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Volumn 14, Issue 4, 2010, Pages 669-685

Adding Value to Liver (and Allograft) Biopsy Evaluation Using a Combination of Multiplex Quantum Dot Immunostaining, High-Resolution Whole-Slide Digital Imaging, and Automated Image Analysis

Author keywords

Automated image analysis; Digital pathology; Liver allograft pathology; Liver biopsy; Multiplex immunostaining

Indexed keywords

ANTIGEN BINDING; AUTOMATED IMAGE ANALYSIS; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL SURVIVAL; CHRONIC HEPATITIS; DIGITAL IMAGING; ENDOTHELIUM; HIGH RESOLUTION WHOLE SLIDE DIGITAL IMAGING; HISTOPATHOLOGY; HUMAN; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; LIVER GRAFT; MICROSCOPY; MULTIPLEX QUANTUM DOT IMMUNOSTAINING; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; REVIEW; SIGNAL TRANSDUCTION; STAINING; STELLATE CELL;

EID: 78049461402     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2010.07.004     Document Type: Review
Times cited : (28)

References (63)
  • 1
    • 69949104559 scopus 로고    scopus 로고
    • Late protocol liver biopsies in the liver allograft: a neglected investigation?
    • Mells G., Mann C., Hubscher S., et al. Late protocol liver biopsies in the liver allograft: a neglected investigation?. Liver Transpl 2009, 15:931-938.
    • (2009) Liver Transpl , vol.15 , pp. 931-938
    • Mells, G.1    Mann, C.2    Hubscher, S.3
  • 2
    • 49149114788 scopus 로고    scopus 로고
    • Protocol liver allograft biopsies
    • Mells G., Neuberger J. Protocol liver allograft biopsies. Transplantation 2008, 85:1686-1692.
    • (2008) Transplantation , vol.85 , pp. 1686-1692
    • Mells, G.1    Neuberger, J.2
  • 3
    • 28244444532 scopus 로고    scopus 로고
    • Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    • Muthukumar T., Dadhania D., Ding R., et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005, 353:2342-2351.
    • (2005) N Engl J Med , vol.353 , pp. 2342-2351
    • Muthukumar, T.1    Dadhania, D.2    Ding, R.3
  • 5
    • 65649147265 scopus 로고    scopus 로고
    • Molecular correlates of renal function in kidney transplant biopsies
    • Bunnag S., Einecke G., Reeve J., et al. Molecular correlates of renal function in kidney transplant biopsies. J Am Soc Nephrol 2009, 20:1149-1160.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1149-1160
    • Bunnag, S.1    Einecke, G.2    Reeve, J.3
  • 6
    • 48749084927 scopus 로고    scopus 로고
    • Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients
    • Martinez-Llordella M., Lozano J.J., Puig-Pey I., et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008, 118:2845-2857.
    • (2008) J Clin Invest , vol.118 , pp. 2845-2857
    • Martinez-Llordella, M.1    Lozano, J.J.2    Puig-Pey, I.3
  • 7
    • 33846252277 scopus 로고    scopus 로고
    • Multiparameter immune profiling of operational tolerance in liver transplantation
    • Martinez-Llordella M., Puig-Pey I., Orlando G., et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007, 7:309-319.
    • (2007) Am J Transplant , vol.7 , pp. 309-319
    • Martinez-Llordella, M.1    Puig-Pey, I.2    Orlando, G.3
  • 8
    • 67949117038 scopus 로고    scopus 로고
    • Can protocol biopsy better inform our choices in renal transplantation?
    • Rush D. Can protocol biopsy better inform our choices in renal transplantation?. Transplant Proc 2009, 41:S6-S8.
    • (2009) Transplant Proc , vol.41
    • Rush, D.1
  • 9
    • 66249122732 scopus 로고    scopus 로고
    • Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis
    • Schaub S., Nickerson P., Rush D., et al. Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis. Am J Transplant 2009, 9:1347-1353.
    • (2009) Am J Transplant , vol.9 , pp. 1347-1353
    • Schaub, S.1    Nickerson, P.2    Rush, D.3
  • 10
    • 34447642181 scopus 로고    scopus 로고
    • Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology
    • Schaub S., Mayr M., Honger G., et al. Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology. Transplantation 2007, 84:104-112.
    • (2007) Transplantation , vol.84 , pp. 104-112
    • Schaub, S.1    Mayr, M.2    Honger, G.3
  • 11
    • 67449089817 scopus 로고    scopus 로고
    • " Nature versus nurture" study of deceased-donor pairs in kidney transplantation
    • Louvar D.W., Li N., Snyder J., et al. " Nature versus nurture" study of deceased-donor pairs in kidney transplantation. J Am Soc Nephrol 2009, 20:1351-1358.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1351-1358
    • Louvar, D.W.1    Li, N.2    Snyder, J.3
  • 12
    • 57749083522 scopus 로고    scopus 로고
    • HLA-A amino acid polymorphism and delayed kidney allograft function
    • Kamoun M., Holmes J.H., Israni A.K., et al. HLA-A amino acid polymorphism and delayed kidney allograft function. Proc Natl Acad Sci U S A 2008, 105:18883-18888.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18883-18888
    • Kamoun, M.1    Holmes, J.H.2    Israni, A.K.3
  • 13
    • 47149083319 scopus 로고    scopus 로고
    • Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation
    • Israni A.K., Li N., Cizman B.B., et al. Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation. Am J Kidney Dis 2008, 52:331-339.
    • (2008) Am J Kidney Dis , vol.52 , pp. 331-339
    • Israni, A.K.1    Li, N.2    Cizman, B.B.3
  • 14
    • 0029039362 scopus 로고
    • Histologic grading and staging of chronic hepatitis
    • Ishak K., Baptista A., Bianchi L., et al. Histologic grading and staging of chronic hepatitis. J Hepatol 1995, 22:696-699.
    • (1995) J Hepatol , vol.22 , pp. 696-699
    • Ishak, K.1    Baptista, A.2    Bianchi, L.3
  • 15
    • 0028806153 scopus 로고
    • Chronic hepatitis. An update on terminology and reporting
    • Batts K.P., Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 1995, 19:1409-1417.
    • (1995) Am J Surg Pathol , vol.19 , pp. 1409-1417
    • Batts, K.P.1    Ludwig, J.2
  • 16
    • 0029778988 scopus 로고    scopus 로고
    • An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group
    • Bedossa P., Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996, 24:289-293.
    • (1996) Hepatology , vol.24 , pp. 289-293
    • Bedossa, P.1    Poynard, T.2
  • 17
    • 0037112889 scopus 로고    scopus 로고
    • Real-time monitoring of acute liver-allograft rejection using the Banff schema
    • Demetris A.J., Ruppert K., Dvorchik I., et al. Real-time monitoring of acute liver-allograft rejection using the Banff schema. Transplantation 2002, 74:1290-1296.
    • (2002) Transplantation , vol.74 , pp. 1290-1296
    • Demetris, A.J.1    Ruppert, K.2    Dvorchik, I.3
  • 18
    • 0033996572 scopus 로고    scopus 로고
    • Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel
    • Demetris A., Adams D., Bellamy C., et al. Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel. Hepatology 2000, 31:792-799.
    • (2000) Hepatology , vol.31 , pp. 792-799
    • Demetris, A.1    Adams, D.2    Bellamy, C.3
  • 19
    • 35348830483 scopus 로고    scopus 로고
    • Pathology and immunopathology of immunoglobulin G4-related sclerosing cholangitis: the latest addition to the sclerosing cholangitis family
    • Nakanuma Y., Zen Y. Pathology and immunopathology of immunoglobulin G4-related sclerosing cholangitis: the latest addition to the sclerosing cholangitis family. Hepatol Res 2007, 37(Suppl 3):S478-S486.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL 3
    • Nakanuma, Y.1    Zen, Y.2
  • 20
    • 59849121912 scopus 로고    scopus 로고
    • Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology
    • Bioulac-Sage P., Laumonier H., Rullier A., et al. Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology. Liver Int 2009, 29:459-465.
    • (2009) Liver Int , vol.29 , pp. 459-465
    • Bioulac-Sage, P.1    Laumonier, H.2    Rullier, A.3
  • 21
    • 61749103943 scopus 로고    scopus 로고
    • The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma
    • Di Tommaso L., Destro A., Seok J.Y., et al. The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J Hepatol 2009, 50:746-754.
    • (2009) J Hepatol , vol.50 , pp. 746-754
    • Di Tommaso, L.1    Destro, A.2    Seok, J.Y.3
  • 22
    • 35948984059 scopus 로고    scopus 로고
    • Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms
    • Kakar S., Gown A.M., Goodman Z.D., et al. Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms. Arch Pathol Lab Med 2007, 131:1648-1654.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1648-1654
    • Kakar, S.1    Gown, A.M.2    Goodman, Z.D.3
  • 23
    • 34250763945 scopus 로고    scopus 로고
    • Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
    • Bioulac-Sage P., Rebouissou S., Thomas C., et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007, 46:740-748.
    • (2007) Hepatology , vol.46 , pp. 740-748
    • Bioulac-Sage, P.1    Rebouissou, S.2    Thomas, C.3
  • 24
    • 33744784568 scopus 로고    scopus 로고
    • HepPar1, MOC-31, pCEA, mCEA and CD10 for distinguishing hepatocellular carcinoma vs. metastatic adenocarcinoma in liver fine needle aspirates
    • Wang L., Vuolo M., Suhrland M.J., et al. HepPar1, MOC-31, pCEA, mCEA and CD10 for distinguishing hepatocellular carcinoma vs. metastatic adenocarcinoma in liver fine needle aspirates. Acta Cytol 2006, 50:257-262.
    • (2006) Acta Cytol , vol.50 , pp. 257-262
    • Wang, L.1    Vuolo, M.2    Suhrland, M.J.3
  • 25
    • 0036904999 scopus 로고    scopus 로고
    • A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver
    • Morrison C., Marsh W., Frankel W.L. A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver. Mod Pathol 2002, 15:1279-1287.
    • (2002) Mod Pathol , vol.15 , pp. 1279-1287
    • Morrison, C.1    Marsh, W.2    Frankel, W.L.3
  • 26
    • 0030801433 scopus 로고    scopus 로고
    • Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors
    • Minervini M.I., Demetris A.J., Lee R.G., et al. Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors. Mod Pathol 1997, 10:686-692.
    • (1997) Mod Pathol , vol.10 , pp. 686-692
    • Minervini, M.I.1    Demetris, A.J.2    Lee, R.G.3
  • 27
    • 0034878014 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in native livers from patients treated with orthotopic liver transplantation: biologic and therapeutic implications
    • Kirimlioglu H., Dvorchick I., Ruppert K., et al. Hepatocellular carcinomas in native livers from patients treated with orthotopic liver transplantation: biologic and therapeutic implications. Hepatology 2001, 34:502-510.
    • (2001) Hepatology , vol.34 , pp. 502-510
    • Kirimlioglu, H.1    Dvorchick, I.2    Ruppert, K.3
  • 28
    • 33747080802 scopus 로고    scopus 로고
    • Liver biopsy interpretation for causes of late liver allograft dysfunction
    • Banff Working G., Demetris A.J., Adeyi O., et al. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology 2006, 44:489-501.
    • (2006) Hepatology , vol.44 , pp. 489-501
    • Banff Working, G.1    Demetris, A.J.2    Adeyi, O.3
  • 29
    • 65449173159 scopus 로고    scopus 로고
    • The perils and promise of high-dimensional biology
    • Therneau T. The perils and promise of high-dimensional biology. Hepatology 2009, 49:1061-1062.
    • (2009) Hepatology , vol.49 , pp. 1061-1062
    • Therneau, T.1
  • 30
    • 12444310253 scopus 로고    scopus 로고
    • Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allografts
    • Wu T., Cieply K., Nalesnik M.A., et al. Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allografts. Am J Transplant 2003, 3:1173-1181.
    • (2003) Am J Transplant , vol.3 , pp. 1173-1181
    • Wu, T.1    Cieply, K.2    Nalesnik, M.A.3
  • 31
    • 0027480021 scopus 로고
    • Practical suggestions for successful immunoenzyme double-staining experiments
    • van der Loos C.M., Becker A.E., van den Oord J.J. Practical suggestions for successful immunoenzyme double-staining experiments. Histochem J 1993, 25:1-13.
    • (1993) Histochem J , vol.25 , pp. 1-13
    • van der Loos, C.M.1    Becker, A.E.2    van den Oord, J.J.3
  • 32
    • 0025649091 scopus 로고
    • A quantitative analysis of T lymphocyte populations in human liver allografts undergoing rejection: the use of monoclonal antibodies and double immunolabeling
    • McCaughan G.W., Davies J.S., Waugh J.A., et al. A quantitative analysis of T lymphocyte populations in human liver allografts undergoing rejection: the use of monoclonal antibodies and double immunolabeling. Hepatology 1990, 12:1305-1313.
    • (1990) Hepatology , vol.12 , pp. 1305-1313
    • McCaughan, G.W.1    Davies, J.S.2    Waugh, J.A.3
  • 33
    • 0025088960 scopus 로고
    • Double and triple immunocytochemical labelling at the light microscope level in histopathology
    • Krenacs T., Krenacs L., Bozoky B., et al. Double and triple immunocytochemical labelling at the light microscope level in histopathology. Histochem J 1990, 22:530-536.
    • (1990) Histochem J , vol.22 , pp. 530-536
    • Krenacs, T.1    Krenacs, L.2    Bozoky, B.3
  • 34
    • 0036320559 scopus 로고    scopus 로고
    • Immunohistochemical double-staining of renal allograft tissue: critical assessment of three different protocols
    • Waiser J., Schwaar S., Bohler T., et al. Immunohistochemical double-staining of renal allograft tissue: critical assessment of three different protocols. Virchows Arch 2002, 440:648-654.
    • (2002) Virchows Arch , vol.440 , pp. 648-654
    • Waiser, J.1    Schwaar, S.2    Bohler, T.3
  • 35
    • 70449732855 scopus 로고    scopus 로고
    • Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma
    • Wang M., Xue L., Cao Q., et al. Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma. Neoplasma 2009, 56:533-541.
    • (2009) Neoplasma , vol.56 , pp. 533-541
    • Wang, M.1    Xue, L.2    Cao, Q.3
  • 36
    • 68949091981 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis
    • Yang J.C., Teng C.F., Wu H.C., et al. Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. Hepatology 2009, 49:1962-1971.
    • (2009) Hepatology , vol.49 , pp. 1962-1971
    • Yang, J.C.1    Teng, C.F.2    Wu, H.C.3
  • 37
    • 58149159555 scopus 로고    scopus 로고
    • High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans
    • Suzuki S., Takeshita K., Asamoto M., et al. High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans. Toxicology 2009, 255:160-170.
    • (2009) Toxicology , vol.255 , pp. 160-170
    • Suzuki, S.1    Takeshita, K.2    Asamoto, M.3
  • 38
    • 11244335567 scopus 로고    scopus 로고
    • Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy
    • Sirica A.E. Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology 2005, 41:5-15.
    • (2005) Hepatology , vol.41 , pp. 5-15
    • Sirica, A.E.1
  • 39
    • 57349101055 scopus 로고    scopus 로고
    • Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective
    • Demetris A.J., Lunz J.G., Randhawa P., et al. Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. Transpl Int 2009, 22:120-141.
    • (2009) Transpl Int , vol.22 , pp. 120-141
    • Demetris, A.J.1    Lunz, J.G.2    Randhawa, P.3
  • 40
    • 33646558290 scopus 로고    scopus 로고
    • Progressive histological damage in liver allografts following pediatric liver transplantation
    • Evans H.M., Kelly D.A., McKiernan P.J., et al. Progressive histological damage in liver allografts following pediatric liver transplantation. Hepatology 2006, 43:1109-1117.
    • (2006) Hepatology , vol.43 , pp. 1109-1117
    • Evans, H.M.1    Kelly, D.A.2    McKiernan, P.J.3
  • 41
    • 0031927736 scopus 로고    scopus 로고
    • Tolerance and latent cellular rejection in long-term liver transplant recipients
    • Wong T., Nouri-Aria K.T., Devlin J., et al. Tolerance and latent cellular rejection in long-term liver transplant recipients. Hepatology 1998, 28:443-449.
    • (1998) Hepatology , vol.28 , pp. 443-449
    • Wong, T.1    Nouri-Aria, K.T.2    Devlin, J.3
  • 42
    • 65649106140 scopus 로고    scopus 로고
    • Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation
    • Yoshitomi M., Koshiba T., Haga H., et al. Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation. Transplantation 2009, 87:606-614.
    • (2009) Transplantation , vol.87 , pp. 606-614
    • Yoshitomi, M.1    Koshiba, T.2    Haga, H.3
  • 43
    • 33947210002 scopus 로고    scopus 로고
    • Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance
    • Xu Q., Lee J., Jankowska-Gan E., et al. Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol 2007, 178:3983-3995.
    • (2007) J Immunol , vol.178 , pp. 3983-3995
    • Xu, Q.1    Lee, J.2    Jankowska-Gan, E.3
  • 44
    • 34248679904 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects
    • Kang S.M., Tang Q., Bluestone J.A. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 2007, 7:1457-1463.
    • (2007) Am J Transplant , vol.7 , pp. 1457-1463
    • Kang, S.M.1    Tang, Q.2    Bluestone, J.A.3
  • 45
    • 77951634577 scopus 로고    scopus 로고
    • Cell type-specific gene expression differences in complex tissues
    • Shen-Orr S.S., Tibshirani R., Khatri P., et al. Cell type-specific gene expression differences in complex tissues. Nat Methods 2010, 7(4):287-289.
    • (2010) Nat Methods , vol.7 , Issue.4 , pp. 287-289
    • Shen-Orr, S.S.1    Tibshirani, R.2    Khatri, P.3
  • 46
    • 55249101753 scopus 로고    scopus 로고
    • Quantum dots light up pathology
    • Tholouli E., Sweeney E., Barrow E., et al. Quantum dots light up pathology. J Pathol 2008, 216:275-285.
    • (2008) J Pathol , vol.216 , pp. 275-285
    • Tholouli, E.1    Sweeney, E.2    Barrow, E.3
  • 47
    • 48349083364 scopus 로고    scopus 로고
    • Quantitative multiplexed quantum dot immunohistochemistry
    • Sweeney E., Ward T.H., Gray N., et al. Quantitative multiplexed quantum dot immunohistochemistry. Biochem Biophys Res Commun 2008, 374:181-186.
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 181-186
    • Sweeney, E.1    Ward, T.H.2    Gray, N.3
  • 48
    • 33747620875 scopus 로고    scopus 로고
    • Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots
    • Fountaine T.J., Wincovitch S.M., Geho D.H., et al. Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots. Mod Pathol 2006, 19:1181-1191.
    • (2006) Mod Pathol , vol.19 , pp. 1181-1191
    • Fountaine, T.J.1    Wincovitch, S.M.2    Geho, D.H.3
  • 49
    • 41049096731 scopus 로고    scopus 로고
    • Associative image analysis: a method for automated quantification of 3D multi-parameter images of brain tissue
    • Bjornsson C.S., Lin G., Al-Kofahi Y., et al. Associative image analysis: a method for automated quantification of 3D multi-parameter images of brain tissue. J Neurosci Methods 2008, 170:165-178.
    • (2008) J Neurosci Methods , vol.170 , pp. 165-178
    • Bjornsson, C.S.1    Lin, G.2    Al-Kofahi, Y.3
  • 50
    • 78049483533 scopus 로고    scopus 로고
    • Combining H&E, multiplex quantum dot immunostaining, and whole slide imaging for liver biopsy evaluation
    • [abstract 1234]
    • Isse K., Lunz Iii J.G., Specht M.S., et al. Combining H&E, multiplex quantum dot immunostaining, and whole slide imaging for liver biopsy evaluation. Hepatology 2009, 50(Suppl). [abstract 1234].
    • (2009) Hepatology , vol.50 , Issue.SUPPL
    • Isse, K.1    Lunz Iii, J.G.2    Specht, M.S.3
  • 51
    • 77950608746 scopus 로고    scopus 로고
    • Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans
    • Isse K., Specht S.M., Lunz J.G., et al. Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. Hepatology 2009, 51:869-880.
    • (2009) Hepatology , vol.51 , pp. 869-880
    • Isse, K.1    Specht, S.M.2    Lunz, J.G.3
  • 52
    • 73349107801 scopus 로고    scopus 로고
    • Histologic graft assessment after clinical islet transplantation
    • Toso C., Isse K., Demetris A.J., et al. Histologic graft assessment after clinical islet transplantation. Transplantation 2009, 88:1286-1293.
    • (2009) Transplantation , vol.88 , pp. 1286-1293
    • Toso, C.1    Isse, K.2    Demetris, A.J.3
  • 53
    • 33846910502 scopus 로고    scopus 로고
    • Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    • Koshiba T., Li Y., Takemura M., et al. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transpl Immunol 2007, 17:94-97.
    • (2007) Transpl Immunol , vol.17 , pp. 94-97
    • Koshiba, T.1    Li, Y.2    Takemura, M.3
  • 54
    • 77950245872 scopus 로고    scopus 로고
    • Improved automatic detection and segmentation of cell nuclei in histopathology images
    • Al-Kofahi Y., Lassoued W., Lee W., et al. Improved automatic detection and segmentation of cell nuclei in histopathology images. IEEE Trans Biomed Eng 2009, 57(4):841-852.
    • (2009) IEEE Trans Biomed Eng , vol.57 , Issue.4 , pp. 841-852
    • Al-Kofahi, Y.1    Lassoued, W.2    Lee, W.3
  • 55
    • 33745439024 scopus 로고    scopus 로고
    • Phosphorylated S6 ribosomal protein: a novel biomarker of antibody-mediated rejection in heart allografts
    • Lepin E.J., Zhang Q., Zhang X., et al. Phosphorylated S6 ribosomal protein: a novel biomarker of antibody-mediated rejection in heart allografts. Am J Transplant 2006, 6:1560-1571.
    • (2006) Am J Transplant , vol.6 , pp. 1560-1571
    • Lepin, E.J.1    Zhang, Q.2    Zhang, X.3
  • 56
    • 67650501644 scopus 로고    scopus 로고
    • Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future
    • Weinstein R.S., Graham A.R., Richter L.C., et al. Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 2009, 40:1057-1069.
    • (2009) Hum Pathol , vol.40 , pp. 1057-1069
    • Weinstein, R.S.1    Graham, A.R.2    Richter, L.C.3
  • 57
    • 71749098726 scopus 로고    scopus 로고
    • Digital slides: present status of a tool for consultation, teaching, and quality control in pathology
    • Rocha R., Vassallo J., Soares F., et al. Digital slides: present status of a tool for consultation, teaching, and quality control in pathology. Pathol Res Pract 2009, 205:735-741.
    • (2009) Pathol Res Pract , vol.205 , pp. 735-741
    • Rocha, R.1    Vassallo, J.2    Soares, F.3
  • 58
    • 58349103359 scopus 로고    scopus 로고
    • Impact of digital image manipulation in cytology
    • Pinco J., Goulart R.A., Otis C.N., et al. Impact of digital image manipulation in cytology. Arch Pathol Lab Med 2009, 133:57-61.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 57-61
    • Pinco, J.1    Goulart, R.A.2    Otis, C.N.3
  • 59
    • 57749085509 scopus 로고    scopus 로고
    • Can histology and pathology be taught without microscopes? The advantages and disadvantages of virtual histology
    • Coleman R. Can histology and pathology be taught without microscopes? The advantages and disadvantages of virtual histology. Acta Histochem 2009, 111:1-4.
    • (2009) Acta Histochem , vol.111 , pp. 1-4
    • Coleman, R.1
  • 60
    • 64849083706 scopus 로고    scopus 로고
    • From the incandescent light bulb to digital pathology: corporate innovation as an engine for change
    • Montalto M.C., Cartwright G. From the incandescent light bulb to digital pathology: corporate innovation as an engine for change. Arch Pathol Lab Med 2009, 133:550-552.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 550-552
    • Montalto, M.C.1    Cartwright, G.2
  • 61
    • 67650499944 scopus 로고    scopus 로고
    • Automated cellular imaging system III for assessing HER2 status in breast cancer specimens: development of a standardized scoring method that correlates with FISH
    • Minot D.M., Kipp B.R., Root R.M., et al. Automated cellular imaging system III for assessing HER2 status in breast cancer specimens: development of a standardized scoring method that correlates with FISH. Am J Clin Pathol 2009, 132:133-138.
    • (2009) Am J Clin Pathol , vol.132 , pp. 133-138
    • Minot, D.M.1    Kipp, B.R.2    Root, R.M.3
  • 62
    • 69749092500 scopus 로고    scopus 로고
    • Standardization of HER2 immunohistochemistry in breast cancer by automated quantitative analysis
    • Gustavson M.D., Bourke-Martin B., Reilly D., et al. Standardization of HER2 immunohistochemistry in breast cancer by automated quantitative analysis. Arch Pathol Lab Med 2009, 133:1413-1419.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 1413-1419
    • Gustavson, M.D.1    Bourke-Martin, B.2    Reilly, D.3
  • 63
    • 34047236016 scopus 로고    scopus 로고
    • Antibody-mediated renal allograft rejection: diagnosis and pathogenesis
    • Colvin R.B. Antibody-mediated renal allograft rejection: diagnosis and pathogenesis. J Am Soc Nephrol 2007, 18:1046-1056.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1046-1056
    • Colvin, R.B.1


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