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Volumn 9, Issue 6, 2014, Pages

Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN ANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; PLASMID DNA; PROTEIN ARGININE DEIMINASE; BACTERIAL PROTEIN; HYDROLASE; PROTEIN-ARGININE DEIMINASE;

EID: 84903538710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100838     Document Type: Article
Times cited : (88)

References (50)
  • 1
    • 0031152116 scopus 로고    scopus 로고
    • Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future directions
    • Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS (1997) Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 14: 216-48. (Pubitemid 127601178)
    • (1997) Periodontology 2000 , vol.1997 , Issue.14 , pp. 216-248
    • Page, R.C.1    Offenbacher, S.2    Schroeder, H.E.3    Seymour, G.J.4    Kornman, K.S.5
  • 2
    • 84877021027 scopus 로고    scopus 로고
    • Periodontal systemic associations: Review of the evidence
    • Linden GJ, Lyons A, Scannapieco FA (2013) Periodontal systemic associations: review of the evidence. J Clin Periodontol 40 Suppl 14: S8-19.
    • (2013) J Clin Periodontol , vol.40 , Issue.SUPPL. 14
    • Linden, G.J.1    Lyons, A.2    Scannapieco, F.A.3
  • 3
    • 68049116724 scopus 로고    scopus 로고
    • A Call to Action
    • Kornman KS (2009) A Call to Action. J Periodontol 80: 1019-1020.
    • (2009) J Periodontol , vol.80 , pp. 1019-1020
    • Kornman, K.S.1
  • 5
    • 28644451663 scopus 로고    scopus 로고
    • Periodontitis and rheumatoid arthritis: A review
    • DOI 10.1902/jop.2005.76.11-S.2066
    • Bartold PM, Marshall RI, Haynes DR (2005) Periodontitis and rheumatoid arthritis: a review. J Periodontol 76 (11 Suppl): 2066-2074. (Pubitemid 41748955)
    • (2005) Journal of Periodontology , vol.76 , Issue.11 SUPPL. , pp. 2066-2074
    • Bartold, P.M.1    Marshall, R.I.2    Haynes, D.R.3
  • 6
    • 70350004717 scopus 로고    scopus 로고
    • Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque
    • Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B, et al. (2009) Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque. Oral Microbiol Immunol 24: 469-477.
    • (2009) Oral Microbiol Immunol , vol.24 , pp. 469-477
    • Byrne, S.J.1    Dashper, S.G.2    Darby, I.B.3    Adams, G.G.4    Hoffmann, B.5
  • 7
    • 0034170113 scopus 로고    scopus 로고
    • The prevalence of pathogenic periodontal microflora in healthy young adult smokers
    • Shiloah J, Patters MR, Waring MB (2000) The prevalence of pathogenic periodontal microflora in healthy young adult smokers. J Periodontol 71: 562-567.
    • (2000) J Periodontol , vol.71 , pp. 562-567
    • Shiloah, J.1    Patters, M.R.2    Waring, M.B.3
  • 8
    • 0036835212 scopus 로고    scopus 로고
    • Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction
    • DOI 10.1034/j.1600-051X.2002.291107.x
    • van Winkelhoff AJ, Loos BG, van der Reijden WA, van der Velden U (2002) Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J Clin Periodontol 29: 1023-1028. (Pubitemid 41697772)
    • (2002) Journal of Clinical Periodontology , vol.29 , Issue.11 , pp. 1023-1028
    • Van Winkelhoff, A.J.1    Loos, B.G.2    Van Der, R.W.A.3    Van Der, V.U.4
  • 9
    • 0033004481 scopus 로고    scopus 로고
    • Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase
    • McGraw WT, Potempa J, Farley D, Travis J (1999) Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 67: 3248-3256. (Pubitemid 29291488)
    • (1999) Infection and Immunity , vol.67 , Issue.7 , pp. 3248-3256
    • McGraw, W.T.1    Potempa, J.2    Farley, D.3    Travis, J.4
  • 10
    • 84889088138 scopus 로고    scopus 로고
    • Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis
    • Holers VM (2013) Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis. Curr Op Immunol 25: 728-735.
    • (2013) Curr Op Immunol , vol.25 , pp. 728-735
    • Holers, V.M.1
  • 12
    • 0035869593 scopus 로고    scopus 로고
    • The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha-and beta-chains of fibrin
    • Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, et al. (2001) The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 166: 4177-4184. (Pubitemid 32224951)
    • (2001) Journal of Immunology , vol.166 , Issue.6 , pp. 4177-4184
    • Masson-Bessiere, C.1    Sebbag, M.2    Girbal-Neuhauser, E.3    Nogueira, L.4    Vincent, C.5    Senshu, T.6    Serre, G.7
  • 14
    • 0036231529 scopus 로고    scopus 로고
    • Posttranslational protein modifications: New flavors in the menu of autoantigens
    • DOI 10.1097/00002281-200205000-00009
    • Doyle HA, Mamula MJ (2002) Posttranslational protein modifications: new flavors in the menu of autoantigens. Curr Opin Rheumatol 14: 244-249. (Pubitemid 34439088)
    • (2002) Current Opinion in Rheumatology , vol.14 , Issue.3 , pp. 244-249
    • Doyle, H.A.1    Mamula, M.J.2
  • 15
    • 27144482048 scopus 로고    scopus 로고
    • Hypothesis: The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis
    • DOI 10.1007/s10753-004-6641-z
    • Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G (2004) Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 28: 311-318. (Pubitemid 41504274)
    • (2004) Inflammation , vol.28 , Issue.6 , pp. 311-318
    • Rosenstein, E.D.1    Greenwald, R.A.2    Kushner, L.J.3    Weissmann, G.4
  • 16
    • 73249145617 scopus 로고    scopus 로고
    • Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    • Wegner N, Lundberg K, Kinloch A, Fisher B, Malmström V, et al. (2010) Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev 233: 34-54.
    • (2010) Immunol Rev , vol.233 , pp. 34-54
    • Wegner, N.1    Lundberg, K.2    Kinloch, A.3    Fisher, B.4    Malmström, V.5
  • 17
    • 77955733490 scopus 로고    scopus 로고
    • Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: Implications for autoimmunity in rheumatoid arthritis
    • Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, et al. (2010) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62: 2662-2672.
    • (2010) Arthritis Rheum , vol.62 , pp. 2662-2672
    • Wegner, N.1    Wait, R.2    Sroka, A.3    Eick, S.4    Nguyen, K.A.5
  • 18
    • 0029285787 scopus 로고
    • PCR-mediated recombination and mutagenesis. SOEing together tailor-made genes
    • Horton RM (1995) PCR-mediated recombination and mutagenesis. SOEing together tailor-made genes. Mol Biotechnol 3: 93-99.
    • (1995) Mol Biotechnol , vol.3 , pp. 93-99
    • Horton, R.M.1
  • 19
  • 20
    • 0034669530 scopus 로고    scopus 로고
    • A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline
    • Knipp M, Vasak M (2000) A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline. Anal Biochem 286: 257-264.
    • (2000) Anal Biochem , vol.286 , pp. 257-264
    • Knipp, M.1    Vasak, M.2
  • 21
    • 84884590924 scopus 로고    scopus 로고
    • Porphyromonas gingivalis peptidylarginine deiminase substrate specificity
    • Abdullah SN, Farmer EA, Spargo L, Logan R, Gully N (2013) Porphyromonas gingivalis peptidylarginine deiminase substrate specificity. Anaerobe 23: 102-108.
    • (2013) Anaerobe , vol.23 , pp. 102-108
    • Abdullah, S.N.1    Farmer, E.A.2    Spargo, L.3    Logan, R.4    Gully, N.5
  • 22
    • 65349144256 scopus 로고    scopus 로고
    • The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis
    • Cantley MD, Bartold PM, Marino V, Reid RC, Fairlie DP, et al. (2009) The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis. J Periodontal Res 44: 317-322.
    • (2009) J Periodontal Res , vol.44 , pp. 317-322
    • Cantley, M.D.1    Bartold, P.M.2    Marino, V.3    Reid, R.C.4    Fairlie, D.P.5
  • 23
    • 79955889179 scopus 로고    scopus 로고
    • Pre-existing periodontitis exacerbates experimental arthritis in a mouse model
    • Cantley MD, Haynes DR, Marino V, Bartold PM (2011) Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. J Clin Periodontol. 38: 532-541.
    • (2011) J Clin Periodontol , vol.38 , pp. 532-541
    • Cantley, M.D.1    Haynes, D.R.2    Marino, V.3    Bartold, P.M.4
  • 24
    • 0042476389 scopus 로고    scopus 로고
    • Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB
    • DOI 10.1002/eji.200323810
    • Nandakumar KS, Andrén M, Martinsson P, Bajtner E, Hellström S, et al. (2003) Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. Eur J Immunol 33: 2269-2277. (Pubitemid 37010045)
    • (2003) European Journal of Immunology , vol.33 , Issue.8 , pp. 2269-2277
    • Nandakumar, K.S.1    Andren, M.2    Martinsson, P.3    Bajtner, E.4    Hellstrom, S.5    Holmdahl, R.6    Kleinau, S.7
  • 25
    • 33847774370 scopus 로고    scopus 로고
    • Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair
    • Park CH, Abramson ZR, Taba M Jr, Jin Q, Chang J, et al. (2007) Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair. J Periodontol 78: 273-281.
    • (2007) J Periodontol , vol.78 , pp. 273-281
    • Park, C.H.1    Abramson, Z.R.2    Taba Jr., M.3    Jin, Q.4    Chang, J.5
  • 26
    • 75549088819 scopus 로고    scopus 로고
    • MicrobesOnline: An integrated portal for comparative and functional genomics
    • Dehal PS, Joachimiak MP, Price MN, Bates JT, Baumohl JK, et al. (2010) MicrobesOnline: an integrated portal for comparative and functional genomics. Nucleic Acids Res 38 (Database issue): D396-400.
    • (2010) Nucleic Acids Res , vol.38 , Issue.DATABASE ISSUE
    • Dehal, P.S.1    Joachimiak, M.P.2    Price, M.N.3    Bates, J.T.4    Baumohl, J.K.5
  • 28
    • 84890229045 scopus 로고    scopus 로고
    • When and where does inflammation begin in rheumatoid arthritis
    • Demoruelle MK, Deane KD, Holers VM (2014) When and where does inflammation begin in rheumatoid arthritis. Curr Opin Rheumatol 26: 64-71.
    • (2014) Curr Opin Rheumatol , vol.26 , pp. 64-71
    • Demoruelle, M.K.1    Deane, K.D.2    Holers, V.M.3
  • 29
    • 84874382377 scopus 로고    scopus 로고
    • Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva
    • Harvey GP, Fitzsimmons TR, Dhamarpatni AA, Marchant C, Haynes DR, et al. (2013) Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res 48: 252-261.
    • (2013) J Periodontal Res , vol.48 , pp. 252-261
    • Harvey, G.P.1    Fitzsimmons, T.R.2    Dhamarpatni, A.A.3    Marchant, C.4    Haynes, D.R.5
  • 31
    • 0142213223 scopus 로고    scopus 로고
    • Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice: Description of the Disease and the Influence of Age, Sex, and Genes
    • Nandakumar KS, Svensson L, Holmdahl R (2003) Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol 163: 1827-1837. (Pubitemid 37310014)
    • (2003) American Journal of Pathology , vol.163 , Issue.5 , pp. 1827-1837
    • Nandakumar, K.S.1    Svensson, L.2    Holmdahl, R.3
  • 32
    • 84884236003 scopus 로고    scopus 로고
    • Antibody-induced arthritis: Disease mechanisms and genes involved at the effector phase of arthritis
    • 2006
    • Nandakumar KS, Holmdahl R (2006) Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis. Arthritis Res Ther 2006; 8: 223-234.
    • (2006) Arthritis Res Ther , vol.8 , pp. 223-234
    • Nandakumar, K.S.1    Holmdahl, R.2
  • 34
    • 84861966502 scopus 로고    scopus 로고
    • Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis
    • Thiele GM, Duryee MJ, Dusad A, Hunter CD, Lacy JP, et al. (2012) Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis. Int Immunopharmacol 13: 424-431.
    • (2012) Int Immunopharmacol , vol.13 , pp. 424-431
    • Thiele, G.M.1    Duryee, M.J.2    Dusad, A.3    Hunter, C.D.4    Lacy, J.P.5
  • 35
    • 33645511657 scopus 로고    scopus 로고
    • Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
    • Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, et al. (2006) Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 116: 961-973.
    • (2006) J Clin Invest , vol.116 , pp. 961-973
    • Kuhn, K.A.1    Kulik, L.2    Tomooka, B.3    Braschler, K.J.4    Arend, W.P.5
  • 36
    • 79955006474 scopus 로고    scopus 로고
    • N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis
    • Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, et al. (2011) N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J Immunol 186: 4396-4404.
    • (2011) J Immunol , vol.186 , pp. 4396-4404
    • Willis, V.C.1    Gizinski, A.M.2    Banda, N.K.3    Causey, C.P.4    Knuckley, B.5
  • 37
    • 84884677299 scopus 로고    scopus 로고
    • Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)
    • Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, et al. (2013) Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog 9: e1003627.
    • (2013) PLoS Pathog , vol.9
    • Maresz, K.J.1    Hellvard, A.2    Sroka, A.3    Adamowicz, K.4    Bielecka, E.5
  • 38
    • 84891509937 scopus 로고    scopus 로고
    • Oxantel disrupts polymicrobial biofilm development of periodontal pathogens
    • doi:10.1128/AAC.01375-13. Epub 2013 Oct 28
    • Dashper S, O'Brien-Simpson N, Liu SW, Paolini R, Mitchell H, et al. (2014) Oxantel disrupts polymicrobial biofilm development of periodontal pathogens. Antimicrob Agents Chemother. 58: 378-85. doi:10.1128/AAC.01375-13. Epub 2013 Oct 28.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 378-385
    • Dashper, S.1    O'Brien-Simpson, N.2    Liu, S.W.3    Paolini, R.4    Mitchell, H.5
  • 39
    • 0029300917 scopus 로고
    • Protective immunity to Porphyromonas gingivalis infection in a murine model
    • Bird PS, Gemmell E, Polak B, Paton RG, Sosroseno W, et al. (1995). Protective immunity to Porphyromonas gingivalis infection in a murine model. J. Periodontol 66: 351-362.
    • (1995) J. Periodontol , vol.66 , pp. 351-362
    • Bird, P.S.1    Gemmell, E.2    Polak, B.3    Paton, R.G.4    Sosroseno, W.5
  • 40
    • 0032404139 scopus 로고    scopus 로고
    • Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine model
    • Kesavalu L, Holt SC, Ebersole JL (1998) Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine model. Oral Microbiol Immunol 13: 373-377. (Pubitemid 28519461)
    • (1998) Oral Microbiology and Immunology , vol.13 , Issue.6 , pp. 373-377
    • Kesavalu, L.1    Holt, S.C.2    Ebersole, J.L.3
  • 41
    • 0035192014 scopus 로고    scopus 로고
    • Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model
    • DOI 10.1128/IAI.69.12.7527-7534.2001
    • O'Brien-Simpson NM, Paolini RA, Hoffmann B, Slakeski N, Dashper SG, et al. (2001) Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model. Infect. Immun 69: 7527-7534. (Pubitemid 33086579)
    • (2001) Infection and Immunity , vol.69 , Issue.12 , pp. 7527-7534
    • O'Brien-Simpson, N.M.1    Paolini, R.A.2    Hoffmann, B.3    Slakeski, N.4    Dashper, S.G.5    Reynolds, E.C.6
  • 42
    • 33747111651 scopus 로고    scopus 로고
    • Characterization of proteinase-adhesin complexes of Porphyromonas gingivalis
    • DOI 10.1099/mic.0.28787-0
    • Pathirana RD, O'Brien-Simpson NM, Veith PD, Riley PF, Reynolds EC(2006) Characterization of proteinase-adhesin complexes of Porphyromonas gingivalis. Microbiology 152: 2381-2394. (Pubitemid 44219645)
    • (2006) Microbiology , vol.152 , Issue.8 , pp. 2381-2394
    • Pathirana, R.D.1    O'Brien-Simpson, N.M.2    Veith, P.D.3    Riley, P.F.4    Reynolds, E.C.5
  • 44
    • 79960080266 scopus 로고    scopus 로고
    • Synergistic virulence of Treponema denticola and Porphyromonas gingivalis in a murine periodontitis model
    • Orth RK, O'Brien-Simpson NM, Dashper SG, Reynolds EC (2011) Synergistic virulence of Treponema denticola and Porphyromonas gingivalis in a murine periodontitis model. Molecular Oral Microbiology 26: 229-240.
    • (2011) Molecular Oral Microbiology , vol.26 , pp. 229-240
    • Orth, R.K.1    O'Brien-Simpson, N.M.2    Dashper, S.G.3    Reynolds, E.C.4
  • 45
    • 0036117913 scopus 로고    scopus 로고
    • Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model
    • Rajapakse PS, O'Brien-Simpson NM, Slakeski N, Hoffmann B, Reynolds EC (2002) Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model. Infect Immun 70: 2480-2424
    • (2002) Infect Immun , vol.70 , pp. 2480-12424
    • Rajapakse, P.S.1    O'Brien-Simpson, N.M.2    Slakeski, N.3    Hoffmann, B.4    Reynolds, E.C.5
  • 46
    • 56949106332 scopus 로고    scopus 로고
    • Evolutionarily conserved antigens in autoimmune disease: Implications for an infective aetiology
    • Wegner N, Wait R, Venables PJ (2009) Evolutionarily conserved antigens in autoimmune disease: implications for an infective aetiology. Int J Biochem Cell Biol 41: 390-397.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 390-397
    • Wegner, N.1    Wait, R.2    Venables, P.J.3
  • 47
    • 84867229779 scopus 로고    scopus 로고
    • Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune disease
    • Jeong E, Lee J-Y, Kim S-J, Choi J (2012) Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune disease. J Periodont Res 47: 811-816.
    • (2012) J Periodont Res , vol.47 , pp. 811-816
    • Jeong, E.1    Lee, J.-Y.2    Kim, S.-J.3    Choi, J.4
  • 48
    • 84862754642 scopus 로고    scopus 로고
    • The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation
    • Nesse W, Westra J, van der Wal JE, Abbas F, Nicholas AP, et al. (2012) The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol 39: 599-607.
    • (2012) J Clin Periodontol , vol.39 , pp. 599-607
    • Nesse, W.1    Westra, J.2    Van Der Wal, J.E.3    Abbas, F.4    Nicholas, A.P.5
  • 49
    • 84889663283 scopus 로고    scopus 로고
    • Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: A potential mechanism for breaching immunologic tolerance in rheumatoid arthritis
    • Quirke AM, Lugli EB, Wegner N, Hamilton BC, Charles P, et al. (2014) Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis 73: 263-269.
    • (2014) Ann Rheum Dis , vol.73 , pp. 263-269
    • Quirke, A.M.1    Lugli, E.B.2    Wegner, N.3    Hamilton, B.C.4    Charles, P.5
  • 50
    • 84864867893 scopus 로고    scopus 로고
    • Periodontal disease is significantly higher in non-smoking treatment-naïve rheumatoid arthritis patients: Results from a case-control study
    • Potikuri D, Dannana KC, Kanchinadam S, Agrawal S, Kancharla A, et al. (2012) Periodontal disease is significantly higher in non-smoking treatment-naïve rheumatoid arthritis patients: results from a case-control study. Ann Rheum Dis 71: 1541-1544.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1541-1544
    • Potikuri, D.1    Dannana, K.C.2    Kanchinadam, S.3    Agrawal, S.4    Kancharla, A.5


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