Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands

Journal of Medicinal Chemistry

Volumn 51, Issue 3, 2008, Pages 424-431

  De Mier Vinué, Jordi ^a   Gay, Marina ^a   Montaña, Ángel M ^a   Sáez, Rosa Isabel ^a   Moreno, Virtudes ^a   Kasparkova, Jana ^b   Vrana, Oldrich ^b   Heringova, Pavla ^b   Brabec, Viktor ^b   Boccarelli, Angela ^c   Coluccia, Mauro ^c   Natile, Giovanni ^c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS(AMINOMETHYL)CARBOBICYCLIC DERIVATIVE; BICYCLO COMPOUND; CISPLATIN; DNA; GLUTATHIONE; PLATINUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOPHYSICS; CANCER CELL CULTURE; CANCER RESISTANCE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA CROSS LINKING; DNA DENATURATION; DNA REPLICATION; DNA SUPERCOILING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG SYNTHESIS; GENE MAPPING; HUMAN; HUMAN CELL; LIGAND BINDING; MELTING POINT; MOLECULAR INTERACTION; OVARY CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS; CELL LINE, TUMOR; CHELATING AGENTS; CISPLATIN; CROSS-LINKING REAGENTS; DIAMINES; DNA; DNA ADDUCTS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLUTATHIONE; HUMANS; KINETICS; LIGANDS; PLATINUM; TRANSITION TEMPERATURE;

EID: 39149099486     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070844u     Document Type: Article

References (23)

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