-
1
-
-
0030895783
-
The gamma-hydroxybutyrate signalling system in brain: Organization and functional implications
-
DOI 10.1016/S0301-0082(96)00064-0, PII S0301008296000640
-
Maitre M. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol. 1997;51:337-61. (Pubitemid 27143802)
-
(1997)
Progress in Neurobiology
, vol.51
, Issue.3
, pp. 337-361
-
-
Maitre, M.1
-
2
-
-
4644323282
-
Fatalities associated with the use of gamma-hydroxybutyrate and its analogues in Australasia
-
Caldicott DG, Chow FY, Burns BJ, Felgate PD, Byard RW. Fatalities associated with the use of gamma-hydroxybutyrate and its analogues in Australasia. Med J Aust. 2004;181:310-3. (Pubitemid 39302713)
-
(2004)
Medical Journal of Australia
, vol.181
, Issue.6
, pp. 310-313
-
-
Caldicott, D.G.E.1
Chow, F.Y.2
Burns, B.J.3
Felgate, P.D.4
Byard, R.W.5
-
3
-
-
79951909577
-
Case series of 226 gamma-hydroxybutyrate-associated deaths: Lethal toxicity and trauma
-
Zvosec DL, Smith SW, Porrata T, Strobl AQ, Dyer JE. Case series of 226 gamma-hydroxybutyrate-associated deaths: lethal toxicity and trauma. Am J Emerg Med. 2011;29:319-32.
-
(2011)
Am J Emerg Med
, vol.29
, pp. 319-332
-
-
Zvosec, D.L.1
Smith, S.W.2
Porrata, T.3
Strobl, A.Q.4
Dyer, J.E.5
-
4
-
-
6344259978
-
Gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL): Analysis of overdose cases reported to the Swiss Toxicological Information Centre
-
Liechti ME, Kupferschmidt H. Gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL): analysis of overdose cases reported to the Swiss Toxicological Information Centre. Swiss Med Wkly. 2004;134:534-7. (Pubitemid 39389966)
-
(2004)
Swiss Medical Weekly
, vol.134
, Issue.35-36
, pp. 534-537
-
-
Liechti, M.E.1
Kupferschmidt, H.2
-
5
-
-
33745955759
-
Transport of gamma-hydroxybutyrate in rat kidney membrane vesicles: Role of monocarboxylate transporters
-
DOI 10.1124/jpet.106.105965
-
Wang Q, Darling IM, Morris ME. Transport of gammahydroxybutyrate in rat kidney membrane vesicles: role of monocarboxylate transporters. J Pharmacol Exp Ther. 2006;318:751-61. (Pubitemid 44061250)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.318
, Issue.2
, pp. 751-761
-
-
Wang, Q.1
Darling, I.M.2
Morris, M.E.3
-
6
-
-
34547218143
-
The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells
-
DOI 10.1124/dmd.107.014852
-
Wang Q, Morris ME. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metab Dispos. 2007;35:1393-9. (Pubitemid 47121781)
-
(2007)
Drug Metabolism and Disposition
, vol.35
, Issue.8
, pp. 1393-1399
-
-
Wang, Q.1
Morris, M.E.2
-
7
-
-
19444362090
-
Renal clearance of gammahydroxybutyric acid in rats: Increasing renal elimination as a detoxification strategy
-
Morris ME, Hu K, Wang Q. Renal clearance of gammahydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy. J Pharmacol Exp Ther. 2005;313:1194- 202.
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 1194-1202
-
-
Morris, M.E.1
Hu, K.2
Wang, Q.3
-
8
-
-
0018372970
-
Dose-dependent pharmacokinetics and hypnotic effects of sodium gamma-hydroxybutyrate in the rat
-
Lettieri JT, Fung HL. Dose-dependent pharmacokinetics and hypnotic effects of sodium gamma-hydroxybutyrate in the rat. J Pharmacol Exp Ther. 1979;208:7-11. (Pubitemid 9154069)
-
(1979)
Journal of Pharmacology and Experimental Therapeutics
, vol.208
, Issue.1
, pp. 7-11
-
-
Lettieri, J.T.1
Fung, H.-L.2
-
9
-
-
0027364308
-
Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers
-
Palatini P, Tedeschi L, Frison G, Padrini R, Zordan R, Orlando R, et al. Dose-dependent absorption and elimination of gammahydroxybutyric acid in healthy volunteers. Eur J Clin Pharmacol. 1993;45:353-6. (Pubitemid 23338545)
-
(1993)
European Journal of Clinical Pharmacology
, vol.45
, Issue.4
, pp. 353-356
-
-
Palatini, P.1
Tedeschi, L.2
Frison, G.3
Padrini, R.4
Zordan, R.5
Orlando, R.6
Gallimberti, L.7
Gessa, G.L.8
Ferrara, S.D.9
-
10
-
-
4644337779
-
GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier
-
DOI 10.1124/jpet.104.069682
-
Bhattacharya I, Boje KM. GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood- brain barrier. J Pharmacol Exp Ther. 2004;311:92-8. (Pubitemid 39287787)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.311
, Issue.1
, pp. 92-98
-
-
Bhattacharya, I.1
Boje, K.M.K.2
-
11
-
-
84876493261
-
Brain extracellular gamma-hydroxybutyrate concentrations are decreased by L-lactate in rats: Role in the treatment of overdoses
-
Roiko SA, Vijay N, Felmlee MA, Morris ME. Brain extracellular gamma-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses. Pharm Res. 2013;30:1338-48.
-
(2013)
Pharm Res
, vol.30
, pp. 1338-1348
-
-
Roiko, S.A.1
Vijay, N.2
Felmlee, M.A.3
Morris, M.E.4
-
12
-
-
76749149579
-
Monocarboxylate transporter- mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells
-
Lam WK, Felmlee MA, Morris ME. Monocarboxylate transporter- mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells. Drug Metab Dispos. 2010;38:441-7.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 441-447
-
-
Lam, W.K.1
Felmlee, M.A.2
Morris, M.E.3
-
13
-
-
84875447051
-
Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of gammahydroxybutyrate and gamma-butyrolactone
-
Morse BL, Morris ME. Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of gammahydroxybutyrate and gamma-butyrolactone. J Pharmacol Exp Ther. 2013;345:102-10.
-
(2013)
J Pharmacol Exp Ther
, vol.345
, pp. 102-110
-
-
Morse, B.L.1
Morris, M.E.2
-
14
-
-
67649397435
-
The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-mediated uptake and inhibition
-
Cui D, Morris ME. The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition. Drug Metab Dispos. 2009;37:1404-10.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1404-1410
-
-
Cui, D.1
Morris, M.E.2
-
15
-
-
84863936468
-
Monocarboxylate transporter inhibition with osmotic diuresis increases γ-hydroxybutyrate renal elimination in humans: A proof-of-concept study
-
Morris ME, Morse BL, Baciewicz GJ, Tessena MM, Acquisto NM, Hutchinson DJ, et al. Monocarboxylate transporter inhibition with osmotic diuresis increases γ-hydroxybutyrate renal elimination in humans: a proof-of-concept study. J Clin Toxicol. 2011;1:1-4.
-
(2011)
J Clin Toxicol
, vol.1
, pp. 1-4
-
-
Morris, M.E.1
Morse, B.L.2
Baciewicz, G.J.3
Tessena, M.M.4
Acquisto, N.M.5
Hutchinson, D.J.6
-
16
-
-
84863884501
-
gamma-Hydroxybutyrate (GHB)-induced respiratory depression: Combined receptortransporter inhibition therapy for treatment in GHB overdose
-
Morse BL, Vijay N, Morris ME. gamma-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptortransporter inhibition therapy for treatment in GHB overdose. Mol Pharmacol. 2012;82:226-35.
-
(2012)
Mol Pharmacol
, vol.82
, pp. 226-235
-
-
Morse, B.L.1
Vijay, N.2
Morris, M.E.3
-
17
-
-
0029797632
-
Effects of sodium lactate on ventilation and acid-base balance in healthy humans
-
Tappy L, Cayeux MC, Chiolero R. Effects of sodium lactate on ventilation and acid - base balance in healthy humans. Clin Physiol. 1996;16:393-401. (Pubitemid 26318539)
-
(1996)
Clinical Physiology
, vol.16
, Issue.4
, pp. 393-401
-
-
Tappy, L.1
Cayeux, M.-C.2
Chiolero, R.3
-
18
-
-
77955979548
-
Mechanistic toxicokinetic model for gamma-hydroxybutyric acid: Inhibition of active renal reabsorption as a potential therapeutic strategy
-
Felmlee MA, Wang Q, Cui D, Roiko SA, Morris ME. Mechanistic toxicokinetic model for gamma-hydroxybutyric acid: inhibition of active renal reabsorption as a potential therapeutic strategy. AAPS J. 2010;12:407-16.
-
(2010)
AAPS J
, vol.12
, pp. 407-416
-
-
Felmlee, M.A.1
Wang, Q.2
Cui, D.3
Roiko, S.A.4
Morris, M.E.5
-
19
-
-
33847134473
-
Pharmacokinetics and pharmacodynamics of gamma-hydroxybutyric acid during tolerance in rats: Effects on extracellular dopamine
-
Raybon JJ, Boje KM. Pharmacokinetics and pharmacodynamics of gamma-hydroxybutyric acid during tolerance in rats: effects on extracellular dopamine. J Pharmacol Exp Ther. 2007;320:1252- 60.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 1252-1260
-
-
Raybon, J.J.1
Boje, K.M.2
-
21
-
-
0029670749
-
gamma-Butyrolactoneinduced absence-like seizures increase nuclear CRE- and AP-1 DNA-binding activities in mouse brain
-
Ishige K, Aizawa M, Ito Y, Fukuda H. gamma-Butyrolactoneinduced absence-like seizures increase nuclear CRE- and AP-1 DNA-binding activities in mouse brain. Neuropharmacology. 1996;35:45-55.
-
(1996)
Neuropharmacology
, vol.35
, pp. 45-55
-
-
Ishige, K.1
Aizawa, M.2
Ito, Y.3
Fukuda, H.4
-
22
-
-
84455174556
-
Brain uptake of the drug of abuse gamma-hydroxybutyric acid in rats
-
Roiko SA, Felmlee MA, Morris ME. Brain uptake of the drug of abuse gamma-hydroxybutyric acid in rats. Drug Metab Dispos. 2012;40:212-8.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 212-218
-
-
Roiko, S.A.1
Felmlee, M.A.2
Morris, M.E.3
-
23
-
-
0029117415
-
Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids
-
Tamai I, Takanaga H, Maeda H, Sai Y, Ogihara T, Higashida H, et al. Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem Biophys Res Commun. 1995;214:482-9.
-
(1995)
Biochem Biophys Res Commun
, vol.214
, pp. 482-489
-
-
Tamai, I.1
Takanaga, H.2
Maeda, H.3
Sai, Y.4
Ogihara, T.5
Higashida, H.6
-
24
-
-
51249118120
-
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
-
Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, et al. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10:193-9.
-
(2008)
AAPS J
, vol.10
, pp. 193-199
-
-
Ganapathy, V.1
Thangaraju, M.2
Gopal, E.3
Martin, P.M.4
Itagaki, S.5
Miyauchi, S.6
-
25
-
-
54049157907
-
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice
-
Frank H, Groger N, Diener M, Becker C, Braun T, Boettger T. Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem. 2008;283:24729-37.
-
(2008)
J Biol Chem
, vol.283
, pp. 24729-24737
-
-
Frank, H.1
Groger, N.2
Diener, M.3
Becker, C.4
Braun, T.5
Boettger, T.6
-
26
-
-
84885852231
-
Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells
-
Draoui N, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, et al . Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013;21:7107-17.
-
(2013)
Bioorg Med Chem
, vol.21
, pp. 7107-7117
-
-
Draoui, N.1
Schicke, O.2
Fernandes, A.3
Drozak, X.4
Nahra, F.5
Dumont, A.6
-
28
-
-
0023750861
-
The kinetics of transport of lactate and pyruvate into rat hepatocytes. Evidence for the presence of a specific carrier similar to that in erythrocytes
-
Edlund GL, Halestrap AP. The kinetics of transport of lactate and pyruvate into rat hepatocytes. Evidence for the presence of a specific carrier similar to that in erythrocytes. Biochem J. 1988;249:117-26.
-
(1988)
Biochem J
, vol.249
, pp. 117-126
-
-
Edlund, G.L.1
Halestrap, A.P.2
-
29
-
-
0022501687
-
Inhibition of lactate removal by ketone bodies in rat liver. Evidence for a quantitatively important role of the plasma membrane lactate transporter in lactate metabolism
-
Metcalfe HK, Monson JP, Welch SG, Cohen RD. Inhibition of lactate removal by ketone bodies in rat liver. Evidence for a quantitatively important role of the plasma membrane lactate transporter in lactate metabolism. J Clin Invest. 1986;78:743-7. (Pubitemid 16024810)
-
(1986)
Journal of Clinical Investigation
, vol.78
, Issue.3
, pp. 743-747
-
-
Metcalfe, H.K.1
Monson, J.P.2
Welch, S.G.3
Cohen, R.D.4
-
30
-
-
84455171517
-
gamma-Hydroxybutyrate blood/plasma partitioning: Effect of physiologic pH on transport by monocarboxylate transporters
-
Morse BL, Felmlee MA, Morris ME. gamma-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters. Drug Metab Dispos. 2012;40:64-9.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 64-69
-
-
Morse, B.L.1
Felmlee, M.A.2
Morris, M.E.3
-
31
-
-
84879415192
-
Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position
-
Kalvass JC, Polli JW, Bourdet DL, Feng B, Huang SM, Liu X, et al. Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clin Pharmacol Ther. 2013;94:80-94.
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 80-94
-
-
Kalvass, J.C.1
Polli, J.W.2
Bourdet, D.L.3
Feng, B.4
Huang, S.M.5
Liu, X.6
-
32
-
-
77952386385
-
Concentrationeffect relationships for the drug of abuse gamma-hydroxybutyric acid
-
Felmlee MA, Roiko SA, Morse BL, Morris ME. Concentrationeffect relationships for the drug of abuse gamma-hydroxybutyric acid. J Pharmacol Exp Ther. 2010;333:761-71. Drug Abuse
-
(2010)
J Pharmacol Exp Ther
, vol.333
, pp. 761-771
-
-
Felmlee, M.A.1
Roiko, S.A.2
Morse, B.L.3
Morris, M.E.4
|