Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

Archives of Toxicology

Volumn 88, Issue 7, 2014, Pages 1427-1437

  Sjogren, Anna Karin M ^a   Liljevald, Maria ^a   Glinghammar, Björn ^a   Sagemark, Johanna ^a   Li, Xue Qing ^a   Jonebring, Anna ^a   Cotgreave, Ian ^b   Brolén, Gabriella ^a   Andersson, Tommy B ^a,b  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Acetaminophen; Apoptosis; Drug induced liver injury; HepaRG; Hepatotoxicity; iPS cells

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; CASPASE 3; CASPASE 7; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOKERATIN 18; DICLOFENAC; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; KRUPPEL LIKE FACTOR 4; MIDAZOLAM; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC ANION TRANSPORTER B; PARACETAMOL; PHENACETIN; PREGNANE X RECEPTOR; STAGE SPECIFIC EMBRYO ANTIGEN 4; STAUROSPORINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR SOX2;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; METABOLIC ACTIVATION; NEWBORN; PLURIPOTENT STEM CELL; PREPUCE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; TOXICITY TESTING; TREATMENT RESPONSE; CELL CULTURE; CELL LINE; COMPARATIVE STUDY; CRYOPRESERVATION; CYTOLOGY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; FIBROBLAST; MALE; METABOLISM; PROCEDURES; TOXICITY;

IPS;

ACETAMINOPHEN; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CRYOPRESERVATION; DRUG-INDUCED LIVER INJURY; FIBROBLASTS; FORESKIN; HEPATOCYTES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; PRINCIPAL COMPONENT ANALYSIS; STAUROSPORINE; TOXICITY TESTS;

EID: 84903437158     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1265-z     Document Type: Article

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