Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine model

Oral Microbiology and Immunology

Volumn 13, Issue 6, 1998, Pages 373-377

  Kesavalu, L ^a   Holt, S C ^a   Ebersole, J L ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Mouse; Porphyromonas gingivalis; Treponema denticola; Trypsin like protease; Virulence

Indexed keywords

EID: 0032404139     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-302X.1998.tb00694.x     Document Type: Article

References (57)

1. Bedi GS. Purification and characterization of lysine- and arginine-specific gingivain proteases from Porphyromonas gingivalis. Prep Biochem 1994: 24: 251-261.
2. Chen PB, Davern LB, Neiders ME, Reynolds HS, Zambon JJ. Analysis of in vitro lymphoproliferative response and antibody formation following subcutaneous injection of Actinobacillus and Wolinella recta in a murine model. Oral Microbiol Immunol 1991: 6: 12-16.
3. Choi BK. Wyss C, Gobel UB. Phylogenetic analysis of pathogen-related oral spirochetes. J Clin Microbiol 1996: 34: 1922-1925.
4. Chu L, Ebersole JL, Kurzban G, Holt SC. Cystalysin, a 46-kilodalton cysteine desulfhydrase from Treponema denticola, with hemolytic and hemoxydative activities. Infect Immun 1997: 65: 3231-3238.
5. Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 1997: 14: 12-32.
6. Ebersole JL. Feuille F, Kesavalu L, Holt SC. Host modulation of tissue destruction caused by periodontopathogens: effects on a mixed microbial infection composed of Porphyromonas gingivalis and Fusobacterium nucleatum. Microb Pathog 1997. 23: 23-32.
7. Ebersole JL, Kesavalu L. Schneider SL, Machen RL, Holt SC. Comparative virulence of periodontopathogens in a mouse abscess model. Oral Dis 1995: 1: 115-128.
8. Evans RT, Klaussen B, Genco RJ. Immunization with fimbrial protein and peptide protects against Porphyromonas gingivalis induced periodontal tissue destruction. Adv Exp Med Biol 1992: 527: 255-262.
9. Feuille F, Ebersole JL, Kesavalu L, Steffen MJ, Holt SC. Mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a murine model: potential synergistic effects on virulence. Infect Immun 1996: 64: 2095-2100.
10. Fletcher HM, Schenkein HA, Macrina FL. Cloning and characterization of a new protease gene (prtH) from Porphyromonas gingivalis. Infect Immun 1994: 62: 4279-4286.
11. Genco CA, Cutler CW, Kapczynski D, Maloney H, Arnold RR. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun 1991: 59: 1255-1263.
12. Grenier D. Demonstration of a bimodal coaggregation reaction between Porphyromonas gingivalis and Treponema denticola. Oral Microbiol Immunol 1992: 7: 280-84.
13. Grenier D. Nutritional interactions between two suspected periodontopathogens. Treponema denticola and Porphyromonas gingivalis. Infect Immun 1992: 60: 5298-5301.
14. Grenier D, Uitto V, McBride BC. Cellular location of a Treponema denticola chymotrypsin-like protease and importance of the protease in migration through the basement membrane. Infect Immun 1990: 58: 347-351.
15. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994: 5: 78-111.
16. Holt SC, Bramanti TE. Factors in virulence expression and their role in periodontal disease pathogenesis. Crit Rev Oral Biol Med 1991: 2: 177-281.
17. Holt SC, Ebersole JL, Felton J, Brunsvold M, Kornman KS. Implantation of Bacteroides gingivalis in non-human primates initiates progression of penodontitis. Science 1988: 239: 55-57.
18. Hoover CI, Ng CY, Felton JR. Correlation of haemagglutination activity with trypsin-like protease activity of Porphyromonas gingivalis. Arch Oral Biol 1992: 37: 515-520.
19. Johnson BD, Engel D. Acute necrotizing ulcerative gingivitis: a review of diagnosis, etiology and treatment. J Periodontol 1986: 57: 141-150.
20. Kauffman J, DiRienzo JM. Isolation of a corncob (coaggregation) receptor polypeptide from Fusobacterium nucleatum. Infect Immun 1989: 57: 331-337.
21. Kesavalu L, Ebersole JL, Machen RL, Holt SC. Porphyromonas gingivalis virulence in mice: Induction of immunity to bacterial components. Infect Immun 1992: 60: 1455-1464.
22. Kesavalu L, Holt SC, Crawley RR, Borinski R, Ebersole JL. Virulence of Wolinella recta in a murine abscess model. Infect Immun 1991: 59: 2806-2817.
23. Kesavalu L, Holt SC, Ebersole JL. Trypsin-like protease activity of Porphyromonas gingivalis as a potential virulence factor in a murine lesion model. Microb Pathog 1996: 20: 1-10.
24. Kesavalu L, Walker S, Holt SC, Crawley RR, Ebersole JL. Virulence characteristics of oral treponemes in a murine model. Infect Immun 1997: 65: 5096-5102.
25. Kesavalu L, Holt SC, Ebersole JL. Hydrolytic enzymes of Porphyromonas gingivalis: In vitro distribution and functions. Int J Oral Biol 1997: 22: 255-267.
26. Kinder S. Interbacterial adherence between two gram-negative anaerobes, Porphyromonas gingivalis and Fusobacterium nucleaium. Thesis, 1993: 11-13, University of Texas Health Science Center at San Antonio.
27. Kinder S, Holt SC. Characterization of coaggregation between Bacteroides gingivalis T22 and Fusobacterium nucleatum T18. Infect Immun 1991: 57: 3425-3433.
28. Kolenbrander PE. Surface recognition among oral bacteria: multigeneric coaggregations and their mediators. Crit Rev Microbiol 1989: 17: 137-175.
29. Lala A, Anamo A, Sojar HT, Radel SJ, De Nardin E. Porphyromonas gingivalis trypsin-like protease: a possible natural ligand for the neutrophil formyl peptide receptor. Biochem Biophys Res Commun 1994: 199: 1489-1496.
30. Li J, Ellen RP, Hoover CI, Felton JR. Association of proteases of Porphyromonas (Bacteroides) gingivalis with its adhesion to Actinomyces viscosus. J Dent Res 1991: 70: 82-86.
31. Loesche WJ. The role of spirochetes in periodontal disease. Adv Dent Res 1988: 2: 275-283.
32. Madden TE, Caton JG. Animal models for periodontal disease. Methods Enzymol 1994: 236: 106-119.
33. Madden DL, Fujiwara K. Selected bacterial diseases. In: Faster HL, Small JD, Fox JG, ed. The mouse in biomedical research. Vol. IV. Experimental biology and oncology. New York: Academic Press, 1982: 257-270.
34. McKee AS, McDermid AS, Wait R, Baskerville A, Marsh PD. Isolation of colonial variants of Bacteroides gingivalis W50 with a reduced virulence. J Med Microbiol 1988: 27: 59-64.
35. Moore WEC, Moore LVH. The bacteria of periodontal diseases. Periodontol 2000 1994: 5: 66-77.
36. Murray PA. HIV disease as a risk factor for periodontal disease. Compendium Cont Educ Dent 1994: 15. 1052-1063.
37. Neiders ME, Chen PB, Suido H, Reynolds HS, Zambon JJ, Genco RJ. Heterogeneity of virulence among strains of Bacteroides gingivalis. J Periodont Res 1989: 24: 192-198
38. Nilius AM, Spencer SC, Simonson LG. Stimulation of in vitro growth of Treponema denticola by extracellular growth factors produced by Porphyromonas gingivalis. J Dent Res 1993: 72: 1027-1031.
39. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 1991: 26: 230-242.
40. Pavloff N, Potempa J, Pike RN, Prochazka V, Kiefer MC, Travis J, Barr PJ. Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem 1995: 270: 1007-1010.
41. Rams TE, Andriolo M, Feik D, Abel SN, McGivern TM, Slots J. Microbiological study of HIV-related periodontitis. J Periodontol 1991: 62: 74-81.
42. Ranney RR. Immunologic mechanisms of pathogenesis in periodontal diseases: An assessment. J Periodont Res 1991: 26: 243-254.
43. Riviere GR, Wagoner MA, Baker-Zander SA, Weisz KS, Adams DF, Simonson L, Lukehart SA. Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. N Engl J Med 1991: 325: 539-543.
44. Riviere GR, Smith KS, Carranza N Jr, Tzagaroulaki E, Kay SL, Dock M, Zhu X, DeRouen TA. Associations between Porphyromonas gingivalis and oral treponemes in subgingival plaque. Oral Microbiol Immunol 1996: 11: 150-155.
45. Rosenstein DI, Riviere GR, Elott K. HIV-associated periodontal disease: new oral spirochete found. J Am Dent Assoc 1993: 124: 76-80.
46. Simonson LG, McMahon KT, Childers DW, Morton HE. Bacterial synergy of Treponema denticola and Porphyromonas gingivalis in a multinational population. Oral Microbiol Immunol 1992: 7: 111-112.
47. Simonson LG, Goodman CH, Morton HE. Quantitative immunoassay of Treponema denticola serovar in adult periodontitis. J Clin Microbiol 1990: 28: 1493-1496.
48. Slots J, Rams TE. Microbiology of periodontal disease. In: Slots J, Taubman MA, ed. Comtemporary oral microbiology and immunology St. Louis: Mosby Year Book, 1992: 425-430.
49. Smibert RM, Burmeister JA. Treponema pectinovorum sp. nov. isolated from humans with periodontitis. Int J Syst Bacteriol 1983: 33: 852-856.
50. Smibert RM, Johnson JL, Ranney RR, Treponema socranskii sp. nov.; Treponema socranskii subsp. socranskii subsp. nov; Treponema socranskii susp. buccale subsp. nov.: and Treponema socranskii subsp. paredis subsp. nov. isolated from humans with experimental gingivitis and periodontitis. Int J Syst Bacteriol 1984: 34: 456-462.
51. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000 1994: 5: 7-25.
52. Socransky SS, Haffajee AD, Dzink JL, Hillman JD. Associations between microbial species in subgingival samples. Oral Microbiol Immunol 1988: 3: 1-7.
53. Syed SA, Loesche WJ. Survival of human dental plaque flora in various transport media. Appl Microbiol 1972: 24: 638-644.
54. Taubman MA, Yoshie H, Ebersole JL, Smith DJ, Olson CL. Host response in experimental periodontal disease. J Dent Res 1984. 63. 455-460.
55. Uitto VJ, Haapasalo M, Laakso T, Salo T. Degradation of basement membrane collagen by proteases from some anaerobic oral micro-organisms. Oral Microbiol Immunol 1988: 3: 97-102.
56. Walker SG, Ebersole JL, Holt SC. Identification, isolation, and characterization of the 42-kilodalton major outer membrane protein (MompA) from Treponema pectinovorum ATCC 33768. J Bacteriol 1997: 179: 6441-6447.
57. Winkler JR, Murray PA, Grassi M, Hammerle C. Diagnosis and management of HIV-associated periodontal diseases. J Am Dent Assoc 1989: 1: 25S-34S.