Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva

Journal of Periodontal Research

Volumn 48, Issue 2, 2013, Pages 252-261

  Harvey, G P ^a   Fitzsimmons, T R ^a   Dhamarpatni, A A S S K ^a   Marchant, C ^a   Haynes, D R ^a   Bartold, P M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Anti citrullinated proteins; Chronic inflammation; Citrullination; Periodontitis; Rheumatoid arthritis

Indexed keywords

3 AMINO 9 ETHYLCARBAZOLE; 3-AMINO-9-ETHYLCARBAZOLE; AUTOANTIBODY; CARBAZOLE DERIVATIVE; CITRULLINE; COLORING AGENT; DIAGNOSTIC AGENT; HYDROLASE; PEPTIDYLARGININE DEIMINASE TYPE IV; PROTEIN; PROTEIN ARGININE DEIMINASE; PROTEIN-ARGININE DEIMINASE;

ADULT; AGGRESSIVE PERIODONTITIS; ARTICLE; CHEMISTRY; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; ENDOTHELIUM CELL; ENZYME IMMUNOASSAY; FEMALE; FIBROBLAST; GINGIVA; GINGIVA BLEEDING; GINGIVA DISEASE; GINGIVITIS; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOLOGY; PERIODONTAL POCKET; PERIODONTITIS; SMOKING;

ADULT; AGGRESSIVE PERIODONTITIS; AUTOANTIBODIES; CARBAZOLES; CHRONIC PERIODONTITIS; CITRULLINE; COLORING AGENTS; ENDOTHELIAL CELLS; FEMALE; FIBROBLASTS; GINGIVA; GINGIVAL CREVICULAR FLUID; GINGIVAL HEMORRHAGE; GINGIVAL RECESSION; HUMANS; HYDROLASES; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; PERIODONTAL POCKET; PERIODONTITIS; PROTEINS; SMOKING;

EID: 84874382377     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/jre.12002     Document Type: Article

References (48)

1. Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol 2005;76:2066-2074.
2. de Pablo P, Chapple IL, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol 2009;5:218-224.
3. Bridges SL. Update on autoantibodies in rheumatoid arthritis. Curr Rheumatol Rep 2004;6:343-350.
4. Aletaha D, Neogi T, Silman AJ, Funovits J et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:2569-2581.
5. Rantapaa-Dahlqvist S, de Jong BABerglin E et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003;48:2741-2749.
6. Kroot EJ, de Jong BA, van Leeuwen M et al. Prognostic value of anti-cyclic citrullinated peptide antibody in recent-onset rheumatoid arthritis. Arthritis Rheum 2000;43:1831-1835.
7. Vossenaar ER, Radstake TR, van der Heijden A et al. Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann Rheum Dis 2004;63:373-381.
8. Foulquier C, Sebbag M, Clavel C et al. Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum 2007;56:3541-3553.
9. McGraw WT, Potempa J, Farley D, Travis J. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 1999;67:3248-3256.
10. Ghosh S, Collins FS. The geneticist's approach to complex disease. Annu Rev Med 1996;47:333-353.
11. Thé J, Ebersole JL. Rheumatoid factor from periodontitis patients cross-reacts with epitopes on oral bacteria. Oral Dis 1996;2:253-262.
12. Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 2004;28:311-318.
13. Thé J, Ebersole JL. Rheumatoid factor (RF) distribution in periodontal disease. J Clin Immunol 1991;11:132-142.
14. Dissick A, Redman RS, Jones M et al. Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol 2010;81:223-230.
15. Havemose-Poulsen A, Westergaard J, Stoltze K et al. Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 2006;77:280-288.
16. Hendler A, Mulli TK, Hughes FJ et al. Involvement of autoimmunity in the pathogenesis of aggressive periodontitis. J Dent Res 2010;89:1389-1394.
17. Lundberg K, Wegner N, Yucel-Lindberg T et al. Periodontitis in RA - the citrullinated enolase connection. Nat Rev Rheumatol 2010;6:727-730.
18. Nesse W, Westra J, van der Wal JE et al. The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol 2012;39:599-607.
19. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
20. Tak PP, van der Lubbe PA, Cauli A, Daha MR et al. Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum 1995;38:1457-1465.
21. Kraan MC, Haringman JJ, Ahern MJ. Quantification of the cell infiltrate in synovial tissue by digital image analysis. Rheumatology (Oxford) 2000;39:43-49.
22. Kataria NG, Bartold PM, Dharmapatni AA, Atkins GJ, Holding CA, Haynes DR. Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis. J Periodontal Res 2010;45:564-573.
23. Méchin MC, Coudane F, Adoue V et al. Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases. Cell Mol Life Sci 2010;67:1491-1503.
24. Megson E, Fitzsimmons T, Dharmapatni AA. C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation. J Clin Periodontol 2010;37:797-804.
25. Gyorgy B, Toth E, Tarcsa E, Falus A, Buzás EI. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol 2006;38:1662-1677.
26. Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 2001;166:4177-4184.
27. Lundberg K, Nijenhuis S, Vossenaar ER et al. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res Ther 2005;7:R458-R467.
28. Makrygiannakis D, af Klint E, Lundberg IE et al. Citrullination is an inflammation-dependent process. Ann Rheum Dis 2006;65:1219-1222.
29. De Rycke L, Nicholas AP, Cantaert T et al. Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity. Arthritis Rheum 2005;52:2323-2330.
30. Vossenaar ER, Smeets TJ, Kraan MC, Raats JM, van Venrooij WJ, Tak PP. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue. Arthritis Rheum 2004;50:3485-3494.
31. Schellekens GA, Visser H, de Jong BA et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000;43:155-163.
32. Symmons DP, Barrett EM, Bankhead CR, Scott DG, Silman AJ. The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol 1994;33:735-739.
33. Bogliolo L, Alpini C, Caporali R, Scirè CA, Moratti R, Montecucco C. Antibodies to cyclic citrullinated peptides in psoriatic arthritis. J Rheumatol 2005;32:511-515.
34. Hoffman IE, Peene I, Cebecauer L et al. Presence of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus. Ann Rheum Dis 2005;64:330-332.
35. Gottenberg JE, Mignot S, Nicaise-Rolland P et al. Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren's syndrome. Ann Rheum Dis 2005;64:114-117.
36. Atzeni F, Sarzi-Puttini P, Lama N et al. Anti-cyclic citrullinated peptide antibodies in primary Sjogren syndrome may be associated with non-erosive synovitis. Arthritis Res Ther 2008;10:R51.
37. Ballini A, Tete S, Scattarella A et al. The role of anti-cyclic citrullinated peptide antibody in periodontal disease. Int J Immunopathol Pharmacol 2010;3:677-681.
38. Golub LM, Payne JB, Reinhardt RA, Nieman G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical "two-hit" model. J Dent Res 2006;85:102-105.
39. Ramamurthy NS, Greenwald RA, Celiker MY, Shi EY. Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases. J Periodontol 2005;76:229-233.
40. Bartold PM, Marino V, Cantley M, Haynes DR. Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol 2010;37:405-411.
41. Cantley MD, Haynes DR, Marino V, Bartold PM. Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. J Clin Periodontol 2011;38:532-541.
42. Chang X, Yamada R, Suzuki A et al. Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology (Oxford) 2005;44:40-50.
43. Chang X, Han J. Expression of peptidylarginine deiminase type 4 (PAD-4) in various tumors. Mol Carcinog 2006;45:183-196.
44. Chang X, Han J, Pang L, Zhao Y, Yang Y, Shen Z. Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer 2009;9:40.
45. Riviere GR, Smith KS, Tzagaroulaki E et al. Periodontal status and detection frequency of bacteria at sites of periodontal health and gingivitis. J Periodontol 1996;67:109-115.
46. Guyodo H, Meuric V, Pottier L et al. Colocalization of Porphyromonas gingivalis with CD4+ T cells in periodontal disease. FEMS Immunol Med Microbiol 2012;64:175-183.
47. Armitage GC. Classifying periodontal diseases - a long-standing dilemma. Periodontol 2000 2002;30:9-23.
48. Hugoson A, Jordan T. Frequency distribution of individuals aged 20-70 years according to severity of periodontal disease. Community Dent Oral Epidemiol 1982;10:187-192.