A mathematical framework to study the effects of growth factor influences on fracture healing

Journal of Theoretical Biology

Volumn 212, Issue 2, 2001, Pages 191-209

  Bailón Plaza, Alicia ^a   Van Der Meulen, Marjolein C H ^a  

^a Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYTOKINE; GROWTH FACTOR; INTERLEUKIN 1; INTERLEUKIN 6; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA;

BONE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE REGENERATION; CALLUS; CARTILAGE CELL; CELL DIFFERENTIATION; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; FRACTURE; FRACTURE HEALING; MESENCHYME CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL;

EID: 0035929385     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2372     Document Type: Article

References (55)

1. A fuzzy logic model of fracture healing
2. The behavior of fibroblasts from the developing avian cornea. Morphology and movement in situ and in vitro
3. Growth factor regulation of fracture repair
4. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia
5. Role of mechanical loading in the progressive ossification of a fracture callus
6. Collagen and bone strength
7. Expression of bone morphogenetic proteins in fracture healing
8. Transforming growth factor beta in fracture repair
9. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing
10. The mesengenic process
11. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing
12. Pharmacokinetics of TGF beta with emphasis on effects in liver and gut
13. The effect of exogenous transforming growth factor-beta 2 on healing fractures in the rabbit
14. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and tansforming growth factor beta 2 affinity purification
15. A mathematical model for outgrowth and spatial patterning of the vertebrate limb bud
16. Cellular response to transforming growth factor-β1 and basic fibroblast growth factor depends on release kinetics and extracellular matrix interactions
17. Perivascular and intravenous administration of basic fibroblast growth factor: Vascular and solid organ deposition
18. The cell and molecular biology of fracture healing
19. Cellular modeling of mechanical interactions with the skeleton
20. Towards a molecular understanding of skeletal development
21. Cell proliferation of human fibroblasts and osteoblasts in osteogenesis imperfecta: Influence of age
22. Does adult fracture repair recapitulate embryonic skeletal formation?
23. Diffusion of paramagnetically labeled proteins in cartilage: Enhancement of the 1-D NMR imaging technique
24. Cell migration strategies in 3-d extracellular matrix: Differences in morphology, cell matrix interactions, and integrin function
25. The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture - An FEM study
26. Analysis of cell movement
27. Regulation of chondrocyte differentiation and maturation
28. Regulation of extracellular matrix genes during fracture healing in mice
29. Retarded chondrogenesis in transgenic mice with a type II collagen defect results in fracture healing abnormalities
30. Current concepts of fracture healing
31. Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur
32. Role of transforming growth factor-β in fracture repair
33. BMP-5 and the molecular, skeletal, and soft-tissue alterations in short ear mice
34. Osteogenesis imperfecta
35. Cellular physiology
36. Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: Implication for function
37. Growth factors for bone growth and repair
38. Bones, feathers, teeth and coat markings: A unified model
39. Subtle differences in the mitogenic effects of recombinant human bone morphogenetic proteins -2 to -7 on DNA synthesis on primary bone-forming cells and identification of BMP-2/4 receptor
40. Regulation of osteoblast levels during bone healing
41. A mechanochemical model for adult dermal wound contraction and the permanence of the contracted tissue displacement profile
42. A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis
43. The concept of interfragmentary strain
44. Initiation of fracture repair by bone morphogentic proteins
45. Transforming growth factor-beta 1 modulates the expression of vascular endothelial growth factor by osteoblasts
46. Bone morphogenetic proteins: From basic studies to clinical approaches
47. Gene expression during bone repair
48. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis
49. Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva
50. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair
51. Regulation of proliferation of bovine aortic endothelial cells, smooth muscle cells, and adventitial fibroblasts in collagen lattices