Mechanistic, Mathematical Model to Predict the Dynamics of Tissue Genesis in Bone Defects via Mechanical Feedback and Mediation of Biochemical Factors

PLoS Computational Biology

Volumn 10, Issue 6, 2014, Pages

  Moore, Shannon R ^a   Saidel, Gerald M ^a   Knothe, Ulf ^b   Knothe Tate, Melissa L ^a,c,d  

^a Case Western Reserve University   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Case Western Reserve University   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; FINITE ELEMENT METHOD; MECHANISMS; STRAIN; TISSUE REGENERATION;

BIOLOGICAL INTERACTIONS; BONE DEFECT; FRACTURE HEALING; IN CONTEXTS; MECHANICAL; MECHANISTICS; PROGENITOR CELL; QUANTITATIVE EVALUATION; SKELETAL DEVELOPMENT; SKELETAL FRACTURES;

BONE;

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE MARROW CELL; BONE MINERALIZATION; BONE REGENERATION; CARTILAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPUTER MODEL; COMPUTER PREDICTION; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; EXPERIMENTAL SHEEP; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; FINITE ELEMENT ANALYSIS; FRACTURE HEALING; HISTOLOGY; INTRAMEDULLARY NAILING; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; OSTEOBLAST; PERIOSTEUM; PREDICTIVE VALUE; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SPATIOTEMPORAL ANALYSIS; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; BIOMECHANICS; BONE NAIL; CHONDROGENESIS; COMPUTER SIMULATION; CYTOLOGY; HUMAN; MESENCHYMAL STROMA CELL; PHYSIOLOGY; SHEEP;

ANIMALS; BIOMECHANICAL PHENOMENA; BONE MORPHOGENETIC PROTEINS; BONE NAILS; BONE REGENERATION; CHONDROGENESIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; FEEDBACK, PHYSIOLOGICAL; FINITE ELEMENT ANALYSIS; FRACTURE HEALING; HUMANS; MESENCHYMAL STROMAL CELLS; MODELS, ANIMAL; MODELS, BIOLOGICAL; OSTEOGENESIS; PERIOSTEUM; SHEEP;

EID: 84903398944     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003604     Document Type: Article

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