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Volumn 30, Issue 11, 2010, Pages 2608-2620

The ras effector RASSF2 controls the PAR-4 tumor suppressor

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; NUCLEAR PROTEIN; PROSTATE APOPTOSIS RESPONSE PROTEIN 4; RASSF2 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 77952589038     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00208-09     Document Type: Article
Times cited : (28)

References (49)
  • 2
    • 0035022291 scopus 로고    scopus 로고
    • Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia
    • Boehrer, S., K. U. Chow, E. Puccetti, M. Ruthardt, S. Godzisard, A. Krapohl, B. Schneider, D. Hoelzer, P. S. Mitrou, V. M. Rangnekar, and E. Weidmann. 2001. Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia. Hematol. J. 2:103-107.
    • (2001) Hematol. J. , vol.2 , pp. 103-107
    • Boehrer, S.1    Chow, K.U.2    Puccetti, E.3    Ruthardt, M.4    Godzisard, S.5    Krapohl, A.6    Schneider, B.7    Hoelzer, D.8    Mitrou, P.S.9    Rangnekar, V.M.10    Weidmann, E.11
  • 5
    • 0035477544 scopus 로고    scopus 로고
    • Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression
    • Chakraborty, M., S. G. Qiu, K. M. Vasudevan, and V. M. Rangnekar. 2001. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res. 61:7255-7263.
    • (2001) Cancer Res. , vol.61 , pp. 7255-7263
    • Chakraborty, M.1    Qiu, S.G.2    Vasudevan, K.M.3    Rangnekar, V.M.4
  • 10
    • 1642553461 scopus 로고    scopus 로고
    • The dark side of Ras: Regulation of apoptosis
    • Cox, A. D., and C. J. Der. 2003. The dark side of Ras: regulation of apoptosis. Oncogene 22:8999-9006.
    • (2003) Oncogene , vol.22 , pp. 8999-9006
    • Cox, A.D.1    Der, C.J.2
  • 11
    • 0030572696 scopus 로고    scopus 로고
    • The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    • Diaz-Meco, M. T., M. M. Municio, S. Frutos, P. Sanchez, J. Lozano, L. Sanz, and J. Moscat. 1996. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 86:777-786.
    • (1996) Cell , vol.86 , pp. 777-786
    • Diaz-Meco, M.T.1    Municio, M.M.2    Frutos, S.3    Sanchez, P.4    Lozano, J.5    Sanz, L.6    Moscat, J.7
  • 12
    • 35548987430 scopus 로고    scopus 로고
    • The RASSF1A tumor suppressor
    • Donninger, H., M. D. Vos, and G. J. Clark. 2007. The RASSF1A tumor suppressor. J. Cell Sci. 120:3163-3172.
    • (2007) J. Cell Sci. , vol.120 , pp. 3163-3172
    • Donninger, H.1    Vos, M.D.2    Clark, G.J.3
  • 13
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward, J. 2003. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3:11-22.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 15
    • 0043133881 scopus 로고    scopus 로고
    • Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells
    • El-Guendy, N., Y. Zhao, S. Gurumurthy, R. Burikhanov, and V. M. Rangnekar. 2003. Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells. Mol. Cell. Biol. 23:5516-5525.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5516-5525
    • El-Guendy, N.1    Zhao, Y.2    Gurumurthy, S.3    Burikhanov, R.4    Rangnekar, V.M.5
  • 16
    • 28644450906 scopus 로고    scopus 로고
    • RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
    • DOI 10.1038/sj.bjc.6602854
    • Endoh, M., G. Tamura, T. Honda, N. Homma, M. Terashima, S. Nishizuka, and T. Motoyama. 2005. RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer. Br. J. Cancer 93:1395-1399. (Pubitemid 41752867)
    • (2005) British Journal of Cancer , vol.93 , Issue.12 , pp. 1395-1399
    • Endoh, M.1    Tamura, G.2    Honda, T.3    Homma, N.4    Terashima, M.5    Nishizuka, S.6    Motoyama, T.7
  • 18
    • 0035067298 scopus 로고    scopus 로고
    • Mammalian expression vectors for Ras family proteins: Generation and use of expression constructs to analyze Ras family function
    • Fiordalisi, J. J., R. L. Johnson II, A. S. Ulku, C. J. Der, and A. D. Cox. 2001. Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function. Methods Enzymol. 332:3-36.
    • (2001) Methods Enzymol. , vol.332 , pp. 3-36
    • Fiordalisi, J.J.1    Johnson II, R.L.2    Ulku, A.S.3    Der, C.J.4    Cox, A.D.5
  • 20
    • 0242585506 scopus 로고    scopus 로고
    • Genetic inactivation of Par4 results in hyperactivation of NF-κB and impairment of JNK and p38
    • DOI 10.1038/sj.embor.embor769
    • Garcia-Cao, I., M. J. Lafuente, L. M. Criado, M. T. Diaz-Meco, M. Serrano, and J. Moscat. 2003. Genetic inactivation of Par4 results in hyperactivation of NF-κB and impairment of JNK and p38. EMBO Rep. 4:307-312. (Pubitemid 36511729)
    • (2003) EMBO Reports , vol.4 , Issue.3 , pp. 307-312
    • Garcia-Cao, I.1    Lafuente, M.J.2    Criado, L.M.3    Diaz-Meco, M.T.4    Serrano, M.5    Moscat, J.6
  • 22
    • 34047250808 scopus 로고    scopus 로고
    • RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network
    • Guo, C., S. Tommasi, L. Liu, J. K. Yee, R. Dammann, and G. P. Pfeifer. 2007. RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr. Biol. 17:700-705.
    • (2007) Curr. Biol. , vol.17 , pp. 700-705
    • Guo, C.1    Tommasi, S.2    Liu, L.3    Yee, J.K.4    Dammann, R.5    Pfeifer, G.P.6
  • 23
    • 12844253808 scopus 로고    scopus 로고
    • Phosphorylation of Par-4 by protein kinase a is critical for apoptosis
    • Gurumurthy, S., A. Goswami, K. M. Vasudevan, and V. M. Rangnekar. 2005. Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol. Cell. Biol. 25:1146-1161.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1146-1161
    • Gurumurthy, S.1    Goswami, A.2    Vasudevan, K.M.3    Rangnekar, V.M.4
  • 24
    • 20544445183 scopus 로고    scopus 로고
    • CpG island promoter hypermethylation of a novel Raseffector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations
    • Hesson, L. B., R. Wilson, D. Morton, C. Adams, M. Walker, E. R. Maher, and F. Latif. 2005. CpG island promoter hypermethylation of a novel Raseffector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. Oncogene 24:3987-3994.
    • (2005) Oncogene , vol.24 , pp. 3987-3994
    • Hesson, L.B.1    Wilson, R.2    Morton, D.3    Adams, C.4    Walker, M.5    Maher, E.R.6    Latif, F.7
  • 29
    • 33947099350 scopus 로고    scopus 로고
    • Nuclear transport of Ras-associated tumor suppressor proteins: Different transport receptor binding specificities for arginine-rich nuclear targeting signals
    • Kumari, G., P. K. Singhal, M. R. Rao, and S. Mahalingam. 2007. Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals. J. Mol. Biol. 367:1294-1311.
    • (2007) J. Mol. Biol. , vol.367 , pp. 1294-1311
    • Kumari, G.1    Singhal, P.K.2    Rao, M.R.3    Mahalingam, S.4
  • 31
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • Malumbres, M., and M. Barbacid. 2003. RAS oncogenes: the first 30 years. Nat. Rev. Cancer 3:459-465.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 36
    • 33845451110 scopus 로고    scopus 로고
    • Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers
    • Park, H. W., H. C. Kang, I. J. Kim, S. G. Jang, K. Kim, H. J. Yoon, S. Y. Jeong, and J. G. Park. 2007. Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers. Int. J. Cancer 120:7-12.
    • (2007) Int. J. Cancer , vol.120 , pp. 7-12
    • Park, H.W.1    Kang, H.C.2    Kim, I.J.3    Jang, S.G.4    Kim, K.5    Yoon, H.J.6    Jeong, S.Y.7    Park, J.G.8
  • 37
    • 58249105729 scopus 로고    scopus 로고
    • K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse
    • Pearson, H. B., T. J. Phesse, and A. R. Clarke. 2009. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res. 69:94-101.
    • (2009) Cancer Res. , vol.69 , pp. 94-101
    • Pearson, H.B.1    Phesse, T.J.2    Clarke, A.R.3
  • 38
    • 20744447485 scopus 로고    scopus 로고
    • Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells
    • Pruitt, K., A. S. Ulku, K. Frantz, R. J. Rojas, V. M. Muniz-Medina, V. M. Rangnekar, C. J. Der, and J. M. Shields. 2005. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J. Biol. Chem. 280:23363-23370.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23363-23370
    • Pruitt, K.1    Ulku, A.S.2    Frantz, K.3    Rojas, R.J.4    Muniz-Medina, V.M.5    Rangnekar, V.M.6    Der, C.J.7    Shields, J.M.8
  • 39
    • 0008881181 scopus 로고    scopus 로고
    • Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4
    • Qiu, G., M. Ahmed, S. F. Sells, M. Mohiuddin, M. H. Weinstein, and V. M. Rangnekar. 1999. Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4. Oncogene 18:623-631.
    • (1999) Oncogene , vol.18 , pp. 623-631
    • Qiu, G.1    Ahmed, M.2    Sells, S.F.3    Mohiuddin, M.4    Weinstein, M.H.5    Rangnekar, V.M.6
  • 44
    • 34548220076 scopus 로고    scopus 로고
    • The Ras-association domain family (RASSF) members and their role in human tumourigenesis
    • van der Weyden, L., and D. J. Adams. 2007. The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim. Biophys. Acta 1776:58-85.
    • (2007) Biochim. Biophys. Acta , vol.1776 , pp. 58-85
    • Van Der Weyden, L.1    Adams, D.J.2
  • 46
    • 0034680870 scopus 로고    scopus 로고
    • Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis
    • Vos, M. D., C. A. Ellis, A. Bell, M. J. Birrer, and G. J. Clark. 2000. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J. Biol. Chem. 275:35669-35672.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35669-35672
    • Vos, M.D.1    Ellis, C.A.2    Bell, A.3    Birrer, M.J.4    Clark, G.J.5
  • 47
    • 0041845273 scopus 로고    scopus 로고
    • RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor
    • Vos, M. D., C. A. Ellis, C. Elam, A. S. Ulku, B. J. Taylor, and G. J. Clark. 2003. RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. J. Biol. Chem. 278:28045-28051.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28045-28051
    • Vos, M.D.1    Ellis, C.A.2    Elam, C.3    Ulku, A.S.4    Taylor, B.J.5    Clark, G.J.6
  • 48
    • 33845400874 scopus 로고    scopus 로고
    • Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma
    • Zhang, Z., D. Sun, N. Van do, A. Tang, L. Hu, and G. Huang. 2007. Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Int. J. Cancer. 120:32-38.
    • (2007) Int. J. Cancer , vol.120 , pp. 32-38
    • Zhang, Z.1    Sun, D.2    Van Do, N.3    Tang, A.4    Hu, L.5    Huang, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.