Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid micelles

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 325-337

  Wang, Feihu ^a   Chen, Yuxuan ^b   Zhang, Dianrui ^a   Zhang, Qiang ^c   Zheng, Dandan ^a   Hao, Leilei ^a   Liu, Yue ^a   Duan, Cunxian ^a   Jia, Lejiao ^a   Liu, Guangpu ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shenzhou Hospital   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Paclitaxel, Folate, Polymeric Micelles, Targeted Delivery

Indexed keywords

CHITOSAN; DEOXYCHOLIC ACID; FOLATE RECEPTOR; FOLIC ACID; PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG RELEASE; ENDOCYTOSIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTERNALIZATION; MICELLE; NANOENCAPSULATION; PHYSICAL CHEMISTRY; CANCER CELL DESTRUCTION; CELL DEATH; CELL STRAIN MCF 7; CELL TRANSPORT; CONCENTRATION RESPONSE; DRUG TARGETING; ENCAPSULATION; PARTICLE SIZE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; UPREGULATION; ZETA POTENTIAL;

ABSORBABLE IMPLANTS; BREAST NEOPLASMS; CELL MEMBRANE; CELL NUCLEUS; CHITOSAN; DRUG CARRIERS; FEMALE; FOLIC ACID; HUMANS; MICELLES; MICROSCOPY, FLUORESCENCE; PACLITAXEL; RHODAMINES; SOLUBILITY; TUMOR CELLS, CULTURED;

EID: 84863014128     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kim SC, Kim DW, Shim YH, et al. In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and effcacy. J Control Release. 2001;72:191-202.
2. Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J Pharm. 2002;235:179-192.
3. Weiss RB, Donehower RC, Wiernik PH. Hypersensitivity reactions from Taxol. J Clin Oncol. 1990;8:1263-1268.
4. Lee SC, Kim C, Kwon IC, Chung H, Jeong S Y. Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(epsilon-caprolactone) copolymer as a carrier for paclitaxel. J Control Release. 2003;89:437-446.
5. Chen LY, Du YM, Tian ZG, Sun LP. Effect of the degree of deacetyla-tion and the substitution of carboxymethyl chitosan on its aggregation behavior. J Polym Sci Part B Pol Phys. 2005;43:296-305.
6. Chen XG, Park HJ. Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions. Carbohyd Polym. 2003;53:355-359.
7. Liu X F, Guan YL, Yang DZ, Li Z, Ya o KD. Antibacterial action of chitosan and carboxymethylated chitosan. J Appl Polym Sci. 2001;79:1324-1335.
8. Han X, Liu J, Liu M, et al. 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: Preparation and evaluation in vitro. Int J Pharm. 2009;372:125-131.
9. Liu SQ, Wiradharma N, Gao SJ, Tong Y W, Yang YY. Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs. Biomaterials. 2007;28:1423-1433.
10. Lu Y, Low PS. Immunotherapy of folate receptor-expressing tumors: Review of recent advances and future prospects. J Control Release. 2003;91:17-29.
11. Zhang Y, Kohler N, Zhang M. Surface modifcation of superpara-magnetic magnetite nanoparticles and their intracellular uptake. Biomaterials. 2003;23:1553-1561.
12. Chan P, Kurisawa M, Chung JE, Yang Y Y. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials. 2007;28:540-549.
13. Park EK, Lee SB, Lee YM. Preparation and characterization of meth-oxy poly(ethylene glycol)/poly(e-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specifc folate-mediated targeting of anticancer drugs. Biomaterials. 2005;26:1053-1061.
14. Wang S, Luo J, Lantrip DA, et al. Design and synthesis of [111In] DTPA-folate for use as tumor-targeted radiopharmaceutical. Bio conjug Chem. 1997;8:673-679.
15. Lee ES, Na K, Bae YH. Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release. 2003;91:103-113.
16. Mansouri S, Cuie Y, Winnik F, Shi Q, Lavigne P. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials. 2006;27:2060-2065.
17. Oyewumi MO, Yokel RA, Jay M, Coakley T, Mumper RJ. Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. J Control Release. 2004;95:613-626.
18. Zhao HZ, Yue L, Lanry Y. Selectivity of folate conjugated polymer micelles against different tumor cells. Int J Pharm. 2008;349:256-268.
19. Wang FH, Zhang DR, Duan CX, et al. Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan- folic acid conjugates and self-aggregates. Carbohyd Polym. 2011;84: 1192-1200.
20. Zhang C, Qing P, Zhang H. Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system. Colloids Surf B Biointerfaces. 2004;39:69-75.
21. Seow WY, Xue JM, Yang YY. Targeted and intracellular delivery of paclitaxel using multi-functional polymeric micelles. Biomaterials. 2007;28:1730-1740.
22. Mahmud A, Xiong XB, Aliabadi HM, Lavasanifar A. Polymeric micelles for drug targeting. J Drug Target. 2007;15:553-584.
23. Kim K, Kwon S, Hyung PJ, Chung H, Young JS. Physicochemical characteristics of self-assembled nanoparticles based on glycol chitosan bearing 5β-cholanic acid. Langmuir. 2003;19:10188-10193.
24. Müller RH, Jacobs C. Buparvaquone mucoadhesive nanosuspension: Preparation, optimisation and long-term stability. Int J Pharm. 2002;237:151-161.
25. Raghunand N, He X, van Sluis R, et al. Enhancement of chemotherapy by manipulation of tumor pH. Br J Cancer. 1999;80:1005-1011.
26. Lee ES, Na K, Bae YH. Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. J Control Release. 2005;103:405-418.
27. Park K. All nanocarriers are created equal. J Control Release. 2008;130:139.
28. Wang J, He FT, Tzang CH, et al. Differential gene expression profles in paclitaxel-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells. Acta Pharmacol. 2005;40:1099-1104.