Neuronal Responses to Hypocretin/Orexin

Contemporary Clinical Neuroscience

Volumn , Issue , 2005, Pages 45-60

  van den Pol, Anthony N ^a   Acuna Goycolea, Claudio ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dorsal Raphe; Dorsal Raphe Nucleus; Excitatory Action; Lateral Hypothalamus; Solitary Tract

Indexed keywords

EID: 84903363569     PISSN: 2627535X     EISSN: 26275341     Source Type: Book Series    
DOI: 10.1385/1-59259-950-8:45     Document Type: Chapter

References (58)

1. de Lecea, L., Kilduff, T.S., Peyron, C., et al. (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U S A. 95, 322–327.
2. Sakurai, T., Amemiya, A., Ishii, M., et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573–585.
3. Peyron, C., Tighe, D.K., van den Pol, A.N., et al. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18, 9996–10015.
4. van den Pol, A.N. (1999) Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. J. Neurosci. 19, 3171–3182.
5. Marcus, J.N., Aschkenasi, C.J., Lee, C.E., et al. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435, 6–25.
6. Lin, L., Faraco, J., Li, H., et al. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365–376.
7. Chemelli, R.M., Willie, J.T., Sinton, C.M., et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437–451.
8. Thannickal, T.C., Moore, R.Y., Nienhuis, R., et al. (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27, 469–474.
9. Peyron, C., Faraco, J., Rogers, W., et al. (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med. 6, 991–997.
10. Nishino, S., Ripley, B., Overeem, S., Lammers, G.J., and Mignot, E. (2000) Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355, 39–40.
11. Haynes, A.C., Jackson, B., Overend, P., et al. (1999) Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20, 1099–1105.
12. Cai, X.J., Widdowson, P.S., Harrold, J., et al. (1999) Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 48, 2132–2137.
13. Hara, J., Beuckmann, C.T., Nambu, T., et al. (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30, 345–354.
14. van den Pol, A.N., Gao, X.B., Obrietan, K., Kilduff, T.S., and Belousov, A.B. (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 18, 7962–7971.
15. van den Pol, A.N., Patrylo, P.R., Ghosh, P.K., and Gao, X.B. (2001) Lateral hypothalamus— early developmental expression and response to hypocretin (orexin). J. Comp. Neurol. 433, 349–363.
16. Li, Y., Gao, X.B., Sakurai, T., and van den Pol, A.N. (2002) Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron—a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36, 1–20.
17. Bayer, L., Eggermann, E., Saint-Mleux, B., et al. (2002) Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons. J. Neurosci. 22, 7835–7839.
18. Yang, B., Samson, W.K., and Ferguson, A.V. (2003) Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C. J. Neurosci. 23, 6215–6222.
19. van den Top, M., Nolan, M.F., Lee, K., et al. (2003) Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones. J. Physiol. 549, 809–821
20. Grudt, T.J., van den Pol, A.N., and Perl, E.R. (2002) Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activty in rat. J. Physiol. 538, 517–525.
21. Eriksson, K.S., Sergeeva, O., Brown, R.E., and Haas, H.L. (2001) Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J. Neurosci. 21, 9273–9279.
22. Hwang, L.-L., Chen, C., and Dun, N.J. (2001) Mechanisms of orexin-induced depolarizations in rat dorsal motor nucleus of vagus neurons in vitro. J. Physiol. 537, 511–520.
23. Wu, M., Zhang, Z., Leranth, C., Xu, C., van den Pol, A.N., and Alreja, M. (2002) Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition. J. Neurosci. 22, 7754–7765.
24. Liu, R.J., van den Pol, A.N., and Aghajanian, G.K. (2002) Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J. Neurosci. 22, 9453–9464.
25. Wu, M., Zaborszky, L., Hajszan, T., van den Pol, A.N., and Alreja, M. (2004) Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons. J. Neurosci. 24, 3527–3536.
26. van den Pol, A.N., Ghosh, P.K., Liu, R., Li, Y., Aghajanian, G.K., and Gao, X.B. (2002) Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J. Physiol. 541, 169–185.
27. + conductances. J. Neurophysiol. 89, 2167–2175.
28. Agahjanian, G. and Vandermaelen, C.P. (1982) Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure. J. Neurosci. 2, 1786–1792.
29. Brown, R.E., Sergeeva, O.A., Eriksson, K.S., and Haas, H.L. (2002) Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and nora-drenaline). J. Neurosci. 22, 8850–8859.
30. Burlet, S., Tyler, C.J., and Leonard, C.S. (2002) Direct and indirect excitation of laterodorsal tegmental neurons by hypocretin/orexin peptides: implications for wakefulness and narcolepsy. J. Neurosci. 22, 2862–2872.
31. Burdakov, D., Liss, B., and Ashcroft, F.M. (2003) Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger. J. Neurosci. 23, 4951–4957.
32. Ivanov, A. and Aston-Jones, G. (2000) Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. Neuroreport 11, 1755–1758.
33. Brown, R.E., Sergeeva, O., Eriksson, K.S., and Haas, H.L. (2001) Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology 40, 457–459.
34. Horvath, T.L., Peyron, C., Diano, S., et al. (1999) Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J. Comp. Neurol. 415, 145–159.
35. + current in hippocampal pyramidal neurons. Proc. Natl. Acad. Sci. U S A 96, 5662–4667.
36. Kohlmeier, K.A., Inoue, T., and Leonard, C.S. (2004) Hypocretin/orexin signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. J. Neurophysiol. 92, 221–235.
37. 2+ signaling in dopamine neurons of ventral tegmental area. Neuroreport 12, 1885–1889.
38. Smart, D., Jerman, J.C., Brough, S.J., et al. (1999) Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br. J. Pharmacol. 128, 1–3.
39. 2+ influx pathway necessary for coupling to phospholipase C. J. Biol. Chem. 40, 30,806–30,812.
40. Smith, B.N., Davis, S.F., van den Pol, A.N., and Xu, W. (2002) Selective enhancement of excitatory synaptic activity in the rat nucleus tractus solitarius by hypocretin 2. Neuroscience 115, 707–714.
41. Lambe, E.K. and Aghajanian, G.K. (2003) Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron 40, 139–150.
42. Acuna-Goycolea, C., Li, Y., and van den Pol, A.N. (2004) Group 3 metabotropic glutamate receptors maintain tonic inhibition of excitatory synaptic input to hypocretin/orexin neurons. J. Neurosci. 24, 3013–3022.
43. Christie, M.J., Williams, J.T., and North, R.A. (1989) Electrical coupling synchronizes subthresh-old activity in locus coeruleus neurons in vitro from neonatal rats. J. Neurosci. 9, 3584–3589.
44. Usher, M., Cohen, J.D., Servan-Schreiber, D., Rajkowski, J., and Aston-Jones, G. (1999) The role of locus coeruleus in the regulation of cognitive performance. Science 283, 549–554.
45. Logan, S.D., Pickering, A.E., Gibson, I.C., Nolan, M.F., and Spanswick, D. (1996) Electrotonic coupling between rat sympathetic preganglionic neurons in vitro. J. Physiol. 495, 491–502.
46. Hagan, J.J., Leslie, R.A., Patel, S., et al. (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl. Acad. Sci. U S A 96, 10911–10926.
47. Bayer, L., Eggermann, E., Serafin, M., et al. (2001) Orexins (hypocretins) directly excite tuberomammillary neurons. Eur. J. Neurosci. 14, 1571–1575.
48. Panula, P., Yang, H.Y., and Costa, E. (1984) Histamine-containing neurons in the rat hypothalamus. Proc. Natl. Acad. Sci. U S A 81, 2572–2576.
49. Guan, J.L., Uehara, K., Lu, S., et al. (2002) Reciprocal synaptic relationships between orexin-and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation. Int. J. Obesity Relat. Metab. Disord. 26, 1523–1532.
50. van den Pol, A.N., Acuna-Goycolea, C., Clark, R., and Ghosh, P.K. (2004) Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection infection. Neuron 42, 635–652.
51. Eggermann, E., Serafin, M., Bayer, L., et al. (2001) Orexins/hypocretins excite basal forebrain cholinergic neurones. Neuroscience 108, 177–181.
52. Horvath, T.L., Diano, S., and van den Pol, A.N. (1999) Synaptic interaction between hypocretin (orexin) containing neurons and arcuate nucleus NPY-producing cells in rodent and primate—a new hypothalamic circuit implicated in energy homeostasis. J. Neurosci. 19, 1072–1087.
53. van den Top, M., Lee, K., Whyment, A.D., Blanks, A.M., and Spanswick, D. (2004) Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 7, 493–494.
54. Bayer, L., Serafin, M., Eggermann, E., et al. (2004) Postsynaptic action of hypocretin-orexin on sublayer 6b cortical neurons. J. Neurosci. 24, 6760–6764.
55. Haj-Dahmane, S. and Shen, R.Y. (2005) Wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J. Neurosci. 25, 896–905.
56. Li, Y. and van den Pol, A.N. (2005) Direct and indirect inhibition by catecholamines of hypocretin/ orexin neurons. J. Neurosci. 25, 173–183.
57. Acuna-Goycolea, C. and van den Pol, A.N. (2004) Glucagon-like peptide 1 excites hypocretin/ orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal. J. Neurosci. 24, 8141–8152.
58. Fu, L.Y., Acuna-Goycolea, C., and van den Pol, A.N. (2004) Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J. Neurosci. 24, 8741–8751.