Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density

Biomaterials

Volumn 35, Issue 27, 2014, Pages 8015-8027

  Tang, Zhaomin ^a   Li, Dan ^a   Sun, Huili ^a   Guo, Xing ^a   Chen, Yuping ^a   Zhou, Shaobing ^a  

^a SOUTHWEST JIAOTONG UNIVERSITY   (China)

Author keywords

Active targeting; Drug delivery; Folate mediated; Magnetic nanoparticles; Multivalent linkage

Indexed keywords

ATOMIC EMISSION SPECTROSCOPY; CELLS; CYTOLOGY; DRUG DELIVERY; INDUCTIVELY COUPLED PLASMA; MOLECULAR BIOLOGY; NANOPARTICLES; ONCOLOGY; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

ACTIVE TARGETING; FOLATE-MEDIATED; INDUCTIVELY COUPLED PLASMA ATOMIC EMISSION SPECTROSCOPY; IRON OXIDE NANOPARTICLE; MAGNETIC NANO-PARTICLES; MAGNETIC NANOPARTI CLES (MNPS); MULTIVALENT LINKAGE; SPECIFIC INTERACTION;

LIGANDS;

DOXORUBICIN; FERRIC FERROCYANIDE; FOLATE RECEPTOR; FOLIC ACID; LIGAND; NANOCARRIER; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; DRUG CARRIER; IRON; MAGNETITE NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC EMISSION SPECTROMETRY; CELL GROWTH; CONTROLLED STUDY; DENSITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TARGETING; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STAINING; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL; ANIMAL; BAGG ALBINO MOUSE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; HELA CELL LINE; METABOLISM; PATHOLOGY; SPECTROFLUOROMETRY; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ANIMALS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; FOLIC ACID; HELA CELLS; HUMANS; IRON; LIGANDS; MACROPHAGES; MAGNETITE NANOPARTICLES; MALE; MICE, INBRED BALB C; SPECTROMETRY, FLUORESCENCE; STAINING AND LABELING; TISSUE DISTRIBUTION;

EID: 84903482176     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.05.091     Document Type: Article

References (65)

1. Liu J.N., Bu W.B., Pan L.M., Shi J.L. NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica. Angew Chem Int Ed 2013, 52:4375-4379.
2. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
3. Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303:1818.
4. Adair J.H., Parette M.P., Altinoǧlu E.I., Kester M. Nanoparticulate alternatives for drug delivery. ACS Nano 2010, 4:4967-4970.
5. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polym Sci 2007, 32:962-990.
6. Gottesman M.M., Fojo T., Bates S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2002, 2:48-58.
7. Johannes R., Aaron L., Sean O.H., Daniel O., Timothy O.B., Richard M.D., et al. Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury. Biomaterials 2013, 34:1987-1994.
8. Yang H.W., Liu H.L., Li M.L., Hsi I.W., Fan C.T., Huang C.Y., et al. Magnetic gold-nanorod/PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy. Biomaterials 2013, 34:5651-5660.
9. 2 for simultaneous tumor cell targeting and stimulus-induced drug release. Adv Mater 2013, 25:3485-3489.
10. Lee G.Y., Qian W.P., Wang L.Y., Wang Y.Q.A., Staley C.A., Satpathy M., et al. Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer. ACS Nano 2013, 7:2078-2089.
11. Borase T., Ninjbadgar T., Kapetanakis A., Roche A., Robert O.C., Kerskens C., et al. Stable aqueous dispersions of glycopeptide-grafted selectably functionalized magnetic nanoparticles. Angew Chem Int Ed 2013, 52:3164-3167.
12. Shah B., Yin P.T., Ghoshal S., Lee K.B. Multimodal magnetic core-shell nanoparticles for effective stem-cell differentiation and imaging. Angew Chem Int Ed 2013, 125:6310-6315.
13. Zhu L.J., Wang D.L., Wei X., Zhu X.Y., Li J.Q., Tu C.L., et al. Multifunctional pH-sensitive superparamagnetic iron-oxide nanocomposites for targeted drug delivery and MR imaging. JControl Release 2013, 169:228-238.
14. Kokuryo D., Anraku Y., Kishimura A., Tanaka S., Kano M.R., Kershaw J., et al. SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles. JControl Release 2013, 169:220-227.
15. Huang C., Tang Z.M., Zhou Y.B., Zhou X.F., Jin Y., Li D., et al. Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy. Int J Pharm 2012, 429:113-122.
16. Ashley C.E., Carnes E.C., Phillips G.K., Padilla D., Durfee P.N., Brown P.A., et al. The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nat Mater 2011, 10:389-397.
17. Chen C., Ke J.Y., Zhou X.D., Yi W., Brunzelle J.S., Li J., et al. Structural basis for molecular recognition of folic acid by folate receptors. Nature 2013, 500:486-489.
18. Wei X., Philip S.L. Folate-targeted therapies for cancer. JMed Chem 2010, 53:6811-6824.
19. Sega E.I., Low P.S. Tumor detection using folate receptor-targeted imaging agents. Cancer Metastasis Rev 2008, 27:655-664.
20. Nasongkla N., Shuai X.T., Ai H., Weinberg B.D., Pink J., Boothman D.A., et al. cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem 2004, 116:6483-6487.
21. Salvati A., Pitek A.S., Monopoli M.P., Prapainop K., Bombelli F.B., Hristow D.R., et al. Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat Nanotechnol 2013, 8:137-143.
22. Dinaue N., Balthasar S., Weber C., Kreuter J., Langer K., Briesen H.V. Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes. Biomaterials 2005, 26:5895-5906.
23. Lee Y., Lee H., Kim Y.B., Kim J., Hyeon T., Park H.W., et al. Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging. Adv Mater 2008, 20:4154-4157.
24. Allen T.M. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002, 2:750-773.
25. Cheng Z.L., Zaki A.A., Hui J.Z., Muzykantov V.R., Andrew T. Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science 2012, 338:903-910.
26. Du P.C., Zeng J., Mu B., Liu P. Biocompatible magnetic and molecular dual-targeting polyelectrolyte hybrid hollow microspheres for controlled drug release. Mol Pharm 2013, 10:1705-1715.
27. Lin J.J., Chen J.S., Huang S.J., Ko J.H., Wang Y.M., Chen T.L., et al. Folic acid-pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications. Biomaterials 2009, 30:5114-5124.
28. Huang C., Neoh K.G., Kang E.T., Shuter B. Surface modified superparamagnetic iron oxide nanoparticles for high efficiency folate-receptor targeting with low uptake by macrophages. JMater Chem 2011, 21:16094-16102.
29. Landmark K.J., DiMaggio S., Ward J., Kelly C., Vogt S.H., Kotlyar A., et al. Synthesis, characterization and invitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugated dendrimers. ACS Nano 2008, 2:773-783.
30. Li J.C., Zheng L.F., Cai H.D., Sun W.J., Shen M.W., Zhang G.X., et al. Polyethyleneimine-mediated synthesis of folic acid-targeted iron oxide nanoparticles for invivo tumor MR imaging. Biomaterials 2013, 34:8382-8392.
31. Mohapatra S., Mallick S.K., Maiti T.K., Ghosh S.K., Pramanik P. Synthesis of highly stable folic acid conjugated magnetite nanoparticles for targeting cancer cells. Nanotechnology 2007, 18:385102.
32. Liong M., Lu J., Kovochich M., Xia T., Ruehm S.G., Nel A.E., et al. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2008, 2:889-896.
33. Low P.S., Kularatne S.A. Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol 2009, 13:256-262.
34. Sudimack J., Lee R.J. Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev 2000, 41:147-162.
35. Leamon C.P., Reddy J.A. Folate-targeted chemotherapy. Adv Drug Deliv Rev 2004, 56:1127-1141.
36. Yang K.K., Kong M., Wei Y.N., Liu Y., Cheng X.J., Li J., et al. Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery. JMater Sci 2013, 48:1717-1728.
37. Gabizon A., Horowitz A.T., Goren D., Tzemach D., Shmeeda H., Zalipsky S. Invivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice. Clin Cancer Res 2013, 9:6551-6559.
38. Gabizon A., Shmeeda H., Horowitz A.T., Zalipsky S. Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid-PEG conjugates. Adv Drug Deliv Rev 2004, 56:1177-1192.
39. Wang W.W., Chen D., Gong F., Miao X.M., Shuai X.T. Design of multifunctional micelle for tumor-targeted cellular drug release and fluorescent imaging. Adv Mater 2012, 24:115-120.
40. Chen D., Cao N., Chen J.F., Yu X.S., Shuai X.T. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials 2012, 33:1170-1179.
41. Zheng G., Chen J., Li H., Jerry D.G. Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents. PNAS 2005, 102:17757-17762.
42. Liu R., Li D., He B., Xu X.H., Sheng M.M., Lai Y.S., et al. Anti-tumor drug delivery of pH-sensitive poly(ethylene glycol)-poly(L-histidine-)-poly(L-lactide) nanoparticles. JControl Release 2011, 152:49-56.
43. Luo K., Li C.X., Li L., She W.C., Wang G., Gu Z.W. Arginine functionalized peptide dendrimers as potential gene delivery vehicles. Biomaterials 2012, 33:4917-4927.
44. Patri A.K., Kukowska-Latallo J.F., Baker J.R. Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Adv Drug Deliv Rev 2005, 57:2203-2214.
45. Lu Y.J., Low P.S. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 2002, 54:675-693.
46. Nikki P., Mary J.T., Elaine W., Jeffrey D.W., Philip S.L., Christopher P.L. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005, 338:284-293.
47. Saul J.M., Annapragada A., Natarajan J.V., Bellamkonda R.V. Controlled targeting of liposomal doxorubicin via the folate receptor invitro. JControl Release 2003, 92:49-67.
48. Cao W.Q., Zhou J., Mann A., Wang Y., Zhu L. Folate-functionalized unimolecular micelles based on a degradable amphiphilic dendrimer-like star polymer for cancer cell-targeted drug delivery. Biomacromolecules 2011, 12:2697-2707.
49. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics. JControl Release 2000, 65:271-284.
50. 4 nanoparticles. JBiomed Mater Res A 2007, 80:333-341.
51. Huang C., Zhou Y.B., Jin Y., Zhou X.F., Tang Z.M., Zhou S.B., et al. Preparation and characterization of temperature-responsive and magnetic nanomicelles. JMater Chem 2011, 21:5660-5670.
52. Chen S., Zhang X.Z., Cheng S.X., Zhuo R.X., Gu Z.W. Functionalized amphiphilic hyperbranched polymers for targeted drug delivery. Biomacromolecules 2008, 9:2578-2585.
53. Wadajkar A.S., Menon J.U., Tsai Y.S., Gore C., Dobin T., Dobin T., et al. Prostate cancer-specific thermo-responsive polymer-coated iron oxide nanoparticles. Biomaterials 2013, 34:3618-3625.
54. Setua S., Menon D., Asok A., Nair S., Koyakutty M. Folate receptor targeted, rare-earth oxide nanocrystals for bi-modal fluorescence and magnetic imaging of cancer cells. Biomaterials 2012, 31:714-729.
55. Basak R., Bandyopadhyay R. Encapsulation of hydrophobic drugs in Pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH. Langmuir 2013, 29:4350-4356.
56. Zhang W., Shi Y., Chen Y.Z., Ye J., Sha X.Y., Fang X.L. Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors. Biomaterials 2011, 32:2894-2906.
57. Wang F.H., Chen Y.X., Zhang D.R., Zhang Q., Zheng D.D., Hao L.L., et al. Folate-mediated targeted and cellular delivery of paclitaxel using a novel deoxycholic acid-o-carboxymethylated chitosan-folic acid micelles. Int J Med 2012, 7:325-337.
58. Wang J., Yang G., Guo X., Tang Z.M., Zhong Z.D., Zhou S.B. Redox-responsive polyanhydride micelles for cancer therapy. Biomaterials 2014, 35:3080-3090.
59. Hadjipanayis C.G., Bonder M.J., Balakrishnan S., Wang X.X., Mao H., Hadjipanayis G.C. Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia. Small 2008, 4:1925-1929.
60. Yang H.W., Liu H.L., Li M.L., Hsi I.W., Fan C.T., Huang C.Y., et al. Magnetic gold-nanorod/PNIPAAmMA nanomicelles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy. Biomaterials 2013, 34:5651-5660.
61. Ge J., Hu Y.X., Biasini M., Beyermann W.P., Yin Y.D. Superparamagnetic magnetite colloidal nanocrystal clusters. Angew Chem Int Ed 2007, 46:4342-4345.
62. Huang C., Neoh K.G., Kang E.T., Shuter B. Surface modified superparamagnetic iron oxide nanomicelles (SPIONs) for high efficiency folate-receptor targeting with low uptake by macrophages. JMater Chem 2011, 21:16094-16102.
63. Shubayev V.I., Pisanic T.R., Jin S.H. Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev 2009, 61:467-477.
64. Guo X., Shi C.L., Wang J., Di S.B. Zhou SB. pH-triggered intracellular release from actively targeting polymer micelles. Biomaterials 2013, 34:4544-4554.
65. Hieu V.Q., Mi K.Y., Hwan J.J., Hwa J.L., Muthunarayanan M., Joon H.R., et al. Targeted delivery of mannan-coated superparamagnetic iron oxide nanoparticles to antigen-presenting cells for magnetic resonance-based diagnosis of metastatic lymph nodes invivo. Acta Biomater 2011, 7:3935-3945.