Recombination Accelerates Adaptation on a Large-Scale Empirical Fitness Landscape in HIV-1

PLoS Genetics

Volumn 10, Issue 6, 2014, Pages

  Moradigaravand, Danesh ^a   Kouyos, Roger ^b   Hinkley, Trevor ^c   Haddad, Mojgan ^d   Petropoulos, Christos J ^d   Engelstädter, Jan ^e   Bonhoeffer, Sebastian ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d MONOGRAM BIOSCIENCES   (United States)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ADAPTATION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EPISTASIS; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC DISTANCE; GENETIC VARIABILITY; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LARGE SCALE EMPIRICAL FITNESS LANDSCAPE; MOLECULAR EVOLUTION; MUTATION RATE; NATURAL SELECTION; NONHUMAN; POPULATION GENETIC PARAMETERS; POPULATION SIZE; RECOMBINATION RATE; VIRUS RECOMBINATION; BIOLOGICAL MODEL; COMPUTER SIMULATION; EVOLUTION; GENETIC RECOMBINATION; GENETIC SELECTION; GENETICS; POPULATION GENETICS; REPRODUCTIVE FITNESS;

ADAPTATION, PHYSIOLOGICAL; BIOLOGICAL EVOLUTION; COMPUTER SIMULATION; GENETIC FITNESS; GENETICS, POPULATION; HIV-1; MODELS, GENETIC; MUTATION RATE; RECOMBINATION, GENETIC; SELECTION, GENETIC;

EID: 84903486965     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004439     Document Type: Article

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