Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone

Bone

Volumn 34, Issue 3, 2004, Pages 393-401

  Huang, L ^a   Teng, X Y ^a   Cheng, Y Y ^a   Lee, K M ^a   Kumta, S M ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

BMP 2; Cbfa 1; Giant cell tumour of bone; Osteoblast; Osterix

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; GLYCEROL 2 PHOSPHATE; MESSENGER RNA; OSTEOCALCIN; OSTEONECTIN; PROTEIN; PROTEIN OSTERIX; SIALOPROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ARTICLE; BONE TUMOR; CELL CULTURE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; GIANT CELL TUMOR; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; OSTEOBLAST; PROTEIN EXPRESSION; SKIN FIBROBLAST; TRANSCRIPTION REGULATION;

ANALYSIS OF VARIANCE; BONE MORPHOGENETIC PROTEINS; BONE NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GIANT CELL TUMOR OF BONE; HUMANS; NEOPLASM PROTEINS; OSTEOBLASTS; STROMAL CELLS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 1542286116     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2003.10.013     Document Type: Article

References (29)

1. Goldring S.R., Roelke M.S., Petrison K.K., Bhan A.K. Human giant cell tumors of bone identification and characterization of cell types. J. Clin. Invest. 79:1987;483-491.
2. Athanasou N.A., Bliss E., Gatter K.C., Heryet A., Woods C.G., McGee J.O. An immunohistological study of giant-cell tumour of bone: evidence for an osteoclast origin of the giant cells. J. Pathol. 147:1985;153-158.
3. Zheng M.H., Robbins P., Xu J., Huang L., Wood D.J., Papadimitriou J.M. The histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts. Histol. Histopathol. 16:2001;297-307.
4. Robinson D., Einhorn T.A. Giant cell tumor of bone: a unique paradigm of stromal-hematopoietic cellular interactions. J. Cell. Biochem. 55:1994;300-303.
5. Huang L., Xu J., Wood D.J., Zheng M.H. Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. Am. J. Pathol. 156:2000;761-767.
6. Emura I., Inoue Y., Ohnishi Y., Morita T., Saito H., Tajima T. Histochemical, immunohistochemical and ultrastructural investigations of giant cell tumors of bone. Acta Pathol. Jpn. 36:1986;691-702.
7. Joyner C.J., Quinn J.M., Triffitt J.T., Owen M.E., Athanasou N.A. Phenotypic characterisation of mononuclear and multinucleated cells of giant cell tumour of bone. Bone Miner. 16:1992;37-48.
8. Watanabe K., Tajino T., Kusakabe T., Saitoh A., Suzuki T. Giant cell tumor of bone: frequent actin immunoreactivity in stromal tumor cells. Pathol. Int. 47:1997;680-684.
9. James I.E., Dodds R.A., Olivera D.L., Nuttall M.E., Gowen M. Human osteoclastoma-derived stromal cells: correlation of the ability to form mineralized nodules in vitro with formation of bone in vivo. J. Bone Miner. Res. 11:1996;1453-1460.
10. Aubin J.E., Liu F. The osteoblast lineage. Bilezikian J.P., Raisz L.G., Rodan G.A. Principles of bone biology. 1996;51-67 Academic Press, San Diego, CA.
11. Caplan A.I. Mesenchymal stem cells. J. Orthop. Res. 9:1991;641-650.
12. Beresford J.N. Osteogenic stem cells and the stromal system of bone and marrow. Clin. Orthop. 240:1989;270-280.
13. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D.et al. Multilineage potential of adult human mesenchymal stem cells. Science. 284:1999;143-147.
14. Katagiri T., Yamaguchi A., Ikeda T., Yoshiki S., Wozney J.M., Rosen V.et al. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem. Biophys. Res. Commun. 172:1990;295-299.
15. Yamaguchi A., Katagiri T., Ikeda T., Wozney J.M., Rosen V., Wang E.A.et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J. Cell Biol. 113:1991;681-687.
16. Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T.et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127(6 Pt 1):1994;1755-1766.
17. Gitelman S.E., Kirk M., Ye J.Q., Filvaroff E.H., Kahn A.J., Derynck R. Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth Differ. 6:1995;827-836.
18. Ducy P., Zhang R., Geoffroy V., Ridall A.L., Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 89:1997;747-754.
19. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K.et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 89:1997;755-764.
20. Harada H., Tagashira S., Fujiwara M., Ogawa S., Katsumata T., Yamaguchi A.et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J. Biol. Chem. 274:1999;6972-6978.
21. Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R.et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 108:2002;17-29.
22. P. Ducy, And then they were two... progressing along the osteoblast differentiation pathway. IBMS BoneKEy (online). Available at: http://www.bonekey-ibms.org/cgi/content/full/ibmske ; 2002029v1. Accessed Feb. 26, 2002.
23. Zhang X., Schwarz E.M., Young D.A., Puzas J.E., Rosier R.N., O'Keefe R.J. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J. Clin. Invest. 109:2002;1405-1415.
24. Fornasier V.L., Protzner K., Zhang I., Mason L. The prognostic significance of histomorphometry and immunohistochemistry in giant cell tumors of bone. Hum. Pathol. 27:1996;754-760.
25. Masui F., Ushigome S., Fujii K. Giant cell tumor of bone: an immunohistochemical comparative study. Pathol. Int. 48:1998;355-361.
26. Abe E., Yamamoto M., Taguchi Y., Lecka-Czernik B., O'Brien C.A., Economides A.N.et al. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J. Bone Miner. Res. 15:2000;663-673.
27. Koide M., Murase Y., Yamato K., Noguchi T., Okahashi N., Nishihara T. Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2. Biochem. Biophys. Res. Commun. 259:1999;97-102.
28. Itoh K., Udagawa N., Katagiri T., Iemura S., Ueno N., Yasuda H.et al. Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand. Endocrinology. 142:2001;3656-3662.
29. Atkins G.J., Haynes D.R., Graves S.E., Evdokiou A., Hay S., Bouralexis S.et al. Expression of osteoclast differentiation signals by stromal elements of giant cell tumors. J. Bone Miner. Res. 15:2000;640-649.