Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya

Malaria Journal

Volumn 11, Issue , 2012, Pages

  McCollum, Andrea M ^a,b,c   Schneider, Kristan A ^d   Griffing, Sean M ^a,b   Zhou, Zhiyong ^b,c   Kariuki, Simon ^e   Ter Kuile, Feiko ^f   Shi, Ya Ping ^b   Slutsker, Laurence ^b   Lal, Altaf A ^b   Udhayakumar, Venkatachalam ^b   Escalante, Ananias A ^g,h  

^a EMORY UNIVERSITY   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c ATLANTA RESEARCH AND EDUCATION FOUNDATION   (United States)

^d UNIVERSITY OF VIENNA   (Austria)

^e KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^f LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^g ARIZONA STATE UNIVERSITY   (United States)

^h ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Dihydrofolate Reductase; Dihydropterote synthase; Drug resistance; Malaria; Natural selection; Plasmodium; Selective sweep; Sulphadoxine pyrimethamine

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROTE SYNTHASE; PYRIMETHAMINE PLUS SULFADOXINE; SYNTHETASE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; DIHYDROPTEROATE SYNTHASE; MICROSATELLITE DNA; PROTOZOAL PROTEIN; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ALLELE; ARTICLE; BLOOD SAMPLING; CHILD; CHROMOSOME; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; INFANT; KENYA; MULTIDRUG RESISTANCE; MUTANT; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PYROSEQUENCING; DRUG COMBINATION; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; GENETIC RECOMBINATION; GENETIC SELECTION; GENETICS; LONGITUDINAL STUDY; MALARIA FALCIPARUM; MUTATION; PARASITOLOGY; PHYLOGEOGRAPHY;

ALLELES; ANTIMALARIALS; DIHYDROPTEROATE SYNTHASE; DRUG COMBINATIONS; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; HUMANS; KENYA; LONGITUDINAL STUDIES; MALARIA, FALCIPARUM; MICROSATELLITE REPEATS; MUTATION; PHYLOGEOGRAPHY; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; PYRIMETHAMINE; RECOMBINATION, GENETIC; SELECTION, GENETIC; SULFADOXINE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84862819556     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-77     Document Type: Article

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