Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 12, 2012, Pages 2170-2179

  Zhou, Qing ^a   Li, Yan ^a   Jin, Jing ^a   Lang, Liwei ^a   Zhu, Zhixiang ^a   Fang, Weishuo ^a   Chen, Xiaoguang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Anti resistance activity; Apoptosis; Lx2 32c; Microtubule; Taxane

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; LX 2 32C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; TAXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA FRAGMENTATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME DEGRADATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE ASSEMBLY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; BRIDGED COMPOUNDS; CASPASE 3; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYTOCHROMES C; DNA FRAGMENTATION; DRUG RESISTANCE, NEOPLASM; FAS LIGAND PROTEIN; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, NUDE; MICROTUBULES; MITOCHONDRIA; NEOPLASMS; PACLITAXEL; POLY(ADP-RIBOSE) POLYMERASES; POLYMERIZATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TAXOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84871558376     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00513     Document Type: Article

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