Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

Experimental Neurology

Volumn 234, Issue 2, 2012, Pages 506-512

  Viegas, Stuart ^a   Jacobson, Leslie ^a   Waters, Patrick ^a   Cossins, Judith ^a   Jacob, Saiju ^a   Leite, M Isabel ^a   Webster, Richard ^a   Vincent, Angela ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; CORTICOSTEROID; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; METHOTREXATE; MUSCLE SPECIFIC KINASE; PROTEIN ANTIBODY; RECOMBINANT MUSCLE SPECIFIC KINASE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASE REPORT; CHILD; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GASTROCNEMIUS MUSCLE; HUMAN; MALE; MASSETER MUSCLE; MINIATURE ENDPLATE POTENTIAL; MOUSE; MYASTHENIA GRAVIS; NEUROMUSCULAR FUNCTION; NEUROMUSCULAR SYNAPSE; NEUROMUSCULAR TRANSMISSION; NONHUMAN; PASSIVE IMMUNIZATION; POSTSYNAPTIC POTENTIAL; PRESCHOOL CHILD; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; AUTOANTIBODIES; DISEASE MODELS, ANIMAL; IMMUNIZATION, PASSIVE; MICE; MOTOR ACTIVITY; MUSCLE WEAKNESS; MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL; NEUROMUSCULAR JUNCTION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CHOLINERGIC; SYNAPSES; VACCINATION;

EID: 84858155813     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.01.025     Document Type: Article

References (30)

1. Burges J., Wray D.W., Pizzighella S., Hall Z., Vincent A. A myasthenia gravis plasma immunoglobulin reduces miniature endplate potentials at human endplates in vitro. Muscle Nerve 1990, 13(5):407-413. May.
2. Burges J., Vincent A., Molenaar P.C., Newsom-Davis J., Peers C., Wray D. Passive transfer of seronegative myasthenia gravis to mice. Muscle Nerve 1994, 17(12):1393-1400. Dec.
3. Cole R.N., Reddel S.W., Gervasio O.L., Phillips W.D. Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction. Ann. Neurol. 2008, 63(6):782-789. Jun.
4. Cole R.N., Ghazanfari N., Ngo S.T., Gervasio O.L., Reddel S.W., Phillips W.D. Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice. J. Physiol. 2010, 588(Pt 17):3217-3229. Sep 1.
5. Cossins J., Webster R., Maxwell S., Burke G., Vincent A., Beeson D. A mouse model of AChR deficiency syndrome with a phenotype reflecting the human condition. Hum. Mol. Genet. 2004, 13(23):2947-2957. Dec 1.
6. DeChiara T.M., Bowen D.C., Valenzuela D.M., Simmons M.V., Poueymirou W.T., Thomas S., et al. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell 1996, 85(4):501-512. May 17.
7. Drachman D.B., Angus C.W., Adams R.N., Michelson J.D., Hoffman G.J. Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation. N. Engl. J. Med. 1978, 298(20):1116-1122. May 18.
8. Engel A.G., Lambert E.H., Howard F.M. Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations. Mayo Clin. Proc. 1977, 52(5):267-280. May.
9. Evoli A., Tonali P.A., Padua L., Monaco M.L., Scuderi F., Batocchi A.P., et al. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis. Brain 2003, 126(Pt 10):2304-2311. Oct.
10. Fambrough D.M., Drachman D.B., Satyamurti S. Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors. Science 1973, 182(109):293-295. Oct 19.
11. Farrugia M.E., Kennett R.P., Newsom-Davis J., Hilton-Jones D., Vincent A. Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis. Muscle Nerve 2006, 33(4):568-570. Apr.
12. Hoch W. Molecular dissection of neuromuscular junction formation. Trends Neurosci. 2003, 26(7):335-337. Jul.
13. Hoch W., McConville J., Helms S., Newsom-Davis J., Melms A., Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat. Med. 2001, 7(3):365-368. Mar.
14. Ito Y., Miledi R., Vincent A., Newsom-Davis J. Acetylcholine receptors and end-plate electrophysiology in myasthenia gravis. Brain 1978, 101(2):345-368. Jun.
15. Jermy A., Beeson D., Vincent A. Pathogenic autoimmunity to affinity-purified mouse acetylcholine receptor induced without adjuvant in BALB/c mice. Eur. J. Immunol. 1993, 23(4):973-976. Apr.
16. Jha S., Xu K., Maruta T., Oshima M., Mosier D.R., Atassi M.Z., et al. Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK). J. Neuroimmunol. 2006, 175(1-2):107-117. Jun.
17. Kong X.C., Barzaghi P., Ruegg M.A. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO Rep. 2004, 5(2):183-188. Feb.
18. Leite M.I., Jacob S., Viegas S., Cossins J., Clover L., Morgan B.P., et al. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain 2008, 131(Pt 7):1940-1952. Jul.
19. McConville J., Farrugia M.E., Beeson D., Kishore U., Metcalfe R., Newsom-Davis J., et al. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. Ann. Neurol. 2004, 55(4):580-584. Apr.
20. Niks E.H., Kuks J.B., Wokke J.H., Veldman H., Bakker E., Verschuuren J.J. Pre- and postsynaptic neuromuscular junction abnormalities in MuSK myasthenia. Muscle Nerve 2011, 42(2):283-288. Aug.
21. Patrick J., Lindstrom J. Autoimmune response to acetylcholine receptor. Science 1973, 180(88):871-872. May 25.
22. Plomp J.J., Van Kempen G.T., De Baets M.B., Graus Y.M., Kuks J.B., Molenaar P.C. Acetylcholine release in myasthenia gravis: regulation at single end-plate level. Ann. Neurol. 1995, 37(5):627-636. May.
23. Punga A.R., Lin S., Oliveri F., Meinen S., Ruegg M.A. Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice. Exp. Neurol. 2011, 230(2):207-217. Aug.
24. Rodgaard A., Nielsen F.C., Djurup R., Somnier F., Gammeltoft S. Acetylcholine receptor antibody in myasthenia gravis: predominance of IgG subclasses 1 and 3. Clin. Exp. Immunol. 1987, 67(1):82-88. Jan.
25. Shigemoto K., Kubo S., Maruyama N., Hato N., Yamada H., Jie C., et al. Induction of myasthenia by immunization against muscle-specific kinase. J. Clin. Invest. 2006, 116(4):1016-1024. Apr.
26. Shiraishi H., Motomura M., Yoshimura T., Fukudome T., Fukuda T., Nakao Y., et al. Acetylcholine receptors loss and postsynaptic damage in MuSK antibody-positive myasthenia gravis. Ann. Neurol. 2005, 57(2):289-293. Feb.
27. ter Beek W.P., Martinez-Martinez P., Losen M., de Baets M.H., Wintzen A.R., Verschuuren J.J., et al. The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates. Am. J. Pathol. 2009, 175(4):1536-1544. Oct.
28. Toyka K.V., Brachman D.B., Pestronk A., Kao I. Myasthenia gravis: passive transfer from man to mouse. Science 1975, 190(4212):397-399. Oct 24.
29. Vincent A., Newsom-Davis J. Acetylcholine receptor antibody characteristics in myasthenia gravis. I. Patients with generalized myasthenia or disease restricted to ocular muscles. Clin. Exp. Immunol. 1982, 49(2):257-265. Aug.
30. Wood S.J., Slater C.R. Safety factor at the neuromuscular junction. Prog. Neurobiol. 2001, 64(4):393-429. Jul.