abderrafi ^a   Van Oostveldt, Patrick ^b   Baatout, Sarah ^a,b  

^a BELGIAN NUCLEAR RESEARCH CENTRE   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

Chronic low dose rate ionizing radiation; Endothelial cells; Gene expression; Senescence

Indexed keywords

IGFBP5 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; RNA; SMAD PROTEIN; SOMATOMEDIN BINDING PROTEIN 5; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENDOTHELIUM CELL; GAMMA IRRADIATION; GAMMA RADIATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; PREMATURE SENESCENCE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTOMICS; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

CHRONIC LOW DOSE RATE IONIZING RADIATION; ENDOTHELIAL CELLS; GENE EXPRESSION; SENESCENCE;

CELL AGING; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION PROFILING; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTOME;

EID: 84903688632     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2014.905724     Document Type: Article

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