메뉴 건너뛰기




Volumn 592, Issue 13, 2014, Pages 2881-2897

Muscle-specific kinase (MuSK) autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; AUTOANTIBODY; BETA DYSTROGLYCAN; CHOLINERGIC RECEPTOR; MUSCLE SPECIFIC KINASE AUTOANTIBODIES; PROTEIN TYROSINE KINASE; RAPSYN; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G; MUSCLE PROTEIN; MUSK PROTEIN, MOUSE; PERIPHERAL MEMBRANE PROTEIN 43K;

EID: 84903544751     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.270207     Document Type: Article
Times cited : (29)

References (86)
  • 1
    • 0033569388 scopus 로고    scopus 로고
    • Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo
    • Akaaboune M, Culican SM, Turney SG & Lichtman JW (1999). Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science 286, 503-507.
    • (1999) Science , vol.286 , pp. 503-507
    • Akaaboune, M.1    Culican, S.M.2    Turney, S.G.3    Lichtman, J.W.4
  • 2
    • 0037071873 scopus 로고    scopus 로고
    • Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands
    • Akaaboune M, Grady RM, Turney S, Sanes JR & Lichtman JW (2002). Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands. Neuron 34, 865-876.
    • (2002) Neuron , vol.34 , pp. 865-876
    • Akaaboune, M.1    Grady, R.M.2    Turney, S.3    Sanes, J.R.4    Lichtman, J.W.5
  • 3
    • 0029155684 scopus 로고
    • Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex
    • Apel ED, Roberds SL, Campbell KP & Merlie JP (1995). Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex. Neuron 15, 115-126.
    • (1995) Neuron , vol.15 , pp. 115-126
    • Apel, E.D.1    Roberds, S.L.2    Campbell, K.P.3    Merlie, J.P.4
  • 4
    • 57649234553 scopus 로고    scopus 로고
    • An ankyrin-based mechanism for functional organization of dytrophin and dystroglycan
    • Ayalon G, Davis JQ, Scotland PB & Bennett V (2008). An ankyrin-based mechanism for functional organization of dytrophin and dystroglycan. Cell 135, 1189-1200.
    • (2008) Cell , vol.135 , pp. 1189-1200
    • Ayalon, G.1    Davis, J.Q.2    Scotland, P.B.3    Bennett, V.4
  • 5
    • 0035816717 scopus 로고    scopus 로고
    • Interactions of the rapsyn RING-H2 domain with dystroglycan
    • Bartoli M, Ramarao MK & Cohen JB (2001). Interactions of the rapsyn RING-H2 domain with dystroglycan. J Biol Chem 276, 24911-24917.
    • (2001) J Biol Chem , vol.276 , pp. 24911-24917
    • Bartoli, M.1    Ramarao, M.K.2    Cohen, J.B.3
  • 6
    • 77954252168 scopus 로고    scopus 로고
    • The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization
    • Bergamin E, Hallock PT, Burden SJ & Hubbard SR (2010). The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell 39, 100-109.
    • (2010) Mol Cell , vol.39 , pp. 100-109
    • Bergamin, E.1    Hallock, P.T.2    Burden, S.J.3    Hubbard, S.R.4
  • 7
    • 0031866190 scopus 로고    scopus 로고
    • The zinc finger domain of the 43-kDa receptor-associated protein, rapsyn: role in acetylcholine receptor clustering
    • Bezakova G & Bloch RJ (1998). The zinc finger domain of the 43-kDa receptor-associated protein, rapsyn: role in acetylcholine receptor clustering. Mol Cell Neurosci 11, 274-288.
    • (1998) Mol Cell Neurosci , vol.11 , pp. 274-288
    • Bezakova, G.1    Bloch, R.J.2
  • 8
    • 7944223078 scopus 로고    scopus 로고
    • Structure and regulation of Src family kinases
    • Boggon TJ & Eck MJ (2004). Structure and regulation of Src family kinases. Oncogene 23, 7918-7927.
    • (2004) Oncogene , vol.23 , pp. 7918-7927
    • Boggon, T.J.1    Eck, M.J.2
  • 9
    • 0035795420 scopus 로고    scopus 로고
    • Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering
    • Borges LS & Ferns M (2001). Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering. J Cell Biol 153, 1-11.
    • (2001) J Cell Biol , vol.153 , pp. 1-11
    • Borges, L.S.1    Ferns, M.2
  • 10
    • 58149264817 scopus 로고    scopus 로고
    • Identification of a motif in the acetylcholine receptor β subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization
    • Borges LS, Yechikov S, Lee YI, Rudell JB, Friese MB, Burden SJ & Ferns MJ (2008). Identification of a motif in the acetylcholine receptor β subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization. J Neurosci 28, 11468-11476.
    • (2008) J Neurosci , vol.28 , pp. 11468-11476
    • Borges, L.S.1    Yechikov, S.2    Lee, Y.I.3    Rudell, J.B.4    Friese, M.B.5    Burden, S.J.6    Ferns, M.J.7
  • 11
    • 27344454636 scopus 로고    scopus 로고
    • Identification of nicotinic acetylcholine receptor recycling and its role in maintaining receptor density at the neuromuscular junction in vivo
    • Bruneau E, Sutter D, Hume RI & Akaaboune M (2005). Identification of nicotinic acetylcholine receptor recycling and its role in maintaining receptor density at the neuromuscular junction in vivo. J Neurosci 25, 9949-9959.
    • (2005) J Neurosci , vol.25 , pp. 9949-9959
    • Bruneau, E.1    Sutter, D.2    Hume, R.I.3    Akaaboune, M.4
  • 12
    • 33845881670 scopus 로고    scopus 로고
    • The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo
    • Bruneau EG & Akaaboune M (2006). The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo. Development 133, 4485-4493.
    • (2006) Development , vol.133 , pp. 4485-4493
    • Bruneau, E.G.1    Akaaboune, M.2
  • 13
    • 0032079525 scopus 로고    scopus 로고
    • Evidence for in situ and in vitro association between β-dystroglycan and the subsynaptic 43K rapsyn protein
    • Cartaud A, Coutant S, Petrucci TC & Cartaud J (1998). Evidence for in situ and in vitro association between β-dystroglycan and the subsynaptic 43K rapsyn protein. J Biol Chem 273, 11321-11326.
    • (1998) J Biol Chem , vol.273 , pp. 11321-11326
    • Cartaud, A.1    Coutant, S.2    Petrucci, T.C.3    Cartaud, J.4
  • 14
    • 84879766930 scopus 로고    scopus 로고
    • Sequence of age-associated changes to the mouse neuromuscular junction and the protective effects of voluntary exercise
    • Cheng A, Morsch M, Murata Y, Ghazanfari N, Reddel SW & Phillips WD (2013). Sequence of age-associated changes to the mouse neuromuscular junction and the protective effects of voluntary exercise. PLoS One 8, e67970.
    • (2013) PLoS One , vol.8
    • Cheng, A.1    Morsch, M.2    Murata, Y.3    Ghazanfari, N.4    Reddel, S.W.5    Phillips, W.D.6
  • 16
    • 9144229330 scopus 로고    scopus 로고
    • Regulation of nicotinic receptor expression by the ubiquitin-proteosome system
    • Christianson JC & Green WN (2004). Regulation of nicotinic receptor expression by the ubiquitin-proteosome system. EMBO J 23, 4156-4165.
    • (2004) EMBO J , vol.23 , pp. 4156-4165
    • Christianson, J.C.1    Green, W.N.2
  • 17
    • 77956275172 scopus 로고    scopus 로고
    • Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice
    • Cole RN, Ghazanfari N, Ngo ST, Gervasio OL, Reddel SW & Phillips WD (2010). Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice. J Physiol 588, 3217-3229.
    • (2010) J Physiol , vol.588 , pp. 3217-3229
    • Cole, R.N.1    Ghazanfari, N.2    Ngo, S.T.3    Gervasio, O.L.4    Reddel, S.W.5    Phillips, W.D.6
  • 18
    • 46749148845 scopus 로고    scopus 로고
    • Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction
    • Cole RN, Reddel SW, Gervásio OL & Phillips WD (2008). Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction. Ann Neurol 63, 782-789.
    • (2008) Ann Neurol , vol.63 , pp. 782-789
    • Cole, R.N.1    Reddel, S.W.2    Gervásio, O.L.3    Phillips, W.D.4
  • 19
    • 0041710928 scopus 로고    scopus 로고
    • Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses
    • Cote PD, Moukhles H, Lindenbaum M & Carbonetto S (1999). Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses. Nat Genet 23, 338-342.
    • (1999) Nat Genet , vol.23 , pp. 338-342
    • Cote, P.D.1    Moukhles, H.2    Lindenbaum, M.3    Carbonetto, S.4
  • 20
    • 60349123753 scopus 로고    scopus 로고
    • Reporting ethical matters in The Journal of Physiology: standards and advice
    • Drummond GB (2009). Reporting ethical matters in The Journal of Physiology: standards and advice. J Physiol 587, 713-719.
    • (2009) J Physiol , vol.587 , pp. 713-719
    • Drummond, G.B.1
  • 21
    • 0038392756 scopus 로고    scopus 로고
    • Postsynaptic requirements for Abl kinases in assembly of the neuromuscular junction
    • Finn AJ, Feng G & Pendergast AM (2003). Postsynaptic requirements for Abl kinases in assembly of the neuromuscular junction. Nat Neurosci 6, 717-723.
    • (2003) Nat Neurosci , vol.6 , pp. 717-723
    • Finn, A.J.1    Feng, G.2    Pendergast, A.M.3
  • 22
    • 38349078279 scopus 로고    scopus 로고
    • Synaptic differentiation is defective in mice lacking acetylcholine receptor β-subunit tyrosine phosphorylation
    • Friese MB, Blagden CS & Burden SJ (2007). Synaptic differentiation is defective in mice lacking acetylcholine receptor β-subunit tyrosine phosphorylation. Development 134, 4167-4176.
    • (2007) Development , vol.134 , pp. 4167-4176
    • Friese, M.B.1    Blagden, C.S.2    Burden, S.J.3
  • 23
    • 0033179225 scopus 로고    scopus 로고
    • Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors
    • Fuhrer C, Gautam M, Sugiyama JE & Hall ZW (1999). Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors. J Neurosci 19, 6405-6416.
    • (1999) J Neurosci , vol.19 , pp. 6405-6416
    • Fuhrer, C.1    Gautam, M.2    Sugiyama, J.E.3    Hall, Z.W.4
  • 24
    • 0029773535 scopus 로고    scopus 로고
    • Functional interaction of Src family kinases with the acetylcholine receptor in C2 myotubes
    • Fuhrer C & Hall ZW (1996). Functional interaction of Src family kinases with the acetylcholine receptor in C2 myotubes. J Biol Chem 271, 32474-32481.
    • (1996) J Biol Chem , vol.271 , pp. 32474-32481
    • Fuhrer, C.1    Hall, Z.W.2
  • 25
    • 0029050847 scopus 로고
    • Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn deficient mice
    • Gautam M, Noakes PG, Mudd J, Nichol M, Chu GC, Sanes JR & Merlie JP (1995). Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn deficient mice. Nature 377, 232-236.
    • (1995) Nature , vol.377 , pp. 232-236
    • Gautam, M.1    Noakes, P.G.2    Mudd, J.3    Nichol, M.4    Chu, G.C.5    Sanes, J.R.6    Merlie, J.P.7
  • 26
    • 34247149888 scopus 로고    scopus 로고
    • Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability
    • Gervásio OL, Armson PF & Phillips WD (2007). Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability. Dev Biol 305, 262-275.
    • (2007) Dev Biol , vol.305 , pp. 262-275
    • Gervásio, O.L.1    Armson, P.F.2    Phillips, W.D.3
  • 27
    • 13844255640 scopus 로고    scopus 로고
    • Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse
    • Gervásio OL & Phillips WD (2005). Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. J Physiol 562, 673-685.
    • (2005) J Physiol , vol.562 , pp. 673-685
    • Gervásio, O.L.1    Phillips, W.D.2
  • 29
    • 0033757623 scopus 로고    scopus 로고
    • Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin-glycoprotein complex
    • Grady RM, Zhou H, Cunningham JM, Henry MD, Campbell KP & Sanes JR (2000). Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin-glycoprotein complex. Neuron 25, 279-293.
    • (2000) Neuron , vol.25 , pp. 279-293
    • Grady, R.M.1    Zhou, H.2    Cunningham, J.M.3    Henry, M.D.4    Campbell, K.P.5    Sanes, J.R.6
  • 30
    • 79952513213 scopus 로고    scopus 로고
    • Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis
    • Higuchi O, Hamuro J, Motomura M & Yamanashi Y (2011). Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis. Ann Neurol 69, 418-422.
    • (2011) Ann Neurol , vol.69 , pp. 418-422
    • Higuchi, O.1    Hamuro, J.2    Motomura, M.3    Yamanashi, Y.4
  • 31
    • 0035105784 scopus 로고    scopus 로고
    • Autoantibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A & Vincent A (2001). Autoantibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7, 365-368.
    • (2001) Nat Med , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 32
    • 0032513058 scopus 로고    scopus 로고
    • Dimerization of the muscle-specific kinase induces tyrosine phosphorylation of acetylcholine receptors and their aggregation on the surface of myotubes
    • Hopf C & Hoch W (1998). Dimerization of the muscle-specific kinase induces tyrosine phosphorylation of acetylcholine receptors and their aggregation on the surface of myotubes. J Biol Chem 273, 6467-6473.
    • (1998) J Biol Chem , vol.273 , pp. 6467-6473
    • Hopf, C.1    Hoch, W.2
  • 33
    • 0037441504 scopus 로고    scopus 로고
    • Rapsyn-mediated clustering of acetylcholine receptor subunits requires the major cytoplasmic loop of the receptor subunits
    • Huebsch KA & Maimone MM (2003). Rapsyn-mediated clustering of acetylcholine receptor subunits requires the major cytoplasmic loop of the receptor subunits. J Neurobiol 54, 486-501.
    • (2003) J Neurobiol , vol.54 , pp. 486-501
    • Huebsch, K.A.1    Maimone, M.M.2
  • 35
    • 0020960073 scopus 로고
    • Degradation of acteylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties
    • Hyman C & Froehner SC (1983). Degradation of acteylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties. J Cell Biol 95, 1316-1324.
    • (1983) J Cell Biol , vol.95 , pp. 1316-1324
    • Hyman, C.1    Froehner, S.C.2
  • 36
    • 0035809195 scopus 로고    scopus 로고
    • The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane
    • Jacobson C, Cote PD, Rossi SG, Rotundo RL & Carbonetto S (2001). The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane. J Cell Biol 152, 435-450.
    • (2001) J Cell Biol , vol.152 , pp. 435-450
    • Jacobson, C.1    Cote, P.D.2    Rossi, S.G.3    Rotundo, R.L.4    Carbonetto, S.5
  • 37
    • 0037439662 scopus 로고    scopus 로고
    • A role for the juxtamembrane domain of β-dystroglycan in agrin-induced acetylcholine receptor clustering
    • Kahl J & Campanelli JT (2003). A role for the juxtamembrane domain of β-dystroglycan in agrin-induced acetylcholine receptor clustering. J Neurosci 23, 392-402.
    • (2003) J Neurosci , vol.23 , pp. 392-402
    • Kahl, J.1    Campanelli, J.T.2
  • 39
    • 37549039005 scopus 로고    scopus 로고
    • MuSK controls where motor axons grow and form synapses
    • Kim N & Burden SJ (2008). MuSK controls where motor axons grow and form synapses. Nat Neurosci 11, 19-27.
    • (2008) Nat Neurosci , vol.11 , pp. 19-27
    • Kim, N.1    Burden, S.J.2
  • 42
    • 84892393537 scopus 로고    scopus 로고
    • MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-Independent AChR clusters
    • Koneczny I, Cossins J, Waters P, Beeson D & Vincent A (2013). MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-Independent AChR clusters. PLoS One 11, e80695.
    • (2013) PLoS One , vol.11
    • Koneczny, I.1    Cossins, J.2    Waters, P.3    Beeson, D.4    Vincent, A.5
  • 44
    • 68349150906 scopus 로고    scopus 로고
    • Rapsyn interacts with the muscle acetylcholine receptor via α-helical domains in the α, β, and ε subunit intracellular loops
    • Lee Y, Rudell J & Ferns M (2009). Rapsyn interacts with the muscle acetylcholine receptor via α-helical domains in the α, β, and ε subunit intracellular loops. Neuroscience 163, 222-232.
    • (2009) Neuroscience , vol.163 , pp. 222-232
    • Lee, Y.1    Rudell, J.2    Ferns, M.3
  • 45
    • 33847767789 scopus 로고    scopus 로고
    • Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation
    • Lefebvre JL, Juing L, Becaficco S, Franzini-Armstrong C & Granato M (2007). Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Proc Natl Acad Sci U S A 104, 2483-2488.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2483-2488
    • Lefebvre, J.L.1    Juing, L.2    Becaficco, S.3    Franzini-Armstrong, C.4    Granato, M.5
  • 47
    • 34250769508 scopus 로고    scopus 로고
    • Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction
    • Lu Z, Je H-S, Young P, Gross J, Lu B & Feng G (2007). Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J Cell Biol 177, 1077-1089.
    • (2007) J Cell Biol , vol.177 , pp. 1077-1089
    • Lu, Z.1    Je, H.-S.2    Young, P.3    Gross, J.4    Lu, B.5    Feng, G.6
  • 49
    • 0021279277 scopus 로고
    • The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscle
    • McMahan UJ & Slater CR (1984). The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscle. J Cell Biol 98, 1453-1473.
    • (1984) J Cell Biol , vol.98 , pp. 1453-1473
    • McMahan, U.J.1    Slater, C.R.2
  • 51
    • 0035957950 scopus 로고    scopus 로고
    • Agrin-activation of acetylcholine receptor-bound src family kinases requires rapsyn and correlates with acetylcholine receptor clustering
    • Mittaud P, Marangi PA, Erb-Vogtli S & Fuhrer C (2001). Agrin-activation of acetylcholine receptor-bound src family kinases requires rapsyn and correlates with acetylcholine receptor clustering. J Biol Chem 276, 14505-14513.
    • (2001) J Biol Chem , vol.276 , pp. 14505-14513
    • Mittaud, P.1    Marangi, P.A.2    Erb-Vogtli, S.3    Fuhrer, C.4
  • 52
    • 0035370294 scopus 로고    scopus 로고
    • Src-class kinases act within the agrin/MuSK pathway to regulate acetylcholine receptor phosphorylation, cytoskeletal anchoring, and clustering
    • Mohamed AS, Rivas-Plata KA, Kraas JR, Saleh SM & Swope SL (2001). Src-class kinases act within the agrin/MuSK pathway to regulate acetylcholine receptor phosphorylation, cytoskeletal anchoring, and clustering. J Neurosci 21, 3806-3818.
    • (2001) J Neurosci , vol.21 , pp. 3806-3818
    • Mohamed, A.S.1    Rivas-Plata, K.A.2    Kraas, J.R.3    Saleh, S.M.4    Swope, S.L.5
  • 53
    • 0032519864 scopus 로고    scopus 로고
    • Laminin and α-dystroglycan mediate acetylcholine receptor aggregation via a MuSK-independent pathway
    • Montanaro F, Gee SH, Jacobson C, Lindenbaum MH, Froehner SC & Carbonetto S (1998). Laminin and α-dystroglycan mediate acetylcholine receptor aggregation via a MuSK-independent pathway. J Neurosci 18, 1250-1260.
    • (1998) J Neurosci , vol.18 , pp. 1250-1260
    • Montanaro, F.1    Gee, S.H.2    Jacobson, C.3    Lindenbaum, M.H.4    Froehner, S.C.5    Carbonetto, S.6
  • 54
    • 0037470047 scopus 로고    scopus 로고
    • Agrin regulates rapsyn interaction with surface AChRs which underlies cytoskeletal anchoring and clustering
    • Moransard M, Borges LS, Willmann R, Marangi PA, Brenner HR, Ferns MJ & Fuhrer C (2003). Agrin regulates rapsyn interaction with surface AChRs which underlies cytoskeletal anchoring and clustering. J Biol Chem 278, 7350-7359.
    • (2003) J Biol Chem , vol.278 , pp. 7350-7359
    • Moransard, M.1    Borges, L.S.2    Willmann, R.3    Marangi, P.A.4    Brenner, H.R.5    Ferns, M.J.6    Fuhrer, C.7
  • 56
    • 84857914720 scopus 로고    scopus 로고
    • Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis
    • Mori S, Yamada S, Kubo S, Chen J, Matsuda S, Shudou M, Maruyama N & Shigemoto K (2012b). Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis. J Neuroimmunol 244, 1-7.
    • (2012) J Neuroimmunol , vol.244 , pp. 1-7
    • Mori, S.1    Yamada, S.2    Kubo, S.3    Chen, J.4    Matsuda, S.5    Shudou, M.6    Maruyama, N.7    Shigemoto, K.8
  • 57
    • 84864818526 scopus 로고    scopus 로고
    • Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors
    • Morsch M, Reddel SW, Ghazanfari N, Toyka KV & Phillips WD (2012). Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors. Exp Neurol 237, 286-295.
    • (2012) Exp Neurol , vol.237 , pp. 286-295
    • Morsch, M.1    Reddel, S.W.2    Ghazanfari, N.3    Toyka, K.V.4    Phillips, W.D.5
  • 58
    • 84877828612 scopus 로고    scopus 로고
    • Pyridostigmine but not 3,4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle-specific kinase autoantibody
    • Morsch M, Reddel SW, Ghazanfari N, Toyka KV & Phillips WD (2013). Pyridostigmine but not 3, 4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle-specific kinase autoantibody. J Physiol 591, 2747-2762.
    • (2013) J Physiol , vol.591 , pp. 2747-2762
    • Morsch, M.1    Reddel, S.W.2    Ghazanfari, N.3    Toyka, K.V.4    Phillips, W.D.5
  • 59
    • 84861216868 scopus 로고    scopus 로고
    • Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering via muscle-specific kinase phosphorylation
    • Ngo ST, Cole RN, Sunn N, Phillips WD & Noakes PG (2012). Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering via muscle-specific kinase phosphorylation. J Cell Sci 125, 1531-1543.
    • (2012) J Cell Sci , vol.125 , pp. 1531-1543
    • Ngo, S.T.1    Cole, R.N.2    Sunn, N.3    Phillips, W.D.4    Noakes, P.G.5
  • 61
    • 84905008931 scopus 로고    scopus 로고
    • Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis
    • DOI: 10.1007/s12031-013-0170-x.
    • Ohno K, Ito M, Kawakami Y & Ohtsuka K (2013). Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis. J Mol Neurosci DOI: 10.1007/s12031-013-0170-x.
    • (2013) J Mol Neurosci
    • Ohno, K.1    Ito, M.2    Kawakami, Y.3    Ohtsuka, K.4
  • 63
    • 0021986426 scopus 로고
    • Association of the postsynaptic 43K protein with newly formed acetylcholine receptor clusters in cultured muscle cells
    • Peng HB & Froehner SC (1985). Association of the postsynaptic 43K protein with newly formed acetylcholine receptor clusters in cultured muscle cells. J Cell Biol 100, 1698-1705.
    • (1985) J Cell Biol , vol.100 , pp. 1698-1705
    • Peng, H.B.1    Froehner, S.C.2
  • 65
    • 0027368111 scopus 로고
    • Clustering and immobilization of acetylcholine receptors by the 43-kD protein: a role for dystrophin-related protein
    • Phillips WD, Noakes PG, Roberds SL, Campbell KP & Merlie JP (1993). Clustering and immobilization of acetylcholine receptors by the 43-kD protein: a role for dystrophin-related protein. J Cell Biol 123, 729-740.
    • (1993) J Cell Biol , vol.123 , pp. 729-740
    • Phillips, W.D.1    Noakes, P.G.2    Roberds, S.L.3    Campbell, K.P.4    Merlie, J.P.5
  • 67
    • 0023125948 scopus 로고
    • Disruption and reformation of the acetylcholine receptor clusters of cultured rat myotubes occur in two distinct stages
    • Pumplin DW & Bloch RJ (1987). Disruption and reformation of the acetylcholine receptor clusters of cultured rat myotubes occur in two distinct stages. J Cell Biol 104, 97-108.
    • (1987) J Cell Biol , vol.104 , pp. 97-108
    • Pumplin, D.W.1    Bloch, R.J.2
  • 68
    • 79958743273 scopus 로고    scopus 로고
    • Muscle-selective synaptic disassembly and reorganization in MuSK antibody-positive MG mice
    • Punga AR, Lin S, Oliveri F, Meinen S & Ruegg MA (2011). Muscle-selective synaptic disassembly and reorganization in MuSK antibody-positive MG mice. Exp Neurol 230, 207-217.
    • (2011) Exp Neurol , vol.230 , pp. 207-217
    • Punga, A.R.1    Lin, S.2    Oliveri, F.3    Meinen, S.4    Ruegg, M.A.5
  • 69
    • 0035831437 scopus 로고    scopus 로고
    • Role of rapsyn tetratrico repeat and coiled-coil domains in self association and nicotinic acetylcholine receptor clustering
    • Ramarao MK, Bianchetta MJ, Lanken J & Cohen JB (2001). Role of rapsyn tetratrico repeat and coiled-coil domains in self association and nicotinic acetylcholine receptor clustering. J Biol Chem 276, 7475-7483.
    • (2001) J Biol Chem , vol.276 , pp. 7475-7483
    • Ramarao, M.K.1    Bianchetta, M.J.2    Lanken, J.3    Cohen, J.B.4
  • 70
    • 0032584213 scopus 로고    scopus 로고
    • Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn
    • Ramarao MK & Cohen JB (1998). Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn. Proc Natl Acad Sci U S A 95, 4007-4012.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4007-4012
    • Ramarao, M.K.1    Cohen, J.B.2
  • 73
    • 27744607526 scopus 로고    scopus 로고
    • Src-family kinases stabilize the neuromuscular synapse via protein interactions, phosphorylation, and cytoskeletal linkage
    • Sadasivam G, Willman R, Lin S, Erb-Vogtli S, Kong XC, Ruegg MA & Fuhrer C (2005). Src-family kinases stabilize the neuromuscular synapse via protein interactions, phosphorylation, and cytoskeletal linkage. J Neurosci 25, 10479-10493.
    • (2005) J Neurosci , vol.25 , pp. 10479-10493
    • Sadasivam, G.1    Willman, R.2    Lin, S.3    Erb-Vogtli, S.4    Kong, X.C.5    Ruegg, M.A.6    Fuhrer, C.7
  • 75
    • 2942620897 scopus 로고    scopus 로고
    • Are MuSK antibodies the primary cause of myasthenic symptoms
    • Selcen D, Fukuda T, Shen X-M & Engel AG (2004). Are MuSK antibodies the primary cause of myasthenic symptoms? Neurology 62, 1945-1950.
    • (2004) Neurology , vol.62 , pp. 1945-1950
    • Selcen, D.1    Fukuda, T.2    Shen, X.-M.3    Engel, A.G.4
  • 80
    • 0030879133 scopus 로고    scopus 로고
    • Laminin-induced acetylcholine receptor clustering: an alternative pathway
    • Sugiyama JE, Glass DJ, Yancopoulos GD & Hall ZW (1997). Laminin-induced acetylcholine receptor clustering: an alternative pathway. J Cell Biol 139, 181-191.
    • (1997) J Cell Biol , vol.139 , pp. 181-191
    • Sugiyama, J.E.1    Glass, D.J.2    Yancopoulos, G.D.3    Hall, Z.W.4
  • 82
    • 84858155813 scopus 로고    scopus 로고
    • Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects
    • Viegas S, Jacobson L, Waters P, Cossins J, Jacob S, Leite MI, Webster R & Vincent A (2012). Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects. Exp Neurol 234, 506-512.
    • (2012) Exp Neurol , vol.234 , pp. 506-512
    • Viegas, S.1    Jacobson, L.2    Waters, P.3    Cossins, J.4    Jacob, S.5    Leite, M.I.6    Webster, R.7    Vincent, A.8
  • 83
    • 0037458558 scopus 로고    scopus 로고
    • Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells
    • Weston C, Gordon C, Teressa G, Hod E, Ren X-D & Prives J (2003). Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells. J Biol Chem 278, 6450-6455.
    • (2003) J Biol Chem , vol.278 , pp. 6450-6455
    • Weston, C.1    Gordon, C.2    Teressa, G.3    Hod, E.4    Ren, X.-D.5    Prives, J.6
  • 85
    • 39549114805 scopus 로고    scopus 로고
    • Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin
    • Zhu D, Yang Z, Luo Z, Luo S, Xiong WC & Mei L (2008). Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin. J Neurosci 28, 1688-1696.
    • (2008) J Neurosci , vol.28 , pp. 1688-1696
    • Zhu, D.1    Yang, Z.2    Luo, Z.3    Luo, S.4    Xiong, W.C.5    Mei, L.6
  • 86
    • 84879528475 scopus 로고    scopus 로고
    • Structure and superorganization of acetylcholine receptor-rapsyn complexes
    • Zubera B & Unwin N (2013). Structure and superorganization of acetylcholine receptor-rapsyn complexes. Proc Natl Acad Sci U S A 110, 10622-10627.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 10622-10627
    • Zubera, B.1    Unwin, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.