A synthetic manassantin a derivative inhibits hypoxia-inducible factor 1 and tumor growth

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Lang, Liwei ^a,b   Liu, Xiaoyu ^a   Li, Yan ^a   Zhou, Qing ^a   Xie, Ping ^a   Yan, Chunhong ^b   Chen, Xiaoguang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS(3'' METHOXY 4'' PHENYL 7''',8''',3''',4''' DIMETHOXY 7''' HYDROXY 8''' METHYLPHENYLETHANE)ETHER; GEMCITABINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; JYJ 5802; JYJ 5807; LIGNAN DERIVATIVE; LXY 6006; LXY 6022; MANASSANTIN A; MANASSANTIN A DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG; XPS 1801; XPS 1838; LIGNAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOACCUMULATION; BREAST TUMOR; CANCER CELL LINE; CANCER INHIBITION; CELL NUCLEUS; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; LUNG TUMOR; MOUSE; NONHUMAN; PANCREAS TUMOR; STEREOCHEMISTRY; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BAGG ALBINO MOUSE; CELL CYCLE CHECKPOINT; CELL HYPOXIA; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL HYPOXIA; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGNANS; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; PACLITAXEL; TRANSCRIPTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84903388421     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099584     Document Type: Article

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