Use of the rat forelimb compression model to create discrete levels of bone damage in vivo

Journal of Biomechanics

Volumn 40, Issue 2, 2007, Pages 317-324

  Uthgenannt, Brian A ^a   Silva, Matthew J ^a  

^a BARNES JEWISH HOSPITAL   (United States)

Author keywords

Bone damage; Bone fatigue; In vivo forelimb loading; Rat ulna

Indexed keywords

BIODIVERSITY; COMPUTERIZED TOMOGRAPHY; CYCLIC LOADS; FRACTURE; PHYSIOLOGICAL MODELS;

BONE DAMAGE; BONE FATIGUE; IN VIVO FORELIMB LOADING; RAT ULNA;

BIOMECHANICS;

ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE INJURY; BONE STRENGTH; COMPRESSION; CONTROLLED STUDY; DOSE RESPONSE; FORCE; FORELIMB; FRACTURE DISLOCATION; FRAGILITY FRACTURE; IN VIVO STUDY; INJURY SCALE; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS FRACTURE; STRESS STRAIN RELATIONSHIP; ULNA; WEIGHT BEARING;

ANIMALS; BONES OF UPPER EXTREMITY; COMPRESSIVE STRENGTH; MALE; MODELS, ANIMAL; RATS; RATS, INBRED F344; ULNA;

EID: 33845777529     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2006.01.005     Document Type: Article

References (22)

1. Bentolila V., Boyce T.M., Fyhrie D.P., Drumb R., Skerry T.M., and Schaffler M.B. Intracortical remodeling in adult rat long bones after fatigue loading. Bone 23 (1998) 275-281
2. Burr D.B., Forwood M.R., Fyhrie D.B., Martin R.B., Schaffler M.B., and Turner C.H. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. Journal of Bone Mineral Research 12 (1997) 6-15
3. Caler W.E., and Carter D.R. Bone creep-fatigue damage accumulation. Journal of Biomechanics 22 (1989) 625-635
4. Carter D.R., and Caler W.E. A cumulative damage model for bone fracture. Journal of Orthopaedic Research 3 (1985) 84-90
5. Carter D.R., and Hayes W.C. Fatigue life of compact bone-I: effects of stress amplitude, temperature and density. Journal of Biomechanics 9 (1976) 27-34
6. Colopy S.A., Benz-Dean J., Barrett J.G., Sample S.J., Lu Y., Danova N.A., Kalscheur V.L., Vanderby Jr. R., Markel M.D., and Muir P. Response of the osteocyte syncytium adjacent to and distant from linear microcracks during adaptation to cyclic fatigue loading. Bone 35 (2004) 881-891
7. Cotton J.R., Winwood K., Zioupos P., and Taylor M. Damage rate is a predictor of fatigue life and creep strain rate in tensile fatigue of human cortical bone samples. Journal of Biomechanical Engineering 127 (2005) 213-219
8. Danova N.A., Colopy S.A., Radtke C.L., Kalscheur V.L., Markel M.D., Vanderby R., McCabe R.P., Escarcega A.J., and Muir P. Degradation of bone structural properties by accumulation and coalescence of microcracks. Bone 33 (2003) 197-205
9. Forwood M.R., Owan I., Takano Y., and Turner C.H. Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo. American Journal of Physiology 270 (1996) E419-E423
10. Fritton S.P., and Rubin C.T. In vivo measurement of bone deformations using strain gauges. In: Cowin S.C. (Ed). Bone Mechanics Handbook (2001), CRC, Boca Raton pp. 8-1-8-41
11. Hsieh Y.F., and Silva M.J. In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density. Journal of Orthopaedic Research 20 (2002) 764-771
12. Hsieh Y.-F., Robling A.G., Ambrosius W.T., Burr D.B., and Turner C.H. Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location. Journal of Bone Mineral Research 16 (2001) 2291-2297
13. Kotha S.P., Hsieh Y.-F., Strigel R.M., Muller R., and Silva M.J. Experimental and finite element analysis of the rat ulnar loading model-correlations between strain and bone formation following fatigue loading. Journal of Biomechanics 37 (2003) 541-548
14. Mori S., and Burr D.B. Increased intracortical remodeling following fatigue damage. Bone 14 (1993) 103-109
15. Nalla R.K., Kinney J.H., and Ritchie R.O. Mechanistic fracture criteria for the failure of human cortical bone. Nature Materials 2 (2003) 164-168
16. Pattin C.A., Caler W.E., and Carter D.R. Cyclic mechanical property degradation during fatigue loading of cortical bone. Journal of Biomechanics 29 (1996) 69-79
17. Robling A.G., Duijvelaar K.M., Geevers J.V., Ohashi N., and Turner C.H. Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force. Bone 29 (2001) 105-113
18. Schaffler M.B. Bone fatigue and remodeling in the development of stress fractures. In: Burr D.B., and Milgrom C. (Eds). Musculoskeletal Fatigue and Stress Fractures (2001), CRC Press, Boca Raton 161-182
19. Shaffer R.A. Incidence and prevalence of stress fractures in military and athletic populations. In: Burr D.B., and Milgrom C. (Eds). Musculoskeletal Fatigue and Stress Fractures (2001), CRC Press, Boca Raton 1-14
20. Tami A.E., Nasser P., Schaffler M.B., and Knothe Tate M.L. Noninvasive fatigue fracture model of the rat ulna. Journal of Orthopaedic Research 21 (2003) 1018-1024
21. Torrance A.G., Mosley J.R., Suswillo R.F.L., and Lanyon L.E. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periosteal pressure. Calcified Tissue International 54 (1994) 241-247
22. Verborgt O., Gibson G.J., and Schaffler M.B. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. Journal of Bone Mineral Research 15 (2000) 60-67