Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo

Journal of Medicinal Chemistry

Volumn 57, Issue 12, 2014, Pages 5333-5347

  Fancelli, Daniele ^a,b   Abate, Agnese ^a,f   Amici, Raffaella ^a,b   Bernardi, Paolo ^d   Ballarini, Marco ^a,b   Cappa, Anna ^a,b   Carenzi, Giacomo ^a,g   Colombo, Andrea ^e,h   Contursi, Cristina ^a,i   Di Lisa, Fabio ^d   Dondio, Giulio ^e,j   Gagliardi, Stefania ^e,k   Milanesi, Eva ^a   Minucci, Saverio ^b,c   Pain, Gilles ^a,l   Pelicci, Pier Giuseppe ^b   Saccani, Alessandra ^a,m   Storto, Mariangela ^a,b   Thaler, Florian ^a,b   Varasi, Mario ^a,b   Villa, Manuela ^a,b   Plyte, Simon ^a,n   more..

^a Genextra Group   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

^e NiKem Research   (Italy)

^f TEMPLE UNIVERSITY   (United States)

^g Fondazione Istituto Insubrico Ricerca Per la Vita   (Italy)

^h Teva Pharmaceuticals Fine Chemicals   (Italy)

ⁱ R and D Laboratory Oxon Italia SPA   (Italy)

^j Aphad Srl   (Italy)

^k Flamma SpA   (Italy)

^l Sigma Tau SpA   (Italy)

^m FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

ⁿ BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 FLUORO 3 HYDROXYPHENYL) N NAPHTHALEN 1 YL ACRYLAMIDE; ANILIDE; CALCIUM; CINNAMIC ACID DERIVATIVE; CINNAMIC ANILIDE; CYCLOPHILIN D; CYCLOSPORIN A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE INHIBITOR; PROTEIN INHIBITOR; THIOL; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CROSS LINKING; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; RABBIT; REPERFUSION INJURY;

1-NAPHTHYLAMINE; ACRYLAMIDES; ANILIDES; ANIMALS; CALCIUM; CINNAMATES; FEMALE; MALE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RABBITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903535395     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500547c     Document Type: Article

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