Endothelial cell EphrinB2-dependent activation of monocytes in arteriosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 2, 2011, Pages 297-305

  Braun, Jennifer ^a   Hoffmann, Sabrina C ^a   Feldner, Anja ^a   Ludwig, Thomas ^b   Henning, Rob ^c   Hecker, Markus ^a   Korff, Thomas ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

arteriosclerosis; endothelium; immune system; leukocytes

Indexed keywords

EPHRIN B2; EPHRIN B3; EPHRIN RECEPTOR B2; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTERIOSCLEROSIS; ARTICLE; CELL ACTIVATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEUKEMIA CELL LINE; MACROPHAGE; MICROCIRCULATION; MONOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; VASCULARIZATION;

ANIMALS; ARTERIOSCLEROSIS; BIOLOGICAL MARKERS; CELL ADHESION; CELLS, CULTURED; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; EPHRIN-B2; HUMANS; INTERLEUKIN-8; MICE; MICE, INBRED STRAINS; MICROCIRCULATION; MONOCYTES; UP-REGULATION;

EID: 79551505065     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.217646     Document Type: Article

References (44)

1. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 2002;3:475-486.
2. Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998;93:741-753.
3. Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999;4:403-414.
4. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999; 13:295-306.
5. Augustin HG, Reiss Y. EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis. Cell Tissue Res. 2003;314:25-31.
6. Kuijper S, Turner CJ, Adams RH. Regulation of angiogenesis by Eph-ephrin interactions. Trends Cardiovasc Med. 2007;17:145-151.
7. Zhang J, Hughes S. Role of the ephrin and Eph receptor tyrosine kinase families in angiogenesis and development of the cardiovascular system. J Pathol. 2006;208:453-461.
8. Luo H, Yu G, Tremblay J, Wu J. EphB6-null mutation results in compromised T cell function. J Clin Invest. 2004;114:1762-1773.
9. Luo H, Yu G, Wu Y, Wu J. EphB6 crosslinking results in costimulation of T cells. J Clin Invest. 2002;110:1141-1150.
10. Yu G, Luo H, Wu Y, Wu J. EphrinB2 induces T cell costimulation. J Immunol. 2003;171:106-114.
11. Korff T, Braun J, Pfaff D, Augustin HG, Hecker M. Role of ephrinB2 expression in endothelial cells during arteriogenesis: impact on smooth muscle cell migration and monocyte recruitment. Blood. 2008;112:73-81.
12. Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R, Ludwig T, Korff T, Hecker M, Augustin HG. Involvment of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. J Cell Sci. 2008;121:3842-3850.
13. Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, Schaffner F, Augustin HG. Endothelial ephrinB2 is controlled by micro-environmental determinants and associates context-dependently with CD31. Arterioscler Thromb Vasc Biol. 2006;26:468-474.
14. Goettsch W, Augustin HG, Morawietz H. Down-regulation of endothelial ephrinB2 expression by laminar shear stress. Endothelium. 2004;11: 259-265.
15. Ross R. Atherosclerosis an inflammatory disease. N Engl J Med. 1999; 340:115-126.
16. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(23 Suppl 1):III27-III32.
17. Libby P, Aikawa M, Jain MK. Vascular endothelium and atherosclerosis. Handb Exp Pharmacol. 2006;(176 Pt 2):285-306.
18. Katsu M, Koyama H, Maekawa H, Kurihara H, Uchida H, Hamada H. Ex vivo gene delivery of ephrinB2 induces development of functional collateral vessels in a rabbit model of hind limb ischemia. J Vasc Surg. 2009;49:192-198.
19. Holness CL, Simmons DL. Molecular Cloning of CD68, a human mac-rophage marker related to lysosomal glycoproteins. Blood. 1993;81: 1607-1613.
20. Füller T, Korff T, Kilian A, Dandekar G, Augustin HG. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci. 2003;116:2461-2470.
21. Himanen JP, Nikolov DB. Eph signaling: a structural view. Trend Neurosci. 2003;26:46-51.
22. Adams RH. Molecular control of arterial-venous blood vessel identity. J Anat. 2003;202:105-112.
23. Vihanto MM, Plock J, Erni D, Frey BM, Frey FJ, Huynh-Do U. Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin. FASEB J. 2005;19:1689-1691.
24. Schaper W, Scholz D. Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol. 2003;23:1143-1151.
25. Van der Laan PA, Reardon CA, Getz CS. Site specifity of atherosclerosis: site-selective responses to atherosclerotic modulators. Arterioscler Thromb Vasc Biol. 2004;24:12-22.
26. Frangos SG, Gahtan V, Sumpio B. Localization of atherosclerosis: role of hemodynamics. Arch Surg. 1999;134:1142-1149.
27. Perktold K, Rappitsch G. Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model. J Biomech. 1995;28:845-856.
28. Karino T, Goldsmith HL, Motomiya M, Mabuchi S, Sohara Y. Flow patterns in vessels of simple and complex geometries. Ann N Y Acad Sci. 1987;516:422-441.
29. Chappell DC, Varner SE Nerem RM, Medford RM, Alexander RW. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res. 1998;82:532-539.
30. Newby AC. An Overview of the vascular response to injury: a tribute to the late Russel Ross. Toxicol Lett. 2000;112-113:519-529.
31. Meerschaert J, Furie MB. The adhesion molecules used by monocytes for migration across endothelium include CD11a/CD18, CD11b/CD18, and VLA-4 on monocytes and ICAM-1, VCAM-1, and other ligands on endothelium. J Immunol. 1995;154:4099-4112.
32. Schenkel AR, Mamdouh Z, Muller WA. Locomotion of monocytes on endothelium is a critical step during extravasation. Nat Immunol. 2004; 5:393-400.
33. Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, Luis de la Pompa J, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW. Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol. 1999;162:3022-3030.
34. Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med. 1993;178: 449-460.
35. Lukacs NW, Strieter RM, Elner VM, Evanoff HL, Burdick M, Kunkel SL. Intercellular adhesion molecule-1 mediates the expression of monocyte-derived MIP-1a during monocyte-endothelial cell interactions. Blood. 1994;83:1174-1178.
36. Wagner AH, Güldenzoph B, Lienenluke B, Hecker M. CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction. Arterioscler Thromb Vasc Biol. 2004;24:715-720.
37. Reape TJ, Groot PH. Chemokines and atherosclerosis. Atherosclerosis. 1999;147:213-225.
38. Apostolopoulus J, Davenport P, Tipping PG. Interleukin-8 production by macrophages from atheromatous plaques. Arterioscler Thromb Vasc Biol. 1996;16:1007-1012.
39. Wang N, Tabas I, Winchester R, Ravalli S, Rabbani LE, Tall A. Interleukin-8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J Biol Chem. 1996;271:8837-8842.
40. Ribeiro R.A. Flores C.A. Cunha FQ, Ferreira S.H. IL-8 causes in vivo neutrophil migration by a cell-dependent mechanism. Immunology. 1991; 73:472-477.
41. Boisvert WA, Santiago R, Curtiss LK, Terkeltaub RA. A leukocte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL-receptor-deficient mice. J Clin Invest. 1998;101:353-363.
42. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Luscinskas FW, Rosenzweig A. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999;398:718-723.
43. Libby P, Geng YJ, Aikawa M, Schoenbeck U, Mach F, Clinton SK, Sukhova GK, Lee RT. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol. 1996;7:330-335.
44. Lessner SM, Prado HL, Waller EK, Galis ZS. Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model. Am J Pathol. 2002;160:2145-2155.