The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo

Diabetologia

Volumn 57, Issue 7, 2014, Pages 1410-1419

  Ittner, Arne A ^a,b   Bertz, Josefine ^a,b   Chan, Tse Yan Becky ^b   Van Eersel, Janet ^a,b   Polly, Patsie ^a   Ittner, Lars M ^a,b,c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b University of Sydney   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

Endoplasmic reticulum; Glucose stimulated insulin secretion; High fat diet; Islet size; Pancreatic islets of Langerhans; Proinsulin; Streptozotocin

Indexed keywords

C PEPTIDE; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN; PROINSULIN; SIL1 PROTEIN; STREPTOZOCIN; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; SIL1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GLUCOSE TOLERANCE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; LIPID DIET; MIN6 CELL LINE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEAT-SHOCK PROTEINS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT;

EID: 84903552187     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3230-z     Document Type: Article

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