Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia

European Archives of Psychiatry and Clinical Neuroscience

Volumn 264, Issue 4, 2014, Pages 357-362

  Williams, Matthew ^a   Pearce, Ronald K B ^a   Hirsch, Steven R ^a   Ansorge, Olaf ^b   Thom, Maria ^c   Maier, Michael ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Astrocytes; Cingulate; Neuropathology; Schizophrenia

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ADULT; AGED; ARTICLE; ASTROCYTE; BIPOLAR DISORDER; CELL DENSITY; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; ICD-10; IMMUNOHISTOCHEMISTRY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MORPHOMETRICS; PRIORITY JOURNAL; RELATIVE DENSITY; SCHIZOPHRENIA; WHITE MATTER; ADOLESCENT; CELL COUNT; METABOLISM; MIDDLE AGED; MOOD DISORDER; PATHOLOGY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASTROCYTES; CELL COUNT; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GYRUS CINGULI; HUMANS; MALE; MIDDLE AGED; MOOD DISORDERS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84903556154     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-013-0482-4     Document Type: Article

References (32)

1. Baquet ZC, Williams D, Brody J, Smeyne RJ (2009) A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse. Neuroscience 161:1082-1090
2. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD (2002) Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry 51:342-344 (Pubitemid 34215000)
3. Bouras C, Kövari E, Hof PR, Riederer BM, Giannakopoulos P (2001) Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol (Berl) 102:373-379 (Pubitemid 32894708)
4. Bradesi S, Golovatscka V, Ennes HS, McRoberts JA, Karagiannides I, Bakirtzi K, Pothoulakis C, Mayer EA (2011) Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol 301:580-589
5. Bush G, Vogt BA, Holmes J, Dale AM, Greve D, Rosen LA (2002) Dorsal anterior cingulate cortex: a role in reward-based decision making. Proc Natl Acad Sci USA 99:523-528 (Pubitemid 34060394)
6. Carter CS, MacDonald AM, Botvinick M, Ross LL, Stenger VA, Noll D, Cohen JD (2000) Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex. Proc Natl Acad Sci USA 97:1944-1948 (Pubitemid 30118548)
7. Carter CS, Mintun M, Nichols T, Cohen JD (1997) Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance. Am J Psychiatry 154:1670-1675 (Pubitemid 27516582)
8. Cotter D, Mackay D, Landau S, Kerwin R, Everall I (2001) Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 58:545-553 (Pubitemid 32523734)
9. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1-105
10. Devinsky O, Morrell MJ, Vogt BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118:279-306
11. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386:824-827 (Pubitemid 27181254)
12. Eastwood SL, Harrison PJ (2001) Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Res Bull 55:569-578 (Pubitemid 32888375)
13. Gittins RA, Harrison PJ (2011) A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder. J Affect Disord 133:328-332
14. Haznedar MM, Buchsbaum MS, Luu C, Hazlett EA, Siegel BV Jr, Lohr J, Wu J, Haier RJ, Bunney WE Jr (1997) Decreased anterior cingulate gyrus metabolic rate in schizophrenia. Am J Psychiatry 154:682-684 (Pubitemid 27197604)
15. Heckers S, Heinsen H, Heinsen YC, Beckmann H (1990) Limbic structures and lateral ventricle in schizophrenia. A quantitative postmortem study. Arch Gen Psychiatry 47:1016-1022 (Pubitemid 20377511)
16. Kasper BS, Taylor DC, Janz D, Kasper EM, Maier M, Williams MR, Crow TJ (2010) Neuropathology of epilepsy and psychosis: the contributions of J.A.N. Corsellis. Brain 133:3795-3805
17. Katsel P, Byne W, Roussos P, Tan W, Siever L, Haroutunian V (2011) Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia. Neuropsychopharmacology 36:1171-1177
18. Kubicki M, Westin CF, Nestor PG, Wible CG, Frumin M, Maier SE, Kikinis R, Jolesz FA, McCarley RW, Shenton ME (2003) Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biol Psychiatry 54:1171-1180 (Pubitemid 37474111)
19. Maragakis NJ, Rothstein JD (2004) Glutamate transporters: animal models to neurologic disease. Neurobiol Dis 15:461-473 (Pubitemid 38429961)
20. Nicholson KJ, Gilliland TM, Winkelstein BA (2013) Upregulation of GLT-1 by treatment with ceftriaxone alleviates radicular pain by reducing spinal astrocyte activation and neuronal hyperexcitability. J Neurosci Res 92:116-129
21. Öngür D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95:13290-13295 (Pubitemid 28509564)
22. Segal D, Schmitz C, Hof PR (2009) Spatial distribution and density of oligodendrocytes in the cingulum bundle are unaltered in schizophrenia. Acta Neuropathol 117:385-394
23. Steffek AE, McCullumsmith RE, Haroutunian V, Meador-Woodruff JH (2008) Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia. Schizophr Res 103:71-82
24. Steiner J, Bernstein HG, Bielau H, Farkas N, Winter J, Dobrowolny H, Brisch R, Gos T, Mawrin C, Myint AM, Bogerts B (2008) S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study. J Psychiatr Res 42:868-876 (Pubitemid 351787739)
25. Todtenkopf MS, Vincent SL, Benes FM (2005) A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain. Schizophr Res 73:79-89 (Pubitemid 39574682)
26. von Bartheld C (2002) Counting particles in tissue sections: choices of methods and importance of calibration to minimize biases. Histol Histopathol 17:639-648
27. Wang F, Sun Z, Cui L, Du X, Wang X, Zhang H, Cong Z, Hong N, Zhang D (2004) Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. Am J Psychiatry 161:573-575 (Pubitemid 38326117)
28. Webster MJ, O'Grady J, Kleinman JE, Weickert CS (2005) Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 133:453-461 (Pubitemid 40726212)
29. Williams MR, Chaudhry R, Perera S, Pearce RKB, Hirsch SR, Ansorge O, Thom M, Maier M (2013) Changes in cortical thickness in the frontal lobes in schizophrenia are a result of thinning of pyramidal cell layers. Eur Arch Psychiatry Clin Neurosci 263:25-39
30. Williams MR, Hampton T, Pearce RKB, Hirsch SR, Ansorge O, Thom M, Maier M (2013) Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia. Eur Arch Psychiatry Clin Neurosci 263:41-52
31. Williams MR, Marsh R, MacDonald CD, Jain J, Pearce RKB, Hirsch SR, Ansorge O, Gentleman SM, Maier M (2013) Neuropathological changes in the nucleus basalis in schizophrenia. Eur Arch Psychiatry Clin Neurosci 263:485-495
32. Yucel M, Pantelis C, Stuart GW, Wood SJ, Maruff P, Velakoulis D, Pipingas A, Crowe SF, Tochon-Danguy HJ, Egan GF (2002) Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophrenia. Am J Psychiatry 159:251-254 (Pubitemid 34126902)