Parent-of-Origin Effects in ADHD: Distinct Influences of Paternal and Maternal ADHD on Neuropsychological Functioning in Offspring

Journal of Attention Disorders

Volumn 18, Issue 6, 2014, Pages 521-531

  Thissen, Andrieke J A M ^a   Rommelse, Nanda N J ^a   Altink, Marieke E ^a   Oosterlaan, Jaap ^b   Buitelaar, Jan K ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c RADBOUD UNIVERSITY   (Netherlands)

Author keywords

ADHD; endophenotype; intergenerational transmission; neuropsychological functioning; parent of origin

Indexed keywords

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; EXECUTIVE FUNCTION; FAMILY; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; INHIBITION (PSYCHOLOGY); MALE; PARENT; PHYSIOLOGY; PSYCHOLOGY; SELF REPORT;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; EXECUTIVE FUNCTION; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; PARENTS; SELF REPORT;

EID: 84903393403     PISSN: 10870547     EISSN: 15571246     Source Type: Journal    
DOI: 10.1177/1087054712443159     Document Type: Article

References (77)

1. Alberts-Corush J.,Firestone P.,Goodman J. T.Attention and impulsivity characteristics of the biological and adoptive parents of hyperactive and normal control children.American Journal of Orthopsychiatry. 1986;56:413-423.
2. Diagnostic and statistical manual of mental disorders. 1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.Washington, DC: Author; 1994:.
3. Diagnostic and statistical manual of mental disorders. 2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.Washington, DC: Author; 2000:.
4. Anney R. J. L.,Hawi Z.,Sheehan K.,Mulligan A.,Pinto C.,Brookes K. J.,. Gill M.Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the International Multicenter ADHD Genetics (IMAGE) Program.American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B. 2008;:1495-1500.
5. Becker J. B.Gender differences in dopaminergic function in striatum and nucleus accumbens.Pharmacology, Biochemistry and Behavior. 1999;64:803-812.
6. Benjamini Y.,Hochberg Y.Controlling the false discovery rate-A practical and powerful approach to multiple testing.Journal of the Royal Statistical Society Series B-Methodological. 1995;57:289-300.
7. Berquin P. C.,Giedd J. N.,Jacobsen L. K.,Hamburger S. D.,Krain A. L.,Rapoport J. L.,Castellanos F. X.Cerebellum in attention-deficit hyperactivity disorder-A morphometric MRI study.Neurology. 1998;50:1087-1093.
8. Biederman J.,Mick E.,Faraone S. V.Age-dependant decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type.American Journal of Psychiatry. 2000;157:816-818.
9. Brookes K. J.,Mill J.,Guindalini C.,Curran S.,Xu X.,Knight J.,. Asherson P.A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.Archives of General Psychiatry. 2006;63:74-81.
10. Castellanos F. X.,Tannock R.Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes.Nature Reviews Neuroscience. 2002;3:617-628.
11. Cattanach B. M.,Kirk M.Differential activity of maternally and paternally derived chromosome regions in mice.Nature. 1985;315:496-498.
12. Coghill D.,Nigg J.,Rothenberger A.,Sonuga-Barke E.,Tannock R.Whither causal models in the neuroscience of ADHD?.Developmental Science. 2005;8:105-114.
13. Conners C. K.Rating scales in attention-deficit/hyperactivity disorder: Use in assessment and treatment monitoring.Journal of Clinical Psychiatry. 1998;59:24-30.
14. Conners C. K.,Erhardt D.,Epstein J. N.,Parker J. D. A.,Sitarenios G.,Sparrow E.Self-ratings of ADHD symptoms in adults I: Factor structure and normative data.Journal of Attention Disorders. 1999;3:151-151.
15. Cook E. H.,Lindgren V.,Leventhal B. L.,Courchesne R.,Lincoln A.,Shulman C.,. Courchesne E.Autism or atypical autism in maternally but not paternally derived proximal 15q duplication.American Journal of Human Genetics. 1997;60:928-934.
16. Cornish K. M.,Manly T.,Savage R.,Swanson J.,Morisano D.,Butler N.,. Hollis C. P.Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample.Molecular Psychiatry. 2005;10:686-698.
17. Crosbie J.,Schachar R.Deficient inhibition as a marker for familial ADHD.American Journal of Psychiatry. 2001;158:1884-1890.
18. Cummins T. D. R.,Hawi Z.,Hocking J.,Strudwick M.,Hester R.,Garavan H.,. Bellgrove M. A.Dopamine transporter genotype predicts behavioural and neural measures of response inhibition.Molecular Psychiatry. 2011;:.
19. Curko Kera E. A.,Marks D. J.,Berwid O. G.,Santra A.,Halperin J. M.Self-Report and objective measures of ADHD-related behaviors in parents of preschool children at risk for ADHD.CNS, Spectrums. 2004;9:639-647.
20. Duncan J.,Emslie H.,Williams P.,Johnson R.,Freer C.Intelligence and the frontal lobe: The organization of goal-directed behavior.Cognitive Psychology. 1996;30:257-303.
21. Durston S.,van Belle J.,de Zeeuw.Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder.Biological Psychiatry. 2011;69:1178-1184.
22. Erhardt D.,Epstein J. N.,Conners C. K.,Parker J. D. A.,Sitarenios G.Self-ratings of ADHD symptoms in adults II: Reliability, validity, and diagnostic sensitivity.Journal of Attention Disorders. 1999;3:153-158.
23. Faraone S. V.,Biederman J.Do attention deficit hyperactivity disorder and major depression share familial risk factors?.Journal of Nervous and Mental Disease. 1997;185:533-541.
24. Faraone S. V.,Biederman J.,Mick E.The age dependant decline of attention-deficit/hyperactivity disorder: A meta-analysis of follow-up studies.Psychological Medicine. 2006;36:159-165.
25. Faraone S. V.,Doyle A. E.Genetic influences on attention deficit hyperactivity disorder.Current Psychiatry Reports. 2000;2:143-146.
26. Frazier T. W.,Demaree H. A.,Youngstrom E. A.Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder.Neuropsychology. 2004;18:543-555.
27. Freitag C. M.,Rohde L. A.,Lempp T.,Romanos M.Phenotypic and measurement influences on heritability estimates in childhood ADHD.European Child & Adolescent Psychiatry. 2010;19:311-323.
28. Goodman R.The strengths and difficulties questionnaire: A research note.Journal of Child Psychology and Psychiatry and Allied Disciplines. 1997;38:581-586.
29. Goodman R.,Stevenson J.A twin study of hyperactivity 2: The etiological role of genes, family relationships and perinatal adversity.Journal of Child Psychology and Psychiatry and Allied Disciplines. 1989;30:691-709.
30. Goos L. M.,Ezzatian P.,Schachar R.Parent-of-origin effects in attention-deficit hyperactivity disorder.Psychiatry Research. 2007;149:1-9.
31. Goos L. M.,Ragsdale G.Genomic imprinting. Wilkins J. F., ed. New York, NY: Landes Bioscience and Springer Science + Business Media, LLC; 2008:71-88.
32. Goos L. M.,Schachar R.,Crosbie J.,Payne S.Validation and extension of the endophenotype model in ADHD patterns of inheritance in a family study of inhibitory control.American Journal of Psychiatry. 2009;166:711-717.
33. Goos L.,Silverman I.The influence of genomic imprinting on brain development and behavior.Evolution and Human Behaviour. 2001;22:385-507.
34. Hawi Z.,Kent L.,Hill M.,Anney R. J.,Brookes K. J.,Barry E.,. Gill M.ADHD and DAT1: Further evidence of paternal over-transmission of risk alleles and haplotype.American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 153B. 2009;:97-102.
35. Hawi Z.,Sheehan K.,Conroy J.,Lowe N.,Kirley A.,Seguardo R.,. Gill M.Preferential transmission of paternal alleles at risk genes in ADHD.American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 138B. 2005;:56-57.
36. Jester J. M.,Nigg J. T.,Puttler L. I.,Long J. C.,Fitzgerald H. E.,Zucker R. A.Intergenerational transmission of neuropsychological executive functioning.Brain and Cognition. 2009;70:145-153.
37. Kendler K. S.,Neale M. C.Endophenotype: A conceptual analysis.Molecular Psychiatry. 2010;15:789-797.
38. Kim J. W.,Waldman I. D.,Faraone S. V.,Biederman J.,Doyle A. E.,Purcell S.,. Smoller J. W.Investigation of parent-of-origin effects in ADHD candidate genes.American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 144B. 2007;:776-780.
39. Kooij J. J. S.,Boonstra A. M.,Swinkels S. H. N.,Bekker E. B.,de Noord I.,Buitelaar J. K.Reliability, validity, and utility of instruments for self-report and informant report concerning symptoms of ADHD in adult patients.Journal of Attention Disorders. 2008;11:445-458.
40. Kooij J. J. S.,Buitelaar J. K.,van den Oord E. J.,Furer J. W.,Rijnders C. A. T.,Hodiamont P. P. G.Internal and external validity of attention-deficit/hyperactivity disorder in a population-based sample of adults.Psychological Medicine. 2005;35:817-827.
41. Laurin N.,Feng Y.,Ickowicz A.,Pathare T.,Malone M.,Tannock R.,. Barr C. L.No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorder.Molecular Psychiatry. 2007;12:226-229.
42. Lavalaye J.,Booij J.,Reneman L.,Habraken J. B. A.,van Royen E. A.Effect of age and gender on dopamine transporter imaging with [123{pipe}]FP-CIT SPET in healthy volunteers.European Journal of Nuclear Medicine. 2000;27:867-869.
43. Lewis P. A.,Miall R. C.Distinct systems for automatic and cognitively controlled time measurement: Evidence from neuroimaging.Current Opinion in Neurobiology. 2003;13:250-255.
44. Lichter D. G.,Jackson L. A.,Schachter M.Clinical evidence of genomic imprinting in Tourette's Syndrome.Neurology. 1995;45:924-928.
45. Martinussen R.,Hayden J.,Hogg-Johnson S.,Tannock R.A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent Psychiatry. 2005;44:377-384.
46. McMahon F. J.,Stine O. C.,Meyers D. A.,Simpson S. G.,DePaulo J. R.Patterns of maternal transmission in bipolar affective disorder.American Journal of Human Genetics. 1995;56:1277-1286.
47. Minde K.,Eakin L.,Hechtman L.,Ochs E.,Bouffard R.,Greenfield B.,Looper K.The psychosocial functioning of children and spouses of adults with ADHD.Journal of Child Psychology and Psychiatry and Allied Disciplines. 2003;44:637-646.
48. Nazari M. A.,Berquin P.,Missonnier P.,Aarabi A.,Debatisse D.,De Broca A.,Walloi F.Visual sensory processing deficit in the occipital region in children with attention-deficit/hyperactivity disorder as revealed by the event-related potentials during cued continuous performance test.Clinical Neuropsychology. 2010;40:137-149.
49. Neale B. M.,Medland S.,Ripke S.,Anney R. J. L.,Asherson P.,Buitelaar J.Case-control genome-wide association study of attention-deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent Psychiatry. 2010;49:906-920.
50. Nigg J. T.,Blaskey L. G.,Stawicki J. A.,Sachek J.Evaluating the endophenotype model of ADHD neuropsychological deficit: Results for parents and siblings of children with ADHD combined and inattentive subtypes.Journal of Abnormal Psychology. 2004;113:614-625.
51. Nigg J. T.,Swanson J. M.,Hinshaw S. P.Covert visual spatial attention in boys with attention deficit hyperactivity disorder: Lateral effects, methylphenidate response and results for parents.Neuropsychologia. 1997;35:165-176.
52. Nikolas M. A.,Burt S. A.Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: A meta-analysis.Journal of Abnormal Psychology. 2010;119:1-17.
53. Preacher K. J.,Hayes A. F.SPSS and SAS procedures for estimating indirect effects in simple mediation models.Behavior Research Methods, Instruments, & Computers. 2004;36:717-731.
54. Quist J. F.,Barr C. L.,Schachar R.,Roberts W.,Malone M.,Tannock R.,. Kennedy J. L.The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder.Molecular Psychiatry. 2003;8:98-102.
55. Ramsden S.,Richardson F. M.,Josse G.,Thomas M. S. C.,Ellis C.,Shakeshaft C.,Price C. J.Verbal and non-verbal intelligence changes in the teenage brain.Nature. 2011;:.
56. Rhee S. H.,Waldman I. D.,Hay D. A.,Levy F.Sex differences in genetic and environmental influences on DSM-III-R attention-deficit/hyperactivity disorder.Journal of Abnormal Psychology. 1999;108:24-41.
57. Rommelse N. N. J.,Altink M. E.,Oosterlaan J.,Beem L.,Buschgens C. J. M.,Buitelaar J.,Sergeant J. A.Speed, variability, and timing of motor output in ADHD: Which measures are useful for endophenotypic research?.Behavior Genetics. 2008;38:121-132.
58. Rommelse N. N. J.,Altink M. E.,Oosterlaan J.,Buschgens C. J. M.,Buitelaar J.,De Sonneville L. M. J.,Sergeant J. A.Motor control in children with ADHD and non-affected siblings: Deficits most pronounced using the left hand.Journal of Child Psychology and Psychiatry. 2007;48:1071-1079.
59. Rommelse N. N. J.,Altink M. E.,Oosterlaan J.,Buschgens C. J. M.,Buitelaar J.,Sergeant J. A.Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families.Psychological Medicine. 2008;38:1595-1606.
60. Rommelse N. N. J.,Arias-Vasquez A.,Altink M. E.,Buschgens C. J. M.,Fliers E.,Asherson P.,. Franke B.Neuropsychological endophenotype approach to genome-wide linkage analysis identifies susceptibility loci for ADHD on 2q21.1 and 13q12.11.American Journal of Human Genetics. 2008;83:294-294.
61. Rommelse N. N. J.,Oosterlaan J.,Buitelaar J.,Faraone S. V.,Sergeant J. A.Time reproduction in children with ADHD and their nonaffected siblings.Journal of the American Academy of Child and Adolescent Psychiatry. 2007;46:582-590.
62. Rubin D. B.Multiple imputation for nonresponse in surveys. New York, NY: Wiley; 1987:.
63. Schumann C. M.,Hamstra J.,Goodlin-Jones B. L.,Kwon H.,Reiss A. L.,Amaral D. G.Hippocampal size positively correlates with verbal IQ in male children.Hippocampus. 2007;17:486-493.
64. Seidman L. J.,Biederman J.,Faraone S. V.,Wever W.,Ouellette C.Toward defining a neuropsychology of attention deficit-hyperactivity disorder: Performance of children and adolescents from a large clinically referred sample.Journal of Consulting and Clinical Psychology. 1997;65:150-160.
65. Seidman L. J.,Biederman J.,Monuteaux M. C.,Valera E.,Doyle A. E.,Faraone S. V.Impact of gender and age on executive functioning: Do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?.Developmental Neuropsychology. 2005;27:79-105.
66. Shete S.,Amos C. I.Testing for genetic linkage in families by a variance-component approach in the presence of genomic imprinting.American Journal of Human Genetics. 2002;70:751-757.
67. Smoller J. W.,Biederman J.,Arbeitman L.,Doyle A. E.,Fagerness J.,Perlis R. H.,. Faraone S. V.Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD.Biological Psychiatry. 2006;59:460-467.
68. Sonuga-Barke E.,Bitsakou P.,Thompson M.Beyond the dual pathway model: Evidence for the dissociation of timing, inhibitory and delay-related impairment in Attention Deficit/Hyperactivity Disorder.Journal of the American Academy of Child & Adolescent Psychiatry. 2010;49:345-355.
69. Sprich S.,Biederman J.,Crawford M. H.,Mundy E.,Faraone S. V.Adoptive and biological families of children and adolescents with ADHD.Journal of the American Academy of Child and Adolescent Psychiatry. 2000;39:1432-1437.
70. Takeda T.,Stotesbery K.,Power T.,Ambrosini P. J.,Berrettini W.,Hakonarson H.,Elia J.Parental status and its association with proband ADHD subtype and severity.Journal of Pediatrics. 2010;157:995-1000.
71. Taylor E. A.Childhood hyperactivity.British Journal of Psychiatry. 1986;149:562-573.
72. Thapar A.,Harrington R.,Ross K.,McGuffin P.Does the definition of ADHD affect heritability?.Journal of the American Academy of Child and Adolescent Psychiatry. 2000;39:1528-1536.
73. Thapar A.,Hervas A.,Mcguffin P.Childhood hyperactivity scores are highly heritable and show sibling competition effects-Twin study evidence.Behavior Genetics. 1995;25:537-544.
74. Wåhlstedt C.,Thorell L. B.,Bohlin G.Heterogeneity in ADHD: Neuropsychological pathways, comorbidity and symptom domains.Journal of Abnormal Child Psychology. 2009;37:551-564.
75. Walters J. T. R.,Owen M. J.Endophenotypes in psychiatric genetics.Molecular Psychiatry. 2007;12:886-890.
76. Willcutt E. G.,Doyle A. E.,Nigg J. T.,Faraone S. V.,Pennington B.Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review.Biological Psychiatry. 2005;57:1336-1346.
77. Xie Y.,Chen Y. A.,De Bellis M. D.The relationship of age, gender, and IQ with the brainstem and thalamus in healthy children and adolescents: A magnetic resonance imaging volumetric study.Journal of Child Neurology. 2011;:.