Synthesis of α, β-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: Characterization, molecular modeling, QSAR studies and effect against amyloid β-induced cytotoxicity

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 355-365

  Bukhari, Syed Nasir Abbas ^a   Jantan, Ibrahim ^a   Masand, Vijay H ^b   Mahajan, Devidas T ^b   Sher, Muhammad ^c   Naeem Ul Hassan, M ^c   Amjad, Muhammad Wahab ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b Department of Chemistry Vidya Bharati Mahavidyalaya ^*  (India)

^c UNIVERSITY OF SARGODHA   (Pakistan)

Author keywords

4 Piperidone; Alzheimer's disease; Neuroprotection; Oxidative stress; Synthesis

Indexed keywords

1 BENZYL 3,5 BIS (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE)PIPERIDIN 4 ONE; 1 BENZYL 3,5 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE]PIPERIDIN 4 ONE; 1,5 BIS (4 DIETHOXYMETHYL PHENYL)PENTA 1,4 DIEN 3 ONE; 1,5 BIS (4 DIMETHYLAMINO 2 NITRO PHENYL)PENTA 1,4 DIEN 3 ONE; 2 (4 DIETHOXYMETHYL BENZYLIDENE) 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2 (4 DIETHOXYMETHYL BENZYLIDENE) INDAN 1 ONE; 2 (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE) 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2 (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE)INDAN 1 ONE; 2 [3 (4 DIMETHYLAMINO 2 NITRO PHENYL) ACRYLOYL] 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2,5 BIS (4 DIETHOXYMETHYL BENZYLIDENE) CYCLOPENTANONE; 2,5 BIS (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE)CYCLOPENTANONE; 2,6 BIS (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE)CYCLOHEXANONE; 2,6 BIS (4 PYRROLIDIN 1 YL BENZYLIDENE)CYCLOHEXANONE; 2,6 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE]CYCLOHEXANONE; 2-[3 (4 DIETHOXYMETHYL PHENYL) ACRYLOYL] 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 3,5 BIS (4 DIETHOXYMETHYL BENZYLIDENE) TETRAHYDRO PYRAN 4 ONE; 3,5 BIS (4 PYRROLIDIN 1 YL BENZYLIDENE) PIPERIDIN 4 ONE; 3,5 BIS (4 PYRROLIDIN 1 YL BENZYLIDENE) TETRAHYDRO PYRAN 4 ONE; 3,5 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE] 1 METHYL PIPERIDIN 4 ONE; 3,5 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE]PIPERIDIN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO)2 NITRO BENZYLIDENE] 1 METHYL PIPERIDIN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO)2 NITRO BENZYLIDENE]PIPERIDIN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO)2 NITRO BENZYLIDENE]TETRAHYDRO PYRAN 4 ONE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CARBONYL DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1 BENZYL 3,5 BIS (4 PYRROLIDIN 1 YL BENZYLIDENE) PIPERIDIN 4 ONE; 1,5 BIS (4 DIMETHYLAMINO 2 NITRO PHENYL) PENTA 1,4 DIEN 3 ONE; 1,5 BIS (4 PYRROLIDIN 1 YL PHENYL) PENTA 1,4 DIEN 3 ONE; 1,5 BIS(4 DIETHOXYMETHYL PHENYL) PENTA 1,4 DIEN 3 ONE; 2 (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE) INDAN 1 ONE; 2 [3 (4 DIETHOXYMETHYL PHENYL) ACRYLOYL] 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2,5 BIS (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE) CYCLOPENTANONE; 2,5 BIS(4 DIETHOXYMETHYL BENZYLIDENE) CYCLOPENTANONE; 2,6 BIS (4 PYRROLIDIN 1 YL BENZYLIDENE) CYCLOHEXANONE; 2,6 BIS(4 DIMETHYLAMINO 2 NITRO BENZYLIDENE) CYCLOHEXANONE; 3,5 BIS(4 DIETHOXYMETHYL BENZYLIDENE) TETRAHYDRO PYRAN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO) 2 NITRO BENZYLIDENE] 1 METHYL PIPERIDIN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO) 2 NITRO BENZYLIDENE]PIPERIDIN 4 ONE; ANTIOXIDANT; NEUROPROTECTIVE AGENT; KETONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; FREE RADICAL SCAVENGING ASSAY; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SCAVENGING SYSTEM; ANIMAL CELL CULTURE; CELL DAMAGE; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG CYTOTOXICITY; DRUG POTENCY; ENZYME INHIBITION; IC50; LIPOPHILICITY; NERVE CELL; OXIDATION KINETICS; POLYMERIZATION; ANIMAL; CHEMISTRY; ENZYME ACTIVE SITE; GREEN CHEMISTRY; METABOLISM; SYNTHESIS;

ACETYLCHOLINESTERASE; AMYLOID BETA-PEPTIDES; ANIMALS; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; GREEN CHEMISTRY TECHNOLOGY; INHIBITORY CONCENTRATION 50; KETONES; MOLECULAR DOCKING SIMULATION; NEUROPROTECTIVE AGENTS; PC12 CELLS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS;

EID: 84903625560     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.034     Document Type: Article

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