Disruption of chaperone-mediated autophagydependent degradation of MEF2A by oxidative stress-induced lysosome destabilization

Autophagy

Volumn 10, Issue 6, 2014, Pages 1015-1035

  Zhang, Li ^a,b   Sun, Yang ^b   Fei, Mingjian ^c   Tan, Cheng ^a   Wu, Jing ^a   Zheng, Jie ^d   Tang, Jiqing ^e   Sun, Wei ^e   Lv, Zhaoliang ^e   Bao, Jiandong ^a   Xu, Qiang ^b   Yu, Huixin ^a  

^a JIANGSU INSTITUTE OF NUCLEAR MEDICINE   (China)

^b NANJING UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JIANGNAN UNIVERSITY   (China)

^e CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Chaperone mediated autophagy; Histone deacetylase 4; Myocyte enhancer factor 2A; Neurodegenerative diseases; Oxidative stress

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE DEACETYLASE 4; HYDROGEN PEROXIDE; MYOCYTE ENHANCER FACTOR 2; PROTEIN KINASE; SERINE PROTEINASE; CHAPERONE; HDAC4 PROTEIN, HUMAN; HDAC5 PROTEIN, MOUSE; HISTONE DEACETYLASE; MEF2A PROTEIN, HUMAN; MEF2A PROTEIN, MOUSE; REPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CHAPERONE-MEDIATED AUTOPHAGY; DNA BINDING; HUMAN; HUMAN CELL; LYSOSOME; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN FUNCTION; REPRESSOR GENE; ANIMAL; AUTOPHAGY; BIOLOGICAL MODEL; CELL LINE; GENETICS; HEK293 CELL LINE; METABOLISM; MOUSE; NERVE CELL; NEURODEGENERATIVE DISEASES; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CELL LINE; HEK293 CELLS; HISTONE DEACETYLASES; HUMANS; LYSOSOMES; MEF2 TRANSCRIPTION FACTORS; MICE; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; NEURODEGENERATIVE DISEASES; NEURONS; OXIDATIVE STRESS; PROTEOLYSIS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 84903590343     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.28477     Document Type: Article

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