-
1
-
-
0015721940
-
Cytosine arabinoside (NSC-63878) and daunorubicin (NSC-83142) therapy in acute nonlymphocytic leukemia
-
Yates JW, Wallace Jr HJ, Ellison RR, Holland JF. Cytosine arabinoside (NSC-63878) and daunorubicin (NSC-83142) therapy in acute nonlymphocytic leukemia. Cancer Chemother Rep. 1973;57(4):485-8.
-
(1973)
Cancer Chemother Rep
, vol.57
, Issue.4
, pp. 485-488
-
-
Yates, J.W.1
Wallace Jr., H.J.2
Ellison, R.R.3
Holland, J.F.4
-
2
-
-
70349451999
-
High-dose daunorubicin in older patients with acute myeloid leukemia
-
Lowenberg B, Ossenkoppele GJ, van Putten W, et al. High-dose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med. 2009;361(13):1235-48.
-
(2009)
N Engl J Med
, vol.361
, Issue.13
, pp. 1235-1248
-
-
Lowenberg, B.1
Ossenkoppele, G.J.2
Van Putten, W.3
-
3
-
-
70349467775
-
Anthracycline dose intensification in acute myeloid leukemia
-
This study showed a survival benefit with higher dose daunorubicin in younger patients
-
•• Fernandez HF, Sun Z, Yao X, et al. Anthracycline dose intensification in acute myeloid leukemia. N Engl J Med. 2009;361(13): 1249-59. This study showed a survival benefit with higher dose daunorubicin in younger patients
-
(2009)
N Engl J Med
, vol.361
, Issue.13
, pp. 1249-1259
-
-
Fernandez, H.F.1
Sun, Z.2
Yao, X.3
-
4
-
-
79952808421
-
Cytarabine dose for acute myeloid leukemia
-
Lowenberg B, Pabst T, Vellenga E, et al. Cytarabine dose for acute myeloid leukemia. N Engl J Med. 2011;364(11):1027-36.
-
(2011)
N Engl J Med
, vol.364
, Issue.11
, pp. 1027-1036
-
-
Lowenberg, B.1
Pabst, T.2
Vellenga, E.3
-
5
-
-
0027941369
-
Intensive postremission chemotherapy in adults with acute myeloid leukemia
-
DOI 10.1056/NEJM199410063311402
-
Mayer RJ, Davis RB, Schiffer CA, et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. N Engl J Med. 1994;331(14):896-903. (Pubitemid 24299870)
-
(1994)
New England Journal of Medicine
, vol.331
, Issue.14
, pp. 896-903
-
-
Mayer, R.J.1
Davis, R.B.2
Schiffer, C.A.3
Berg, D.T.4
Powell, B.L.5
Schulman, P.6
Omura, G.A.7
Moore, J.O.8
McIntyre, O.R.9
Frei III, E.10
-
6
-
-
0032793987
-
Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered
-
Byrd JC, Dodge RK, Carroll A, et al. Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered. J Clin Oncol. 1999;17(12):3767-75.
-
(1999)
J Clin Oncol
, vol.17
, Issue.12
, pp. 3767-3775
-
-
Byrd, J.C.1
Dodge, R.K.2
Carroll, A.3
-
7
-
-
0005040904
-
A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute myeloid leukaemia
-
Wheatley D, Dutcher J,Wiernik P, et al. A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute myeloid leukaemia. Br J Haematol. 1998;103(1):100-9.
-
(1998)
Br J Haematol
, vol.103
, Issue.1
, pp. 100-109
-
-
Wheatley, D.1
Dutcher, J.2
Wiernik, P.3
-
8
-
-
1842614240
-
Repetitive cycles of high-dose cytarabine benefit patients with acute myeloid leukemia and inv(16)(p13q22) or t(16;16)(p13;q22): Results from CALGB 8461
-
DOI 10.1200/JCO.2004.07.012
-
Byrd JC, Ruppert AS, Mrozek K, et al. Repetitive cycles of highdose cytarabine benefit patients with acute myeloid leukemia and inv(16)(p13q22) or t(16;16)(p13;q22): results from CALGB 8461. J Clin Oncol. 2004;22(6):1087-94. (Pubitemid 41095042)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.6
, pp. 1087-1094
-
-
Byrd, J.C.1
Ruppert, A.S.2
Mrozek, K.3
Carroll, A.J.4
Edwards, C.G.5
Arthur, D.C.6
Pettenati, M.J.7
Stamberg, J.8
Koduru, P.R.K.9
Moore, J.O.10
Mayer, R.J.11
Davey, F.R.12
Larson, R.A.13
Bloomfield, C.D.14
-
9
-
-
84863393263
-
Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
-
Patel JP, Gönen M, Figueroa ME, et al. Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia. N Engl J Med. 2012;366(12):1079-89.
-
(2012)
N Engl J Med
, vol.366
, Issue.12
, pp. 1079-1089
-
-
Patel, J.P.1
Gönen, M.2
Figueroa, M.E.3
-
10
-
-
84979796721
-
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia
-
Smith CC, Shah NP. The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. Am Soc Clin Oncol Educ Book. 2013;2013:313-8.
-
(2013)
Am Soc Clin Oncol Educ Book
, vol.2013
, pp. 313-318
-
-
Smith, C.C.1
Shah, N.P.2
-
11
-
-
79952092487
-
Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
-
Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol. 2011;29(5):475-86.
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 475-486
-
-
Marcucci, G.1
Haferlach, T.2
Dohner, H.3
-
12
-
-
80052231301
-
FLT3 inhibition as therapy in acute myeloid leukemia: A record of trials and tribulations
-
Fathi AT, Chabner BA. FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulations. Oncologist. 2011;16(8):1162-74.
-
(2011)
Oncologist
, vol.16
, Issue.8
, pp. 1162-1174
-
-
Fathi, A.T.1
Chabner, B.A.2
-
13
-
-
0027955112
-
+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
-
Small D, Levenstein M, Kim E, et al. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A. 1994;91(2): 459-63. (Pubitemid 24041421)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.2
, pp. 459-463
-
-
Small, D.1
Levenstein, M.2
Kim, E.3
Carow, C.4
Amin, S.5
Rockwell, P.6
Witte, L.7
Burrow, C.8
Ratajczak, M.Z.9
Gewirtz, A.M.10
Civin, C.I.11
-
14
-
-
0036624916
-
A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
-
DOI 10.1182/blood.V99.11.3885
-
Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99(11):3885-91. (Pubitemid 35332023)
-
(2002)
Blood
, vol.99
, Issue.11
, pp. 3885-3891
-
-
Levis, M.1
Allebach, J.2
Tse, K.-F.3
Zheng, R.4
Brenda, R.5
Baldwin, B.6
Smith, D.7
Jones-Bolin, S.8
Ruggeri, B.9
Dionne, C.10
Small, D.11
-
15
-
-
0034554796
-
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
-
Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96(12): 3907-14.
-
(2000)
Blood
, vol.96
, Issue.12
, pp. 3907-3914
-
-
Mizuki, M.1
Fenski, R.2
Halfter, H.3
-
16
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acutemyeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acutemyeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98(6):1752-9.
-
(2001)
Blood
, vol.98
, Issue.6
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
-
17
-
-
0036720398
-
The roles of FLT3 in hematopoiesis and leukemia
-
DOI 10.1182/blood-2002-02-0492
-
Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100(5):1532-42. (Pubitemid 34925124)
-
(2002)
Blood
, vol.100
, Issue.5
, pp. 1532-1542
-
-
Gary, G.D.1
Griffin, J.D.2
-
18
-
-
0031686409
-
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
-
Kiyoi H, Towatari M,Yokota S, et al. Internal tandemduplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12(9):1333-7. (Pubitemid 28442377)
-
(1998)
Leukemia
, vol.12
, Issue.9
, pp. 1333-1337
-
-
Kiyoi, H.1
Towatari, M.2
Yokota, S.3
Hamaguchi, M.4
Ohno, R.5
Saito, H.6
Naoe, T.7
-
19
-
-
0036786289
-
Internal tandem duplication of FLT3 in relapsed acutemyeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse
-
Shih LY, Huang CF, Wu JH, et al. Internal tandem duplication of FLT3 in relapsed acutemyeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse. Blood. 2002;100(7):2387-92.
-
(2002)
Blood
, vol.100
, Issue.7
, pp. 2387-2392
-
-
Shih, L.Y.1
Huang, C.F.2
Wu, J.H.3
-
20
-
-
62949087552
-
A pharmacodynamic study of the FLT3 inhibitorKW-2449 yields insight into the basis for clinical response
-
Pratz KW, Cortes J, Roboz GJ, et al. A pharmacodynamic study of the FLT3 inhibitorKW-2449 yields insight into the basis for clinical response. Blood. 2009;113(17):3938-46.
-
(2009)
Blood
, vol.113
, Issue.17
, pp. 3938-3946
-
-
Pratz, K.W.1
Cortes, J.2
Roboz, G.J.3
-
21
-
-
39149129114
-
Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia
-
DOI 10.1093/jnci/djm328
-
Zhang W, Konopleva M, Shi Y-x, et al. Mutant FLT3: A Direct Target of Sorafenib in Acute Myelogenous Leukemia. J Natl Cancer Inst. 2008;100(3):184-98. (Pubitemid 351480557)
-
(2008)
Journal of the National Cancer Institute
, vol.100
, Issue.3
, pp. 184-198
-
-
Zhang, W.1
Konopleva, M.2
Shi, Y.-X.3
McQueen, T.4
Harris, D.5
Ling, X.6
Estrov, Z.7
Quintas-Cardama, A.8
Small, D.9
Cortes, J.10
Andreeff, M.11
-
22
-
-
57449110921
-
Potential role of sorafenib in the treatment of acute myeloid leukemia
-
Mori S, Cortes J, Kantarjian H, Zhang W, Andreef M, Ravandi F. Potential role of sorafenib in the treatment of acute myeloid leukemia. Leuk Lymphoma. 2008;49(12):2246-55.
-
(2008)
Leuk Lymphoma
, vol.49
, Issue.12
, pp. 2246-2255
-
-
Mori, S.1
Cortes, J.2
Kantarjian, H.3
Zhang, W.4
Andreef, M.5
Ravandi, F.6
-
23
-
-
42349087045
-
Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway
-
DOI 10.1038/sj.leu.2405098, PII 2405098
-
Zhang W, Konopleva M, Ruvolo VR, et al. Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia. 2008;22(4):808-18. (Pubitemid 351552630)
-
(2008)
Leukemia
, vol.22
, Issue.4
, pp. 808-818
-
-
Zhang, W.1
Konopleva, M.2
Ruvolo, V.R.3
McQueen, T.4
Evans, R.L.5
Bornmann, W.G.6
McCubrey, J.7
Cortes, J.8
Andreeff, M.9
-
24
-
-
77951645227
-
Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia
-
Ravandi F, Cortes JE, Jones D, et al. Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia. J Clin Oncol. 2010;28(11):1856 -62.
-
(2010)
J Clin Oncol
, vol.28
, Issue.11
, pp. 1856-1862
-
-
Ravandi, F.1
Cortes, J.E.2
Jones, D.3
-
25
-
-
76349102339
-
A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: A NCIC (National Cancer Institute of Canada) Clinical Trials Group Study
-
Crump M, Hedley D, Kamel-Reid S, et al. A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study. Leuk Lymphoma. 2010;51(2): 252-60.
-
(2010)
Leuk Lymphoma
, vol.51
, Issue.2
, pp. 252-260
-
-
Crump, M.1
Hedley, D.2
Kamel-Reid, S.3
-
26
-
-
84861906112
-
Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: Favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation
-
Man CH, Fung TK, Ho C, et al. Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood. 2012;119(22):5133-43.
-
(2012)
Blood
, vol.119
, Issue.22
, pp. 5133-5143
-
-
Man, C.H.1
Fung, T.K.2
Ho, C.3
-
27
-
-
84879150977
-
A phase I/II study of sorafenib in combination with low dose cytarabine in elderly patients with acute myeloid leukemia or high-risk myelodysplastic syndrome from the National Cancer Institute of Canada Clinical Trials Group: Trial IND.186
-
Macdonald DA, Assouline SE, Brandwein J, et al. A phase I/II study of sorafenib in combination with low dose cytarabine in elderly patients with acute myeloid leukemia or high-risk myelodysplastic syndrome from the National Cancer Institute of Canada Clinical Trials Group: trial IND.186. Leuk Lymphoma. 2013;54(4):760-6.
-
(2013)
Leuk Lymphoma
, vol.54
, Issue.4
, pp. 760-766
-
-
Macdonald, D.A.1
Assouline, S.E.2
Brandwein, J.3
-
28
-
-
84881035623
-
Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation
-
Ravandi F, Alattar ML, Grunwald MR, et al. Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation. Blood. 2013;121(23):4655-62.
-
(2013)
Blood
, vol.121
, Issue.23
, pp. 4655-4662
-
-
Ravandi, F.1
Alattar, M.L.2
Grunwald, M.R.3
-
29
-
-
84886534519
-
Sorafenib in CombinationWith Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial
-
Serve H, Krug U, Wagner R, et al. Sorafenib in CombinationWith Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial. J Clin Oncol. 2013;31(25):3110-18.
-
(2013)
J Clin Oncol
, vol.31
, Issue.25
, pp. 3110-3118
-
-
Serve, H.1
Krug, U.2
Wagner, R.3
-
30
-
-
81155153252
-
Patterns of Molecular Response to and Relapse After Combination of Sorafenib, Idarubicin, and Cytarabine in Patients With FLT3 Mutant Acute Myeloid Leukemia
-
Al-Kali A, Cortes J, Faderl S, et al. Patterns of Molecular Response to and Relapse After Combination of Sorafenib, Idarubicin, and Cytarabine in Patients With FLT3 Mutant Acute Myeloid Leukemia. Clinical LymphomaMyeloma Leuk. 2011;11(4):361-6.
-
(2011)
Clinical LymphomaMyeloma Leuk
, vol.11
, Issue.4
, pp. 361-366
-
-
Al-Kali, A.1
Cortes, J.2
Faderl, S.3
-
31
-
-
84875627695
-
Sorafenib Versus Placebo in Addition to Standard Therapy in Adult Patients >=60 Years with Newly Diagnosed Acute Myeloid Leukemia: Results From the Randomized-Controlled Soraml Trial
-
Rollig C, Muller-Tidow C, Huttmann A, et al. Sorafenib Versus Placebo in Addition to Standard Therapy in Adult Patients >=60 Years with Newly Diagnosed Acute Myeloid Leukemia: Results From the Randomized-Controlled Soraml Trial. ASH Annu Meet Abstr. 2012;120(21):144.
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 144
-
-
Rollig, C.1
Muller-Tidow, C.2
Huttmann, A.3
-
32
-
-
84903637127
-
Final Report of Combination of Sorafenib, Idarubicin, and Cytarabine for Initial Therapy in Younger Patients with Acute Myeloid Leukemia
-
Yi CYA, Cortes J, Faderl S, et al. Final Report of Combination of Sorafenib, Idarubicin, and Cytarabine for Initial Therapy in Younger Patients with Acute Myeloid Leukemia. ASH Annu Meet Abstr. 2012;120(21):1516.
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 1516
-
-
Yi, C.Y.A.1
Cortes, J.2
Faderl, S.3
-
33
-
-
3843142735
-
In vitro studies of a FLT3 inhibitor combined with chemotherapy: Sequence of administration is important to achieve synergistic cytotoxic effects
-
DOI 10.1182/blood-2004-01-0388
-
Levis M, Pham R, Smith BD, Small D. In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects. Blood. 2004;104(4):1145-50. (Pubitemid 39038036)
-
(2004)
Blood
, vol.104
, Issue.4
, pp. 1145-1150
-
-
Levis, M.1
Pham, R.2
Smith, B.D.3
Small, D.4
-
34
-
-
19944427559
-
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
-
DOI 10.1182/blood-2004-03-0891
-
Stone RM, DeAngelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood. 2005;105(1):54-60. (Pubitemid 40053063)
-
(2005)
Blood
, vol.105
, Issue.1
, pp. 54-60
-
-
Stone, R.M.1
DeAngelo, D.J.2
Klimek, V.3
Galinsky, I.4
Estey, E.5
Nimer, S.D.6
Grandin, W.7
Lebwohl, D.8
Wang, Y.9
Cohen, P.10
Fox, E.A.11
Neuberg, D.12
Clark, J.13
Gilliland, D.G.14
Griffin, J.D.15
-
35
-
-
78049426367
-
Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) andMulti-Targeted Kinase Inhibitor, in PatientsWith Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3
-
Fischer T, Stone RM, DeAngelo DJ, et al. Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) andMulti-Targeted Kinase Inhibitor, in PatientsWith Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3. J Clin Oncol. 2010;28(28):4339-45.
-
(2010)
J Clin Oncol
, vol.28
, Issue.28
, pp. 4339-4345
-
-
Fischer, T.1
Stone, R.M.2
DeAngelo, D.J.3
-
36
-
-
84895490922
-
Preclinical and Phase I Results of Decitabine in Combination with Midostaurin (PKC412) for Newly Diagnosed Elderly or Relapsed/Refractory Adult Patients with Acute Myeloid Leukemia
-
Williams CB, Kambhampati S, Fiskus W, et al. Preclinical and Phase I Results of Decitabine in Combination with Midostaurin (PKC412) for Newly Diagnosed Elderly or Relapsed/Refractory Adult Patients with Acute Myeloid Leukemia. Pharmacother: J Hum Pharmacol Drug Ther. 2013;33(12)1341-52.
-
(2013)
Pharmacother: J Hum Pharmacol Drug Ther
, vol.33
, Issue.12
, pp. 1341-1352
-
-
Williams, C.B.1
Kambhampati, S.2
Fiskus, W.3
-
37
-
-
84902342216
-
A Phase I/II Trial of Combination of Midostaurin (PKC412) and 5-Azacytidine (5- AZA) for the Treatment of Patients with Refractory or Relapsed (R/R) Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
-
Nazha A, Kantarjian HM, Borthakur G, et al. A Phase I/II Trial of Combination of Midostaurin (PKC412) and 5-Azacytidine (5- AZA) for the Treatment of Patients with Refractory or Relapsed (R/R) Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS). ASH Annu Meet Abstr. 2012;120(21):3587.
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 3587
-
-
Nazha, A.1
Kantarjian, H.M.2
Borthakur, G.3
-
38
-
-
84865865542
-
Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia
-
Stone RM, Fischer T, Paquette R, et al. Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia. Leukemia. 2012;26(9):2061-8.
-
(2012)
Leukemia
, vol.26
, Issue.9
, pp. 2061-2068
-
-
Stone, R.M.1
Fischer, T.2
Paquette, R.3
-
39
-
-
70449475105
-
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
-
Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009;114(14):2984-92.
-
(2009)
Blood
, vol.114
, Issue.14
, pp. 2984-2992
-
-
Zarrinkar, P.P.1
Gunawardane, R.N.2
Cramer, M.D.3
-
40
-
-
84875635430
-
Final Results of a Phase 2 Open-Label, Monotherapy Efficacy and Safety Study of Quizartinib (AC220) in Patients with FLT3-ITD Positive or Negative Relapsed/Refractory Acute Myeloid Leukemia After Second-Line Chemotherapy or Hematopoietic Stem Cell Transplantation
-
This study showed good responses with Quizartinib which is the most potent FLT3 inhibitor
-
• Levis MJ, Perl AE, Dombret H, et al. Final Results of a Phase 2 Open-Label, Monotherapy Efficacy and Safety Study of Quizartinib (AC220) in Patients with FLT3-ITD Positive or Negative Relapsed/Refractory Acute Myeloid Leukemia After Second-Line Chemotherapy or Hematopoietic Stem Cell Transplantation. ASH Annu Meet Abstr. 2012;120(21):673. This study showed good responses with Quizartinib which is the most potent FLT3 inhibitor
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 673
-
-
Levis, M.J.1
Perl, A.E.2
Dombret, H.3
-
41
-
-
84903609997
-
Effect of quizartinib (AC220) on response rates and long-term survival in elderly patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia
-
Martinelli G, Perl AE, Dombret H, et al. Effect of quizartinib (AC220) on response rates and long-term survival in elderly patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia. ASCO Meet Abstr. 2013;31(15-suppl):7021.
-
(2013)
ASCO Meet Abstr
, vol.31
, Issue.15 SUPPL.
, pp. 7021
-
-
Martinelli, G.1
Perl, A.E.2
Dombret, H.3
-
42
-
-
84887805195
-
Efficacy and safety of quizartinib (AC220) in patients age >= 70 years with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia (AML)
-
Perl AE, Dohner H, Rousselot PH, et al. Efficacy and safety of quizartinib (AC220) in patients age >= 70 years with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia (AML). ASCO Meet Abstr. 2013;31(15-suppl):7023.
-
(2013)
ASCO Meet Abstr
, vol.31
, Issue.15 SUPPL.
, pp. 7023
-
-
Perl, A.E.1
Dohner, H.2
Rousselot, P.H.3
-
43
-
-
84655164874
-
A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours
-
Schöffski P, Awada A, Dumez H, et al. A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours. Eur J Cancer. 2012;48(2):179-86.
-
(2012)
Eur J Cancer
, vol.48
, Issue.2
, pp. 179-186
-
-
Schöffski, P.1
Awada, A.2
Dumez, H.3
-
44
-
-
84872211853
-
Phase I/II Study of Volasertib (BI 6727), An Intravenous Polo-Like Kinase (Plk) Inhibitor, in Patients with Acute Myeloid Leukemia (AML): Updated Results of the Dose Finding Phase I Part for Volasertib in Combination with Low-Dose Cytarabine (LD-Ara-C) and As Monotherapy in Relapsed/Refractory AML
-
Bug G, Muller-Tidow C, Schlenk RF, et al. Phase I/II Study of Volasertib (BI 6727), An Intravenous Polo-Like Kinase (Plk) Inhibitor, in Patients with Acute Myeloid Leukemia (AML): Updated Results of the Dose Finding Phase I Part for Volasertib in Combination with Low-Dose Cytarabine (LD-Ara-C) and As Monotherapy in Relapsed/Refractory AML. ASH Annu Meet Abstr. 2011;118(21):1549.
-
(2011)
ASH Annu Meet Abstr
, vol.118
, Issue.21
, pp. 1549
-
-
Bug, G.1
Muller-Tidow, C.2
Schlenk, R.F.3
-
45
-
-
84874106884
-
Phase I/II Study of Volasertib (BI 6727), an Intravenous Polo-Like Kinase (Plk) Inhibitor, in Patients with Acute Myeloid Leukemia (AML): Results From the Randomized Phase II Part for Volasertib in Combination with Low-Dose Cytarabine (LDAC) Versus LDAC Monotherapy in Patients with Previously Untreated AML Ineligible for Intensive Treatment
-
Maertens J, Lubbert M, Fiedler W, et al. Phase I/II Study of Volasertib (BI 6727), an Intravenous Polo-Like Kinase (Plk) Inhibitor, in Patients with Acute Myeloid Leukemia (AML): Results From the Randomized Phase II Part for Volasertib in Combination with Low-Dose Cytarabine (LDAC) Versus LDAC Monotherapy in Patients with Previously Untreated AML Ineligible for Intensive Treatment. ASH Annu Meet Abstr. 2012;120(21):411.
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 411
-
-
Maertens, J.1
Lubbert, M.2
Fiedler, W.3
-
46
-
-
34547650860
-
Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: A phase II trial in adults with poor-risk acute myelogenous leukemia
-
DOI 10.1158/1078-0432.CCR-07-0381
-
Karp JE, Smith BD, Levis MJ, et al. Sequential Flavopiridol, Cytosine Arabinoside, and Mitoxantrone: A Phase II Trial in Adults with Poor-Risk Acute Myelogenous Leukemia. Clin Cancer Res. 2007;13(15):4467-73. (Pubitemid 47219715)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.15
, pp. 4467-4473
-
-
Karp, J.E.1
Smith, B.D.2
Levis, M.J.3
Gore, S.D.4
Greer, J.5
Hattenburg, C.6
Briel, J.7
Jones, R.J.8
Wright, J.J.9
Colevas, A.D.10
-
47
-
-
28544443503
-
Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias
-
DOI 10.1158/1078-0432.CCR-05-1201
-
Karp JE, Passaniti A, Gojo I, et al. Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-Darabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias. Clin Cancer Res. 2005;11(23):8403-12. (Pubitemid 41746954)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.23
, pp. 8403-8412
-
-
Karp, J.E.1
Passaniti, A.2
Gojo, I.3
Kaufmann, S.4
Bible, K.5
Garimella, T.S.6
Greer, J.7
Briel, J.8
Smith, B.D.9
Gore, S.D.10
Tidwell, M.L.11
Ross, D.D.12
Wright, J.J.13
Colevas, A.D.14
Bauer, K.S.15
-
48
-
-
77952902915
-
Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia
-
This study showed good responses in FLT3 mutated patients with FLAM
-
• Karp JE, Blackford A, Smith BD, et al. Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. Leuk Res. 2010;34(7):877-82. This study showed good responses in FLT3 mutated patients with FLAM
-
(2010)
Leuk Res
, vol.34
, Issue.7
, pp. 877-882
-
-
Karp, J.E.1
Blackford, A.2
Smith, B.D.3
-
49
-
-
84891658807
-
Randomized Phase II Trial of Timed-Sequential Therapy (TST) with Flavopiridol (Alvocidib), Ara-C and Mitoxantrone (FLAM) Versus "7+3" for Adults Ages 70 Years and Under with Newly Diagnosed Acute Myeloid Leukemia (AML)
-
Zeidner JF, Gerber JM, Blackford A, et al. Randomized Phase II Trial of Timed-Sequential Therapy (TST) with Flavopiridol (Alvocidib), Ara-C and Mitoxantrone (FLAM) Versus "7+3" for Adults Ages 70 Years and Under with Newly Diagnosed Acute Myeloid Leukemia (AML). ASH AnnuMeet Abstr. 2012;120(21): 47.
-
(2012)
ASH AnnuMeet Abstr
, vol.120
, Issue.21
, pp. 47
-
-
Zeidner, J.F.1
Gerber, J.M.2
Blackford, A.3
-
50
-
-
83555165090
-
A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia
-
Lancet JE, Ravandi F, Ricklis RM, et al. A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia. Leukemia. 2011;25(12):1808-14.
-
(2011)
Leukemia
, vol.25
, Issue.12
, pp. 1808-1814
-
-
Lancet, J.E.1
Ravandi, F.2
Ricklis, R.M.3
-
51
-
-
77956304709
-
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II
-
Hawtin RE, Stockett DE, Byl JA, et al. Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One. 2010;5(4):e10186.
-
(2010)
PLoS One
, vol.5
, Issue.4
-
-
Hawtin, R.E.1
Stockett, D.E.2
Byl, J.A.3
-
52
-
-
77956228014
-
Voreloxin, a first-inclass anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo
-
Scatena CD, Kumer JL, Arbitrario JP, et al. Voreloxin, a first-inclass anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010;66(5):881-8.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, Issue.5
, pp. 881-888
-
-
Scatena, C.D.1
Kumer, J.L.2
Arbitrario, J.P.3
-
53
-
-
84878888283
-
Final results of a phase II pharmacokinetic/pharmacodynamic (PK/PD) study of combination voreloxin and cytarabine in patients with relapsed or refractory acute myeloid leukemia
-
Roboz GJ, Lancet JE, Cripe LD, et al. Final results of a phase II pharmacokinetic/pharmacodynamic (PK/PD) study of combination voreloxin and cytarabine in patients with relapsed or refractory acute myeloid leukemia. ASCO Meet Abstr. 2010;28(15-suppl):6526.
-
(2010)
ASCO Meet Abstr
, vol.28
, Issue.15 SUPPL.
, pp. 6526
-
-
Roboz, G.J.1
Lancet, J.E.2
Cripe, L.D.3
-
54
-
-
80755126243
-
Voreloxin singleagent treatment of older patients (60 years or older) with previously untreated acute myeloid leukemia: Final results from a phase II study with three schedules
-
Stuart RK, Ravandi Kashani F, Cripe LD, et al. Voreloxin singleagent treatment of older patients (60 years or older) with previously untreated acute myeloid leukemia: Final results from a phase II study with three schedules. ASCO Meet Abstr. 2010;28(15-suppl):6525.
-
(2010)
ASCO Meet Abstr
, vol.28
, Issue.15 SUPPL.
, pp. 6525
-
-
Stuart, R.K.1
Ravandi Kashani, F.2
Cripe, L.D.3
-
55
-
-
77956319595
-
Phase 1b/2 Pharmacokinetic/ Pharmacodynamic (PK/PD) Study of Combination Voreloxin and Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia Patients
-
Lancet JE, Roboz GJ, Cripe LD, et al. Phase 1b/2 Pharmacokinetic/ Pharmacodynamic (PK/PD) Study of Combination Voreloxin and Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia Patients. ASH Annu Meet Abstr. 2009;114(22):635.
-
(2009)
ASH Annu Meet Abstr
, vol.114
, Issue.22
, pp. 635
-
-
Lancet, J.E.1
Roboz, G.J.2
Cripe, L.D.3
-
56
-
-
84878859644
-
Vosaroxin: A new valuable tool with the potential to replace anthracyclines in the treatment of AML?
-
Freeman C,KeaneN, Swords R,Giles F. Vosaroxin: a new valuable tool with the potential to replace anthracyclines in the treatment of AML? Expert Opin Pharmacother. 2013;14(10):1417-27.
-
(2013)
Expert Opin Pharmacother
, vol.14
, Issue.10
, pp. 1417-1427
-
-
Freeman, C.1
Keane, N.2
Swords, R.3
Giles, F.4
-
57
-
-
84863779790
-
Phase I and pharmacokinetic study of elacytarabine, a novel 5'-elaidic acid derivative of cytarabine, in adults with refractory hematological malignancies
-
Giles FJ, Vey N, Rizzieri D, et al. Phase I and pharmacokinetic study of elacytarabine, a novel 5'-elaidic acid derivative of cytarabine, in adults with refractory hematological malignancies. Leukemia. 2012;26(7):1686-9.
-
(2012)
Leukemia
, vol.26
, Issue.7
, pp. 1686-1689
-
-
Giles, F.J.1
Vey, N.2
Rizzieri, D.3
-
58
-
-
84857232432
-
Elacytarabine, a novel 5'-elaidic acid derivative of cytarabine, and idarubicin combination is active in refractory acute myeloid leukemia
-
Giles F, Rizzieri D, Ravandi F, Swords R, Jacobsen TF, O'Brien S. Elacytarabine, a novel 5'-elaidic acid derivative of cytarabine, and idarubicin combination is active in refractory acute myeloid leukemia. Leuk Res. 2012;36(4):e71-3.
-
(2012)
Leuk Res
, vol.36
, Issue.4
-
-
Giles, F.1
Rizzieri, D.2
Ravandi, F.3
Swords, R.4
Jacobsen, T.F.5
O'Brien, S.6
-
59
-
-
84865273611
-
Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia
-
O'Brien S, Rizzieri DA, Vey N, et al. Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia. Br J Haematol. 2012;158(5):581-8.
-
(2012)
Br J Haematol
, vol.158
, Issue.5
, pp. 581-588
-
-
O'Brien, S.1
Rizzieri, D.A.2
Vey, N.3
-
60
-
-
84881295322
-
Elacytarabine (CP- 4055) in the treatment of acute myeloid leukemia
-
Dinardo CD, O'Brien S, Gandhi VV, Ravandi F. Elacytarabine (CP- 4055) in the treatment of acute myeloid leukemia. Future Oncol. 2013;9(8):1073-82.
-
(2013)
Future Oncol
, vol.9
, Issue.8
, pp. 1073-1082
-
-
Dinardo, C.D.1
O'Brien, S.2
Gandhi, V.V.3
Ravandi, F.4
-
61
-
-
42049090008
-
Anti proliferative activity of ELACYT (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan an topotecan in human leukemia and lymphoma cells
-
DOI 10.1080/10428190801935752, PII 792010052
-
Adams DJ, SandvoldML,Myhren F, Jacobsen TF, Giles F, Rizzieri DA. Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leuk Lymphoma. 2008;49(4):786-97. (Pubitemid 351517226)
-
(2008)
Leukemia and Lymphoma
, vol.49
, Issue.4
, pp. 786-797
-
-
Adams, D.J.1
Sandvold, M.L.2
Myhren, F.3
Jacobsen, T.F.4
Giles, F.5
Rizzieri, D.A.6
-
62
-
-
1242286151
-
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines
-
DOI 10.1016/j.bcp.2003.09.028
-
Bergman AM, Kuiper CM, Voorn DA, et al. Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines. Biochem Pharmacol. 2004;67(3):503-11. (Pubitemid 38232890)
-
(2004)
Biochemical Pharmacology
, vol.67
, Issue.3
, pp. 503-511
-
-
Bergman, A.M.1
Kuiper, C.M.2
Voorn, D.A.3
Comijn, E.M.4
Myhren, F.5
Sandvold, M.L.6
Hendriks, H.R.7
Peters, G.J.8
-
63
-
-
84903608658
-
A Phase II Study of Elacytarabine/Idarubicin As Second Course Remission-Induction in Patients with Acute Myeloid Leukemia Who Failed Cytarabine/ Anthracycline
-
Rizzieri DA, Vey N, Thomas X, et al. A Phase II Study of Elacytarabine/Idarubicin As Second Course Remission-Induction in Patients with Acute Myeloid Leukemia Who Failed Cytarabine/ Anthracycline. ASH Annu Meet Abstr. 2012;120(21):46.
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 46
-
-
Rizzieri, D.A.1
Vey, N.2
Thomas, X.3
-
64
-
-
84868115075
-
Improving outcomes for elderly patients with AML
-
Russell NH. Improving outcomes for elderly patients with AML. Lancet Oncol. 2012;13(11):1065-6.
-
(2012)
Lancet Oncol
, vol.13
, Issue.11
, pp. 1065-1066
-
-
Russell, N.H.1
-
65
-
-
84868093252
-
Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: A randomised phase 2 study
-
This study showed good ORR and tolerability in elderly patients with AML
-
•• Kantarjian H, Faderl S, Garcia-Manero G, et al. Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 study. Lancet Oncol. 2012;13(11):1096-104. This study showed good ORR and tolerability in elderly patients with AML
-
(2012)
Lancet Oncol
, vol.13
, Issue.11
, pp. 1096-1104
-
-
Kantarjian, H.1
Faderl, S.2
Garcia-Manero, G.3
-
66
-
-
74949124273
-
Phase I Clinical and Pharmacokinetic Study of Oral Sapacitabine in Patients With Acute Leukemia and Myelodysplastic Syndrome
-
Kantarjian H, Garcia-Manero G, O'Brien S, et al. Phase I Clinical and Pharmacokinetic Study of Oral Sapacitabine in Patients With Acute Leukemia and Myelodysplastic Syndrome. J Clin Oncol. 2010;28(2):285-91.
-
(2010)
J Clin Oncol
, vol.28
, Issue.2
, pp. 285-291
-
-
Kantarjian, H.1
Garcia-Manero, G.2
O'Brien, S.3
-
67
-
-
84863239775
-
Phase I/II study of sapacitabine and decitabine administered sequentially in elderly patients with newly diagnosed acute myeloid leukemia
-
Ravandi F, Faderl S, Cortes JE, et al. Phase I/II study of sapacitabine and decitabine administered sequentially in elderly patients with newly diagnosed acute myeloid leukemia. ASCO Meet Abstr. 2011;29(15-suppl):6587.
-
(2011)
ASCO Meet Abstr
, vol.29
, Issue.15 SUPPL.
, pp. 6587
-
-
Ravandi, F.1
Faderl, S.2
Cortes, J.E.3
-
68
-
-
55049108527
-
In vivo maintenance of synergistic cytarabine:Daunorubicin ratios greatly enhances therapeutic efficacy
-
Tardi P, Johnstone S, Harasym N, et al. In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res. 2009;33(1):129-39.
-
(2009)
Leuk Res
, vol.33
, Issue.1
, pp. 129-139
-
-
Tardi, P.1
Johnstone, S.2
Harasym, N.3
-
69
-
-
79952757852
-
First-In-Man Study of CPX-351: A Liposomal Carrier Containing Cytarabine and Daunorubicin in a Fixed 5:1 Molar Ratio for the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
-
Feldman EJ, Lancet JE, Kolitz JE, et al. First-In-Man Study of CPX-351: A Liposomal Carrier Containing Cytarabine and Daunorubicin in a Fixed 5:1 Molar Ratio for the Treatment of Relapsed and Refractory Acute Myeloid Leukemia. J Clin Oncol. 2011;29(8):979- 85.
-
(2011)
J Clin Oncol
, vol.29
, Issue.8
, pp. 979-985
-
-
Feldman, E.J.1
Lancet, J.E.2
Kolitz, J.E.3
-
70
-
-
84865154500
-
Pharmacokinetics of CPX- 351; a nano-scale liposomal fixed molar ratio formulation of cytarabine:Daunorubicin, in patients with advanced leukemia
-
Feldman EJ, Kolitz JE, Trang JM, et al. Pharmacokinetics of CPX- 351; a nano-scale liposomal fixed molar ratio formulation of cytarabine:daunorubicin, in patients with advanced leukemia. Leuk Res. 2012;36(10):1283-9.
-
(2012)
Leuk Res
, vol.36
, Issue.10
, pp. 1283-1289
-
-
Feldman, E.J.1
Kolitz, J.E.2
Trang, J.M.3
-
71
-
-
84863968369
-
CPX-351: A Randomized Phase 2b Study of CPX-351 v. Intensive Salvage Therapy in '65 Yo First Relapse AML Patients: Initial Efficacy and Safety Report
-
Cortes JE, Feldman EJ, Goldberg SL, et al. CPX-351: A Randomized Phase 2b Study of CPX-351 v. Intensive Salvage Therapy in '65 Yo First Relapse AML Patients: Initial Efficacy and Safety Report. ASH Annu Meet Abstr. 2011;118(21):254.
-
(2011)
ASH Annu Meet Abstr
, vol.118
, Issue.21
, pp. 254
-
-
Cortes, J.E.1
Feldman, E.J.2
Goldberg, S.L.3
-
72
-
-
84887361430
-
CPX-351 Is Effective in Newly Diagnosed Older Patients with AML and with Multiple Risk Factors
-
This study showed good ORR in patients with secondary AML
-
• Lancet JE, Cortes JE, Kovacsovics T, et al. CPX-351 Is Effective in Newly Diagnosed Older Patients with AML and with Multiple Risk Factors. ASH Annu Meet Abstr. 2012;120(21):3626. This study showed good ORR in patients with secondary AML
-
(2012)
ASH Annu Meet Abstr
, vol.120
, Issue.21
, pp. 3626
-
-
Lancet, J.E.1
Cortes, J.E.2
Kovacsovics, T.3
-
73
-
-
84880245095
-
Gemtuzumab ozogamicin in acute myeloid leukemia: A remarkable saga about an active drug
-
Rowe JM, Löwenberg B. Gemtuzumab ozogamicin in acute myeloid leukemia: a remarkable saga about an active drug. Blood. 2013;121(24):4838-41.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4838-4841
-
-
Rowe, J.M.1
Löwenberg, B.2
-
74
-
-
84881305790
-
A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
-
Petersdorf SH, Kopecky KJ, Slovak M, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood. 2013;121(24):4854-60.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4854-4860
-
-
Petersdorf, S.H.1
Kopecky, K.J.2
Slovak, M.3
-
75
-
-
25144485908
-
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence
-
DOI 10.1002/cncr.21326
-
Larson RA, Sievers EL, Stadtmauer EA, et al. Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer. 2005;104(7):1442-52. (Pubitemid 41356159)
-
(2005)
Cancer
, vol.104
, Issue.7
, pp. 1442-1452
-
-
Larson, R.A.1
Sievers, E.L.2
Stadtmauer, E.A.3
Lowenberg, B.4
Estey, E.H.5
Dombret, H.6
Theobald, M.7
Voliotis, D.8
Bennett, J.M.9
Richte, M.10
Leopold, L.H.11
Berger, M.S.12
Sherman, M.L.13
Loken, M.R.14
Van Dongen, J.J.M.15
Bernstein, I.D.16
Appelbaum, F.R.17
-
76
-
-
84863522871
-
Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy Improves Survival in Older Patients With Acute Myeloid Leukemia
-
Burnett AK, Russell NH, Hills RK, et al. Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy Improves Survival in Older Patients With Acute Myeloid Leukemia. J Clin Oncol. 2012;30(32):3924-31.
-
(2012)
J Clin Oncol
, vol.30
, Issue.32
, pp. 3924-3931
-
-
Burnett, A.K.1
Russell, N.H.2
Hills, R.K.3
-
77
-
-
84860176499
-
Fractionated Doses of Gemtuzumab Ozogamicin (GO) Combined to Standard Chemotherapy (CT) Improve Event-Free and Overall Survival in Newly-Diagnosed De Novo AML Patients Aged 50-70 Years Old: A Prospective Randomized Phase 3 Trial From the Acute Leukemia French Association (ALFA)
-
Castaigne S, Pautas C, Terre C, et al. Fractionated Doses of Gemtuzumab Ozogamicin (GO) Combined to Standard Chemotherapy (CT) Improve Event-Free and Overall Survival in Newly-Diagnosed De Novo AML Patients Aged 50-70 Years Old: A Prospective Randomized Phase 3 Trial From the Acute Leukemia French Association (ALFA). ASH Annu Meet Abstr. 2011;118(21):6.
-
(2011)
ASH Annu Meet Abstr
, vol.118
, Issue.21
, pp. 6
-
-
Castaigne, S.1
Pautas, C.2
Terre, C.3
-
78
-
-
84902502307
-
The Addition Of Gemtuzumab Ozogamicin (GO) To Induction Chemotherapy Reduces Relapse and Improves Survival In Patients Without Adverse Risk Karyotype: Results Of An Individual Patient Meta-Analysis Of The Five Randomised Trials
-
Hills RK, Petersdorf S, Estey EH, et al. The Addition Of Gemtuzumab Ozogamicin (GO) To Induction Chemotherapy Reduces Relapse and Improves Survival In Patients Without Adverse Risk Karyotype: Results Of An Individual Patient Meta-Analysis Of The Five Randomised Trials. Blood. 2013;122(21): 356.
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 356
-
-
Hills, R.K.1
Petersdorf, S.2
Estey, E.H.3
-
79
-
-
84872072793
-
Randomized, phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia
-
Sekeres MA, Lancet JE, Wood BL, et al. Randomized, phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia. Haematologica. 2013;98(1):119- 28.
-
(2013)
Haematologica
, vol.98
, Issue.1
, pp. 119-128
-
-
Sekeres, M.A.1
Lancet, J.E.2
Wood, B.L.3
-
80
-
-
84886825064
-
SGN-CD33A: A novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML
-
Kung SutherlandMS,Walter RB, Jeffrey SC, et al. SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood. 2013;122(8):1455-63.
-
(2013)
Blood
, vol.122
, Issue.8
, pp. 1455-1463
-
-
Kung Sutherland, M.S.1
Walter, R.B.2
Jeffrey, S.C.3
|