Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012

Malaria Journal

Volumn 13, Issue 1, 2014, Pages

  Juma, Dennis W ^a   Omondi, Angela A ^a   Ingasia, Luiser ^a   Opot, Benjamin ^a   Cheruiyot, Agnes ^a   Yeda, Redemptah ^a   Okudo, Charles ^a   Cheruiyot, Jelagat ^a   Muiruri, Peninnah ^a   Ngalah, Bidii ^a   Chebon, Lorna J ^a   Eyase, Fredrick ^a   Johnson, Jacob ^a   Bulimo, Wallace D ^a   Akala, Hoseah M ^a   Andagalu, Ben ^a   Kamau, Edwin ^a  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

Malaria; Plasmodium falciparum dihydrofolate reductase; Plasmodium falciparum dihydropteroate synthase

Indexed keywords

PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CODON; FIELD STUDY; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC MARKER; GENOTYPE; HUMAN; INFANT; KENYA; MAJOR CLINICAL STUDY; MALARIA CONTROL; MALARIA FALCIPARUM; MICROBIAL GENE; PARASITE PREVALENCE; PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE GENE; PLASMODIUM FALCIPARUM DIHYDROPTEROATE SYNTHASE GENE; POPULATION GENETIC STRUCTURE; PUBLIC HOSPITAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREND STUDY; ADOLESCENT; ADULT; AGED; CHILD; DNA SEQUENCE; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETICS; MALE; MIDDLE AGED; PLASMODIUM FALCIPARUM; PREGNANCY; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE; FEMALE; HUMANS; INFANT; KENYA; MALE; MIDDLE AGED; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PREGNANCY; SEQUENCE ANALYSIS, DNA; TETRAHYDROFOLATE DEHYDROGENASE; YOUNG ADULT;

EID: 84903420058     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-13-250     Document Type: Article

References (34)

1. Treatment failure of pyrimethamine-sulphadoxine and induction of Plasmodium falciparum gametocytaemia in children in western Kenya. Bousema JT, Gouagna LC, Meutstege AM, Okech BE, Akim NI, Githure JI, Beier JC, Sauerwein RW, Trop Med Int Health 2003 8 427 430 10.1046/j.1365-3156.2003.01047.x 12753638 (Pubitemid 36733594)
2. The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya. Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH, Watkins WM, Am J Trop Med Hyg 2000 62 396 401 11037785
3. The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya. Amin AA, Zurovac D, Kangwana BB, Greenfield J, Otieno DN, Akhwale WS, Snow RW, Malar J 2007 6 72 10.1186/1475-2875-6-72 17535417 (Pubitemid 46919082)
4. Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. Peters PJ, Thigpen MC, Parise ME, Newman RD, Drug Saf 2007 30 481 501 10.2165/00002018-200730060-00003 17536875 (Pubitemid 46873074)
5. WHO, Report of the Technical Consultation on Intermittent Preventive Treatment in Infants (IPTi), Technical Expert Group on Preventive Chemotherapy Geneva: World Health Organization 2009
6. Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations. Sridaran S, McClintock SK, Syphard LM, Herman KM, Barnwell JW, Udhayakumar V, Malar J 2010 9 247 10.1186/1475-2875-9-247 20799995
7. Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. McCollum AM, Poe AC, Hamel M, Huber C, Zhou Z, Shi YP, Ouma P, Vulule J, Bloland P, Slutsker L, Barnwell JW, Udhayakumar V, Escalante AA, J Infect Dis 2006 194 189 197 10.1086/504687 16779725 (Pubitemid 44087190)
8. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Peterson DS, Wallikier D, Wellems TE, Proc Natl Acad Sci U S A 1988 85 9114 9118 10.1073/pnas.85.23.9114 2904149 (Pubitemid 19001850)
9. Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Triglia T, Menting JG, Wilson C, Cowman AF, Proc Natl Acad Sci U S A 1997 94 13944 13949 10.1073/pnas.94.25. 13944 9391132 (Pubitemid 28009689)
10. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM, Antimicrob Agents Chemother 1998 42 164 169 9449279 (Pubitemid 28053345)
11. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. Kublin JG, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino LM, Mukadam RA, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA, Chimpeni P, Taylor TE, Plowe CV, J Infect Dis 2002 185 380 388 10.1086/338566 11807721 (Pubitemid 34107252)
12. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Foote SJ, Galatis D, Cowman AF, Proc Natl Acad Sci U S A 1990 87 3014 3017 10.1073/pnas.87.8.3014 2183221
13. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. Plowe CV, Cortese JF, Djimde A, Nwanyanwu OC, Watkins WM, Winstanley PA, Estrada-Franco JG, Mollinedo RE, Avila JC, Cespedes JL, Carter D, Doumbo OK, J Infect Dis 1997 176 1590 1596 10.1086/514159 9395372 (Pubitemid 27518161)
14. Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya. Oesterholt MJ, Alifrangis M, Sutherland CJ, Omar SA, Sawa P, Howitt C, Gouagna LC, Sauerwein RW, Bousema T, PLoS One 2009 4 4364 10.1371/journal.pone.0004364 19194499
15. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. Triglia T, Wang P, Sims PF, Hyde JE, Cowman AF, EMBO J 1998 17 3807 3815 10.1093/emboj/17.14.3807 9669998 (Pubitemid 28333967)
16. Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole. Khalil I, Ronn AM, Alifrangis M, Gabar HA, Satti GM, Bygbjerg IC, Am J Trop Med Hyg 2003 68 586 589 12812351 (Pubitemid 38240499)
17. Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya. Mbaisi A, Liyala P, Eyase F, Achilla R, Akala H, Wangui J, Mwangi J, Osuna F, Alam U, Smoak BL, Davis JM, Kyle DE, Coldren RL, Mason C, Waters NC, Antimicrob Agents Chemother 2004 48 3598 3601 10.1128/AAC.48.9.3598-3601.2004 15328137 (Pubitemid 39129371)
18. Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya. Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC, Malar J 2010 9 338 10.1186/1475-2875-9-338 21106088
19. Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya. Iriemenam NC, Shah M, Gatei W, van Eijk AM, Ayisi J, Kariuki S, Vanden Eng J, Owino SO, Lal AA, Omosun YO, Otieno K, Desai M, ter Kuile FO, Nahlen B, Moore J, Hamel MJ, Ouma P, Slutsker L, Shi YP, Malar J 2012 11 134 10.1186/1475-2875-11-134 22540158
20. Reemergence of epidemic malaria in the highlands of western Kenya. Malakooti MA, Biomndo K, Shanks GD, Emerg Infect Dis 1998 4 671 676 10.3201/eid0404.980422 9866748 (Pubitemid 28553696)
21. Changing malaria intervention coverage, transmission and hospitalization in Kenya. Emelda AO, Victor AA, Abdisalan MN, Robert WS, Malar J 2010 9 285 10.1186/1475-2875-9-285 20946689
22. Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana. Alam MT, de Souza DK, Vinayak S, Griffing SM, Poe AC, Duah NO, Ghansah A, Asamoa K, Slutsker L, Wilson MD, Barnwell JW, Udhayakumar V, Koram KA, J Infect Dis 2011 203 220 227 10.1093/infdis/jiq038 21288822
23. Origin and evolution of sulfadoxine resistant Plasmodium falciparum. Vinayak S, Alam MT, Mixson-Hayden T, McCollum AM, Sem R, Shah NK, Lim P, Muth S, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F, Meshnick SR, Udhayakumar V, PLoS Pathog 2010 6 1000830 10.1371/journal.ppat. 1000830 20360965
24. Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru. Zhou Z, Griffing SM, de Oliveira AM, McCollum AM, Quezada WM, Arrospide N, Escalante AA, Udhayakumar V, Antimicrob Agents Chemother 2008 52 739 741 10.1128/AAC.00975-07 18025120 (Pubitemid 351170855)
25. Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand. Alam MT, Vinayak S, Congpuong K, Wongsrichanalai C, Satimai W, Slutsker L, Escalante AA, Barnwell JW, Udhayakumar V, Antimicrob Agents Chemother 2011 55 155 164 10.1128/AAC.00691-10 20956597
26. Drugs for preventing malaria in pregnant women. Garner P, Gulmezoglu AM, Garner P, Gulmezoglu AM, Cochrane Database Syst 2006 http://onlinelibrary.wiley. com/doi/10.1002/14651858.CD000169.pub2/full
27. Effect of trimethroprim-sulfamethazole on the risk of malaria in HIV infected Ugandan children living in an area of widespread antifolate resistance. Gasaira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G, Gasaira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G, Malar J 2010 9 177 10.1186/1475-2875-9-177 20573194
28. The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum. Le Bras J, Durand R, Fundam Clin Pharmacol 2003 17 147 153 10.1046/j.1472-8206.2003.00164.x 12667224 (Pubitemid 36513205)
29. High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. Gesase S, Gosling RD, Hashim R, Ord R, Naidoo I, Madebe R, Mosha JF, Joho A, Mandia V, Mrema H, Mapunda E, Savael Z, Lemnge M, Mosha FW, Greenwood B, Roper C, Chandramohan D, PLoS One 2009 4 4569 10.1371/journal.pone.0004569 19238219
30. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Wang P, Lee CS, Bayoumi R, Djimde A, Doumbo O, Swedberg G, Dao LD, Mshinda H, Tanner M, Watkins WM, Sims PF, Hyde JE, Mol Biochem Parasitol 1997 89 161 177 10.1016/S0166-6851(97)00114-X 9364963 (Pubitemid 27435090)
31. The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics. Ishraga A-E, Michael A, Insaf K, Ib B, Emad M, Mustafa E, Hayder G, Malar J 2007 6 108 10.1186/1475-2875-6-108 17686173 (Pubitemid 350092571)
32. Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene. Alifrangis M, Lusingu JP, Mmbando B, Dalgaard MB, Vestergaard LS, Ishengoma D, Khalil IF, Theander TG, Lemnge MM, Bygbjerg IC, Am J Trop Med Hyg 2009 80 523 527 19346369
33. Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya. McCollum AM, Schneider KA, Griffing SM, Zhou Z, Kariuki S, Ter-Kuile F, Shi YP, Slutsker L, Lal AA, Udhayakumar V, Escalante AA, Malar J 2012 11 77 10.1186/1475-2875-11-77 22439637
34. Shifts in malaria vector species composition and transmission dynamics along the Kenyan coast over the past 20 years. Mwangangi JM, Mbogo CM, Orindi BO, Muturi EJ, Midega JT, Nzovu J, Gatakaa H, Githure J, Borgemeister C, Keating J, Beier JC, Malar J 2013 12 13 10.1186/1475-2875-12-13 23297732