Mechanistic toxicokinetic model for γ-hydroxybutyric acid: Inhibition of active renal reabsorption as a potential therapeutic strategy

AAPS Journal

Volumn 12, Issue 3, 2010, Pages 407-416

  Felmlee, Melanie A ^a   Wang, Qi ^a,b   Cui, Dapeng ^a,c   Roiko, Samuel A ^a   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

^c ICON Development Solutions   (United States)

Author keywords

gamma hydroxybutyrate; kidney reabsorption; pharmacokinetic model; renal clearance; toxicokinetics

Indexed keywords

4 HYDROXYBUTYRIC ACID; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER; 4-HYDROXYBUTYRIC ACID; HYDROXYBUTYRIC ACID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; RAT; SIMULATION; SOLID PHASE EXTRACTION; TOXICOKINETICS; ANIMAL; BLOOD; DRUG EFFECTS; KIDNEY; METABOLISM; SPRAGUE DAWLEY RAT; TOXICITY; URINE;

ANIMALS; AREA UNDER CURVE; HYDROXYBUTYRATES; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77955979548     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9197-x     Document Type: Article

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