MicroRNA-338-3p regulates osteogenic differentiation of mouse bone marrow stromal stem cells by targeting Runx2 and Fgfr2

Journal of Cellular Physiology

Volumn 229, Issue 10, 2014, Pages 1494-1502

  Liu, Huan ^a   Sun, Qin ^a   Wan, Chunyan ^a   Li, Lu ^a   Zhang, Lu ^a   Chen, Zhi ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MICRORNA; MICRORNA 338 3P; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; BONE DEVELOPMENT; BONE MARROW CELL; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; IN VITRO STUDY; LUCIFERASE ASSAY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN TARGETING; STROMA CELL; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; MICRORNAS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84903470443     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24591     Document Type: Article

References (30)

1. Bartel DP. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297.
2. D'Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I. 1999. Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development (Cambridge, England) 126:2911-2920.
3. Gangaraju VK, Lin H. 2009. MicroRNAs: Key regulators of stem cells. Nat Rev Mol Cell Biol 10:116-125.
4. Huang L, Teng XY, Cheng YY, Lee KM, Kumta SM. 2004. Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone. Bone 34:393-401.
5. Jia J, Tian Q, Ling S, Liu Y, Yang S, Shao Z. 2013. MiR-145 suppresses osteogenic differentiation by targeting Sp7. FEBS Lett 587:3027-3031.
6. Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M. 2001. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 2:165-171.
7. Katoh Y, Katoh M. 2009. FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review). Int J Mol Med 23:307-311.
8. Komori T. 2010. Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res 339:189-195.
9. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
10. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. 2003. Prediction of mammalian microRNA targets. Cell 115:787-798.
11. Li H, Xie H, Liu W, Hu R, Huang B, Tan YF, Xu K, Sheng ZF, Zhou HD, Wu XP, Luo XH. 2009. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Investig 119:3666-3677.
12. Liao L, Yang X, Su X, Hu C, Zhu X, Yang N, Chen X, Shi S, Shi S, Jin Y. 2013. Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow. Cell Death Dis 4:e600.
13. Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z. 2013. Establishment and characterization of a tamoxifen-mediated reversible immortalized mouse dental papilla cell line. In Vitro Cell Dev Biol Anim 49:114-121.
14. Miraoui H, Oudina K, Petite H, Tanimoto Y, Moriyama K, Marie PJ. 2009. Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling. J Biol Chem 284:4897-4904.
15. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29.
16. O'Keefe RJ, Mao J. 2011. Bone tissue engineering and regeneration: From discovery to the clinic-An overview. Tissue Eng B Rev 17:389-392.
17. Paik S, Jung HS, Lee S, Yoon DS, Park MS, Lee JW. 2012. MiR-449a regulates the chondrogenesis of human mesenchymal stem cells through direct targeting of lymphoid enhancer-binding factor-1. Stem Cells Dev 21:3298-3308.
18. Phinney DG, Prockop DJ. 2007. Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair-Current views. Stem Cells 25:2896-2902.
19. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M, Bianco P. 2007. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131:324-336.
20. Salmon P, Oberholzer J, Occhiodoro T, Morel P, Lou J, Trono D. 2000. Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther 2:404-414.
21. Sugawara M, Kato N, Tsuchiya T, Motoyama T. 2011. RUNX2 expression in developing human bones and various bone tumors. Pathol Int 61:565-571.
22. Sun Q, Liu H, Lin H, Yuan G, Zhang L, Chen Z. 2013. MicroRNA-338-3p promotes differentiation of mDPC6T into odontoblast-like cells by targeting Runx2. Mol Cell Biochem.
23. Teplyuk NM, Haupt LM, Ling L, Dombrowski C, Mun FK, Nathan SS, Lian JB, Stein JL, Stein GS, Cool SM, van Wijnen AJ. 2009. The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts. J Cell Biochem 107:144-154.
24. Tu Q, Valverde P, Chen J. 2006. Osterix enhances proliferation and osteogenic potential of bone marrow stromal cells. Biochem Biophys Res Commun 341:1257-1265.
25. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ. 2002. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55:693-698.
26. Wang T, Xu Z. 2010. MiR-27 promotes osteoblast differentiation by modulating Wnt signaling. Biochem Biophys Res Commun 402:186-189.
27. Wang Q, Cai J, Cai XH, Chen L. 2013. MiR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/beta-catenin pathway. PLoS ONE 8:e72266.
28. Zeng Y, Qu X, Li H, Huang S, Wang S, Xu Q, Lin R, Han Q, Li J, Zhao RC. 2012. MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2. FEBS Lett 586:2375-2381.
29. Zhang J, Tu Q, Grosschedl R, Kim MS, Griffin T, Drissi H, Yang P, Chen J. 2011. Roles of SATB2 in osteogenic differentiation and bone regeneration. Tissue Eng A 17:1767-1776.
30. Zhu H, Guo ZK, Jiang XX, Li H, Wang XY, Yao HY, Zhang Y, Mao N. 2010. A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc 5:550-560.