Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1834-1838

  Germain, Andrew R ^a   Carmody, Leigh C ^a   Nag, Partha P ^a   Morgan, Barbara ^a   Verplank, Lynn ^a   Fernandez, Cristina ^a   Donckele, Etienne ^a   Feng, Yuxiong ^b,c   Perez, Jose R ^a   Dandapani, Sivaraman ^a   Palmer, Michelle ^a   Lander, Eric S ^a,c   Gupta, Piyush B ^b,c   Schreiber, Stuart L ^a   Munoz, Benito ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Breast cancer; Cancer stem cells; Epithelial to mesenchymal transdifferentiation (EMT); Molecular Libraries Probe Production Center Network (MLPCN)

Indexed keywords

CINNAMIC ACID DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER STEM CELL; DRUG HYDROLYSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION;

AMIDES; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; NEOPLASTIC STEM CELLS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874655249     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.025     Document Type: Article

References (12)

1. L.V. Nguyen, R. Vanner, P. Dirks, and C.J. Eaves Nat. Rev. Cancer 12 2012 133 and references therein
2. S. Bao, Q. Wu, R.E. McLendon, Y. Hao, Q. Shi, A.B. Hjelmeland, M.W. Dewhirst, D.D. Bigner, and J.N. Rich Nature 444 2006 756
3. M. Diehn, R.W. Cho, N.A. Lobo, T. Kalisky, M.J. Dorie, A.N. Kulp, D. Qian, J.S. Lam, L.E. Ailles, and M. Wong Nature 458 2009 780
4. M. Diehn, and M.F. Clarke J. Natl. Cancer Inst. 98 2006 1755
5. C.E. Eyler, and J.N. Rich J. Clin. Oncol. 17 2008 2839
6. X. Li, M.T. Lewis, J. Huang, C. Gutierrez, C.K. Osborne, M.F. Wu, S.G. Hilsenbeck, A. Pavlick, X. Zhang, and G.C. Chamness J. Natl. Cancer Inst. 100 2008 672
7. S.A. Mani, W. Guo, M.J. Liao, E.N. Eaton, A. Ayyanan, A.Y. Zhou, M. Brooks, F. Reinhard, C.C. Zhang, M. Shipitsin, L.L. Campbell, K. Polyak, C. Brisken, J. Yang, and R.A. Weinberg Cell 133 2008 704
8. G. Dontu, W.M. Abdallah, J.M. Foley, K.W. Jackson, M.F. Clarke, M.J. Kawamura, and M.S. Wicha Genes Dev. 17 2003 1253
9. P.B. Gupta, T.T. Onder, G. Jiang, K. Tao, C. Kuperwasser, R.A. Weinberg, and E.S. Lander Cell 138 2009 645
10. L.C. Carmody, A.R. Germain, L. VerPlank, P.P. Nag, B. Munoz, J.R. Perez, and M.A. Palmer J. Biomol. Screen. 17 2012 1204
11. All data for this project can be found at: http://pubchem.ncbi.nlm.nih. gov/assay/assay.cgi?aid=2721.
12. A.R. Germain, L.C. Carmody, B. Morgan, C. Fernandez, E. Forbeck, T.A. Lewis, P.P. Nag, A. Ting, L. Verplank, F. Feng, J.R. Perez, S. Dandapani, M. Palmer, E.S. Lander, P.B. Gupta, S.L. Schreiber, and B. Munoz Bioorg. Med. Chem. Lett. 22 2012 3571