Synthesis, biological evaluation and SAR studies of novel bicyclic antitumor platinum(IV) complexes

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 374-388

  Lorenzo, Julia ^b   Delgado, Aida ^a   Montaña, Ángel M ^a   Mesas, Juan M ^c   Alegre, María Teresa ^c   Rodríguez, María Del Carmen ^c   Avilés, Francesc Xavier ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Biological evaluation; Cancer; Cisplatin; Malonatoplatinum complexes; Platinum(IV) complexes; SAR study

Indexed keywords

ANTINEOPLASTIC AGENT; PLATINUM DERIVATIVE; UNCLASSIFIED DRUG; [[(3 AMINOMETHYL 7 OXABICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DICHLORIDODIHYDRO]PLATINUM; [[(3 AMINOMETHYL 7 OXABICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DIHYDROXIDOMALONATO]PLATINUM; [[(3 AMINOMETHYL 7 OXABICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]TETRACHLORIDO]PLATINUM; [[(3 AMINOMETHYLBICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM; [[(3 AMINOMETHYLBICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DIHYDROXIDOMALONATO]PLATINUM; [[(3 AMINOMETHYLBICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]TETRACHLORIDO]PLATINUM; [[(3 AMINOMETHYLBICYCLO[2.2.2]OCT 2 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM; [[(3 AMINOMETHYLBICYCLO[2.2.2]OCT 2 YL)METHYLAMINE]DIHYDROXIDOMALONATO]PLATINUM; [[(3 AMINOMETHYLBICYCLO[2.2.2]OCT 2 YL)METHYLAMINE]TETRACHLORIDO]PLATINUM; [[(4,4 DIMETHYL 9 AMINOMETHYL 3,5 DIOXATRICYCLO[5.2.1.0 2,6 ]DEC 8 YL)METHYLAMINE]DICHLORIDODIHYROXIDO]PLATINUM; [[(4,4 DIMETHYL 9 AMINOMETHYL 3,5 DIOXATRICYCLO[5.2.2.0 2,6 ]UNDEX 8 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM; [[(4,4 DIMETHYL 9 AMINOMETHYL 3,5,7 TRIOXATRICYCLO[5.2.1.0 2,6 ]DEC 8 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM; AMINE; LIGAND; PLATINUM COMPLEX; (1,2,3,4,5,6) 5,6 DIHYDROXYBICYCLO[2.2.1]HEPTANE 2,3 DICARBONIRTILE; 7 OXABICYCLO[2.2.1]HEPT 5 EN 2,3 DICARBONITRILE; BICYCLO[2.2.1]HEPT 5 EN 2,3 DICARBONITRILE; BICYCLO[2.2.2]OCT 5 ENE 2,3 DICARBONITRILE; DIPOTASSIUM TRANSDIHYDROXIDOTETRACHLORIDOPLATINATE(IV); [[(3 AMINOMETHYL 7 OXABICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM(IV); [[(3 AMINOMETHYL 7 OXABICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DIHYDROXIDOMALONATO]PLATINUM(IV); [[(3 AMINOMETHYL 7 OXABICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]TETRACHLORIDO]PLATINUM(IV); [[(3 AMINOMETHYLBICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM(IV); [[(3 AMINOMETHYLBICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]DIHYDROXIDOMALONATO]PLATINUM(IV); [[(3 AMINOMETHYLBICYCLO[2.2.1]HEPT 2 YL)METHYLAMINE]TETRACHLORIDO]PLATINUM(IV); [[(3 AMINOMETHYLBICYCLO[2.2.2]OCT 2 YL)METHYLAMINE]DICHLORIDODIHYDROXIDO]PLATINUM(IV); [[(3 AMINOMETHYLBICYCLO[2.2.2]OCT 2 YL)METHYLAMINE]DIHYDROXIDOMALONATO]PLATINUM(IV); [[(3 AMINOMETHYLBICYCLO[2.2.2]OCT 2 YL)METHYLAMINE]TETRACHLORIDO]PLATINUM(IV);

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CATALYST; CELL GROWTH; CELL PH; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG HYDROLYSIS; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HL 60 CELL LINE; HYDROPHILICITY; IC 50; IONIZATION; LIPOPHILICITY; MEMBRANE TRANSPORT; PH; SOLVATION; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; BIOAVAILABILITY; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; HUMAN; SYNTHESIS; CYTOTOXICITY; HUMAN CELL;

AMINES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL AVAILABILITY; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; LIGANDS; ORGANOPLATINUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903599790     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.042     Document Type: Article

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