Dose-independent pharmacokinetics of metformin in rats: Hepatic and gastrointestinal first-pass effects

Journal of Pharmaceutical Sciences

Volumn 95, Issue 11, 2006, Pages 2543-2552

  Choi, Young H ^a   Kim, Sang G ^a   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

Author keywords

Gastrointestinal and hepatic first pass effects; Metformin; Pharmacokinetics; Rats

Indexed keywords

HUMAN SERUM ALBUMIN; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG STABILITY; EQUILIBRIUM DIALYSIS; FIRST PASS EFFECT; GASTROINTESTINAL ABSORPTION; LIVER CIRCULATION; MALE; NONHUMAN; PORTAL VEIN; RAT; TISSUE HOMOGENATE;

EID: 33750053217     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20744     Document Type: Article

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