Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells

Biochemical Pharmacology

Volumn 68, Issue 2, 2004, Pages 263-274

  Jang, Byeong Churl ^a   Paik, Ji Hye ^b   Jeong, Hye Yun ^a   Oh, Hyun Ji ^a   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a   Song, Dae Kyu ^a   Park, Jong Gu ^a   Kim, Sang Pyo ^a   Bae, Jae Hoon ^a   Mun, Kyo Chul ^a   Suh, Min Ho ^a   Yoshida, Minoru ^c   Suh, Seong Ii ^a  

^a Keimyung University School of Medicine   (South Korea)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c RIKEN   (Japan)

Author keywords

2 ,7 dichlorofluorescein diacetate; Asp Glu Val Asp p nitroanilide; BCR ABL; breakpoint cluster region abelson murine leukemia; chromosomal region maintenance 1; CRM1; DCFH DA; DEVD pNa; diphenyleneiodonium; DPI; IAP; inhibitor of apoptosis protein

Indexed keywords

ACETOACETIC ACID; ACETYLCYSTEINE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CYTOCHROME C; DICHLOROFLUORESCEIN; LEPTOMYCIN B; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CASPASES; CELL SURVIVAL; DOWN-REGULATION; ENZYME ACTIVATION; FATTY ACIDS, UNSATURATED; GENE EXPRESSION; HUMANS; LEUKEMIA; NEOPLASM PROTEINS; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; U937 CELLS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 2942610813     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.03.007     Document Type: Article

References (39)

1. Hamamoto T., Gunji S., Tsuji H., Beppu T. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation. J Antibiot Tokyo. 36:1983;39-45
2. Nishi K., Yoshida M., Fujiwara D., Nishikawa M., Horinouchi S., Beppu T. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem. 269:1994;6320-6324
3. Birbach A., Gold P., Binder B.R., Hofer E., de Martin R., Schmid J.A. Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus. J Biol Chem. 277:2002;10842-10851
4. Connor M.K., Kotchetkov R., Cariou S., Resch A., Lupetti R., Beniston R.G., et al. CRM1/Ran-mediated nuclear export of p27 (Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell. 14:2003;201-213
5. Gallouzi E., Brennan C.M., Steitz J.A. Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. RNA. 7:2001;1348-1361
6. Jang B.C., Munoz-Najar U., Paik J.H., Claffey K., Yoshida M., Hla T. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. J Biol Chem. 278:2003;2773-2776
7. Komiyama K., Okada K., Tomisaka S., Umezawa I., Hamamoto T., Beppu T. Antitumor activity of leptomycin B. J Antibiot (Tokyo). 38:1985;427-429
8. Yoshida M., Nishikawa M., Nishi K., Abe K., Horinouchi S., Beppu T. Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells. Exp Cell Res. 187:1990;150-156
9. Hietanen S., Lain S., Krausz E., Blattner C., Lane D.P. Activation of p53 in cervical carcinoma cells by small molecules. Proc Natl Acad Sci U.S.A. 97:2000;8501-8506
10. Lecane P.S., Kiviharju T.M., Sellers R.G., Peehl D.M. Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line. Prostate. 54:2003;258-267
11. Vigneri P., Wang J.Y. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat Med. 7:2001;228-234
12. Wyllie A.H., Kerr J.F., Currie A.R. Cell death: the significance of apoptosis. Int Rev Cytol. 68:1980;251-306
13. Cohen G.M. Caspases: the executioners of apoptosis. Biochem J. 326(Pt 1):1997;1-16
14. Deveraux Q.L., Reed J.C. IAP family proteins - suppressors of apoptosis. Genes Dev. 13:1999;239-252
15. Adams J.M., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 281:1998;1322-1326
16. Choi Y.J., Kim T.G., Kim Y.H., Lee S.H., Kwon Y.K., Suh S.I., et al. Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. Biochem Pharmacol. 66:2003;273-280
17. Kitada S., Zapata J.M., Andreeff M., Reed J.C. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood. 96:2000;393-397
18. Gojo I., Zhang B., Fenton R.G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res. 8:2002;3527-3538
19. Li Y.Z., Li C.Z., Pinto A.V., Pardee A.B. Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells. Mol Med. 5:1999;232-239
20. Fleury C., Mignotte B., Vayssiere J.L. Mitochondrial reactive oxygen species in cell death signaling. Biochimie. 84:2002;131-141
21. Jung U., Zheng X., Yoon S.O., Chung A.S. Se-methylselenocysteine induces apoptosis mediated by reactive oxygen species in HL-60 cells. Free Radic Biol Med. 31:2001;479-489
22. Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:1997;405-413
23. Festjens N., van Gurp M., van Loo G., Saelens X., Vandenabeele P. Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death. Acta Haematol. 111:2004;7-27
24. Rokhlin O.W., Guseva N., Tagiyev A., Knudson C.M., Cohen M.B. Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis. Oncogene. 20:2001;2836-2843
25. Kudo N., Matsumori N., Taoka H., Fujiwara D., Schreiner E.P., Wolff B., et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U.S.A. 96:1999;9112-9117
26. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:1994;346-347
27. Emoto Y., Manome Y., Meinhardt G., Kisaki H., Kharbanda S., Robertson M., et al. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 14:1995;6148-6156
28. Casciola-Rosen L., Nicholson D.W., Chong T., Rowan K.R., Thornberry N.A., Miller D.K., et al. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med. 183:1996;1957-1964
29. Deveraux Q.L., Takahashi R., Salvesen G.S., Reed J.C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388:1997;300-304
30. Shiozaki E.N., Chai J., Rigotti D.J., Riedl S.J., Li P., Srinivasula S.M., et al. Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell. 11:2003;519-527
31. Pardhasaradhi B.V., Ali A.M., Kumari A.L., Reddanna P., Khar A. Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS. Mol Cancer Ther. 2:2003;1165-1170
32. Oizumi S., Isobe H., Ogura S., Ishida T., Yamazaki K., Nishimura M., et al. Topoisomerase inhibitor-induced apoptosis accompanied by down-regulation of Bcl-2 in human lung cancer cells. Anticancer Res. 22:2002;4029-4037
33. Zhang B., Gojo I., Fenton R.G. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood. 99:2002;1885-1893
34. Park J.W., Choi Y.J., Suh S.I., Baek W.K., Suh M.H., Jin I.N., et al. Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis. 22:2001;1633-1639
35. Simon H.U., Haj-Yehia A., Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:2000;415-418
36. Sakurai T., Qu W., Sakurai M.H., Waalkes M.P. A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis. Chem Res Toxicol. 15:2002;629-637
37. Cuadrado A., Garcia-Fernandez L.F., Gonzalez L., Suarez Y., Losada A., Alcaide V., et al. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. J Biol Chem. 278:2003;241-250
38. De Vries N., De Flora S. N-acetyl-l-cysteine. J Cell Biochem Suppl. F17:1993;270-277
39. Pastore A., Federici G., Bertini E., Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta. 333:2003;19-39