Pre- and postsynaptic neuromuscular junction abnormalities in muSK myasthenia

Muscle and Nerve

Volumn 42, Issue 2, 2010, Pages 283-288

  Niks, Erik H ^a   Kuks, Jan B M ^b   Wokke, John H J ^c   Veldman, Henk ^c   Bakker, Egbert ^a   Verschuuren, Jan J G M ^a   Plomp, Jaap J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Histology; In vitro electrophysiology; Miniature end plate potential; MuSK, myasthenia gravis; Neuromuscular junction; Quantal content

Indexed keywords

ACETYLCHOLINE; ANTIBODY; MUSCLE SPECIFIC KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; DENERVATION; ELECTROPHYSIOLOGY; ENDPLATE POTENTIAL; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MYASTHENIA GRAVIS; NERVE DEGENERATION; NEUROMUSCULAR SYNAPSE; PATHOPHYSIOLOGY; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL;

ADULT; AUTOANTIBODIES; ELECTROPHYSIOLOGY; FEMALE; HUMANS; MOTOR ENDPLATE; MUSCLE WEAKNESS; MUSCLE, SKELETAL; MYASTHENIA GRAVIS; NEUROMUSCULAR JUNCTION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CHOLINERGIC;

EID: 77955155824     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.21642     Document Type: Article

References (25)

1. Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001;7:365-368. (Pubitemid 32224355)
2. Vincent A, Leite MI, Farrugia ME, Jacob S, Viegas S, Shiraishi H, et al. Myasthenia gravis seronegative for acetylcholine receptor antibodies. Ann NY Acad Sci 2008;1132:84-92. (Pubitemid 351841363)
3. DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, et al. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell 1996;85: 501-512. (Pubitemid 26157189)
4. Farrugia ME, Bonifati DM, Clover L, Cossins J, Beeson D, Vincent A. Effect of sera from AChR-antibody negative myasthenia gravis patients on AChR and MuSK in cell cultures. J Neuroimmunol 2007; 185:136-144. (Pubitemid 46497437)
5. Kim N, Stiegler AL, Cameron TO, Hallock PT, Gomez AM, Huang JH, et al. Lrp4 is a receptor for agrin and forms a complex with MuSK. Cell 2008;135:334-342.
6. Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, Mei L. LRP4 serves as a coreceptor of agrin. Neuron 2008;60:285-297.
7. Linnoila J, Wang Y, Yao Y, Wang ZZ. A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction. Neuron 2008;60:625-641.
8. Cartaud A, Strochlic L, Guerra M, Blanchard B, Lambergeon M, Krejci E, et al. MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction. J Cell Biol 2004;165:505-515. (Pubitemid 38679616)
9. Song Y, Balice-Gordon R. New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation. Neuron 2008;60:526-528.
10. Strochlic L, Cartaud A, Cartaud J. The synaptic muscle-specific kinase (MuSK) complex: new partners, new functions. Bioessays 2005; 27:1129-1135. (Pubitemid 43076139)
11. Niks EH, van Leeuwen Y, Leite MI, Dekker FW, Wintzen AR, Wirtz PW, et al. Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1. J Neuroimmunol 2008;195: 151-156.
12. Shiraishi H, Motomura M, Yoshimura T, Fukudome T, Fukuda T, Nakao Y, et al. Acetylcholine receptors loss and postsynaptic damage in MuSK antibody-positive myasthenia gravis. Ann Neurol 2005;57: 289-293. (Pubitemid 40179868)
13. Selcen D, Fukuda T, Shen XM, Engel AG. Are MuSK antibodies the primary cause of myasthenic symptoms? Neurology 2004;62: 1945-1950.
14. Plomp JJ, Van Kempen GT, De Baets MB, Graus YM, Kuks JB, Molenaar PC. Acetylcholine release in myasthenia gravis: regulation at single end-plate level. Ann Neurol 1995;37:627-636.
15. Pestronk A, Drachman DB. A new stain for quantitative measurement of sprouting at neuromuscular junctions. Muscle Nerve 1978;1:70-74.
16. Elmqvist D, Hofmann WW, Kugelberg J, Quastel DM. An electrophysiological investigation of neuromuscular transmission in myasthenia gravis. J Physiol 1964;174:417-434.
17. Cull-Candy SG, Miledi R, Trautmann A, Uchitel OD. On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end-plates. J Physiol 1980;299:621-638. (Pubitemid 10113776)
18. Burges J, Vincent A, Molenaar PC, Newsom-Davis J, Peers C, Wray D. Passive transfer of seronegative myasthenia gravis to mice. Muscle Nerve 1994;17:1393-1400. (Pubitemid 24362811)
19. Shigemoto K, Kubo S, Maruyama N, Hato N, Yamada H, Jie C, et al. Induction of myasthenia by immunization against muscle-specific kinase. J Clin Invest 2006;116:1016-1024.
20. Slater CR, Lyons PR, Walls TJ, Fawcett PR, Young C. Structure and function of neuromuscular junctions in the vastus lateralis of man. A motor point biopsy study of two groups of patients. Brain 1992;115: 451-478.
21. Valenzuela DM, Stitt TN, DiStefano PS, Rojas E, Mattsson K, Compton DL, et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron 1995;15:573-584.
22. Ip FC, Glass DG, Gies DR, Cheung J, Lai KO, Fu AK, et al. Cloning and characterization of muscle-specific kinase in chicken. Mol Cell Neurosci 2000;16:661-673. (Pubitemid 32001313)
23. Maselli RA, Wollman RL, Leung C, Distad B, Palombi S, Richman DP, et al. Neuromuscular transmission in amyotrophic lateral sclerosis. Muscle Nerve 1993;16:1193-1203. (Pubitemid 23304857)
24. Tsujihata M, Hazama R, Yoshimura T, Satoh A, Mori M, Nagataki S. The motor end-plate fine structure and ultrastructural localization of acetylcholine receptors in amyotrophic lateral sclerosis. Muscle Nerve 1984;7:243-249. (Pubitemid 14150156)
25. Cole RN, Reddel SW, Gervásio OL, Phillips WD. Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction. Ann Neurol 2008;63:782-789.