Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice

Neuron

Volumn 40, Issue 1, 2003, Pages 139-150

  Lambe, Evelyn K ^a   Aghajanian, George K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; NEUROTRANSMITTER; OREXIN;

ALERTNESS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; NERVE CELL MEMBRANE POTENTIAL; NERVE FIBER; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPIKE WAVE; SYNAPTIC TRANSMISSION; THALAMOCORTICAL TRACT; WAKEFULNESS;

EID: 0141638451     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(03)00598-1     Document Type: Article

References (48)

1. Bayer L., Eggermann E., Saint-Mleux B., Machard D., Jones B.E., Muhlethaler M., Serafin M. Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons. J. Neurosci. 22:2002;7835-7839.
2. Berendse H.W., Groenewegen H.J. Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat. Neuroscience. 42:1991;73-102.
3. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y.et al. Narcolepsy in orexin knockout mice. molecular genetics of sleep regulation Cell. 98:1999;437-451.
4. Deschenes M., Bourassa J., Parent A. Striatal and cortical projections of single neurons from the central lateral thalamic nucleus in the rat. Neuroscience. 72:1996;679-687.
5. Fadel J., Deutch A.Y. Anatomical substrates of orexin-dopamine interactions. lateral hypothalamic projections to the ventral tegmental area Neuroscience. 111:2002;379-387.
6. Fadel J., Bubser M., Deutch A.Y. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J. Neurosci. 22:2002;6742-6746.
7. Giacchino J.L., Henriksen S.J. Opioid effects on activation of neurons in the medial prefrontal cortex. Prog. Neuropsychopharmacol. Biol. Psychiatry. 22:1998;1157-1178.
8. Groenewegen H.J., Berendse H.W. The specificity of the 'nonspecific' midline and intralaminar thalamic nuclei. Trends Neurosci. 17:1994;52-57.
9. Groenewegen H.J., Uylings H.B. The prefrontal cortex and the integration of sensory, limbic and autonomic information. Prog. Brain Res. 126:2000;3-28.
10. Gutnick M.J., Prince D.A. Thalamocortical relay neurons. antidromic invasion of spikes from a cortical epileptogenic focus Science. 176:1972;424-426.
11. Haas K., Sin W.C., Javaherian A., Li Z., Cline H.T. Single-cell electroporation for gene transfer in vivo. Neuron. 29:2001;583-591.
12. Haas K., Jensen K., Sin W.C., Foa L., Cline H.T. Targeted electroporation in Xenopus tadpoles in vivo-from single cells to the entire brain. Differentiation. 70:2002;148-154.
13. Helmchen F., Svoboda K., Denk W., Tank D.W. In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nat. Neurosci. 2:1999;989-996.
14. Hofle N., Paus T., Reutens D., Fiset P., Gotman J., Evans A.C., Jones B.E. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17:1997;4800-4808.
15. Jones E.G. The thalamic matrix and thalamocortical synchrony. Trends Neurosci. 24:2001;595-601.
16. Kiyashchenko L.I., Mileykovskiy B.Y., Maidment N., Lam H.A., Wu M.F., John J., Peever J., Siegel J.M. Release of hypocretin (orexin) during waking and sleep states. J. Neurosci. 22:2002;5282-5286.
17. Kovalchuk Y., Eilers J., Lisman J., Konnerth A. NMDA receptor-mediated subthreshold Ca (2+) signals in spines of hippocampal neurons. J. Neurosci. 20:2000;1791-1799.
18. Lambe E.K., Aghajanian G.K. The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. J. Neurosci. 21:2001;9955-9963.
19. Lambe E.K., Picciotto M.R., Aghajanian G.K. Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology. 28:2003;216-225.
20. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:1999;365-376.
21. Mainen Z.F., Malinow R., Svoboda K. Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature. 399:1999;151-155.
22. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435:2001;6-25.
23. Marek G.J., Wright R.A., Gewirtz J.C., Schoepp D.D. A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex. Neuroscience. 105:2001;379-392.
24. Marini G., Pianca L., Tredici G. Thalamocortical projection from the parafascicular nucleus to layer V pyramidal cells in frontal and cingulate areas of the rat. Neurosci. Lett. 203:1996;81-84.
25. McCormick D.A., Bal T. Sleep and arousal. thalamocortical mechanisms Annu. Rev. Neurosci. 20:1997;185-215.
26. McCormick D.A., Contreras D. On the cellular and network bases of epileptic seizures. Annu. Rev. Physiol. 63:2001;815-846.
27. McGinty J.F., van der Kooy D., Bloom F.E. The distribution and morphology of opioid peptide immunoreactive neurons in the cerebral cortex of rats. J. Neurosci. 4:1984;1104-1117.
28. Naumann A., Bierbrauer J., Przuntek H., Daum I. Attentive and preattentive processing in narcolepsy as revealed by event-related potentials (ERPs). Neuroreport. 12:2001;2807-2811.
29. Oertner T.G., Sabatini B.L., Nimchinsky E.A., Svoboda K. Facilitation at single synapses probed with optical quantal analysis. Nat. Neurosci. 5:2002;657-664.
30. Paus T., Koski L., Caramanos Z., Westbury C. Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex. a review of 107 PET activation studies Neuroreport. 9:1998;R37-R47.
31. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18:1998;9996-10015.
32. Peyron C., Faraco J., Rogers W., Ripley B., Overeem S., Charnay Y., Nevsimalova S., Aldrich M., Reynolds D., Albin R.et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med. 6:2000;991-997.
33. Pinault D. Backpropagation of action potentials generated at ectopic axonal loci. hypothesis that axon terminals integrate local environmental signals Brain Res. Brain Res. Rev. 21:1995;42-92.
34. Pinault D., Pumain R. Antidromic firing occurs spontaneously on thalamic relay neurons. triggering of somatic intrinsic burst discharges by ectopic action potentials Neuroscience. 31:1989;625-637.
35. Rieger M., Mayer G., Gauggel S. Attention deficits in patients with narcolepsy. Sleep. 26:2003;36-43.
36. Ripley B., Overeem S., Fujiki N., Nevsimalova S., Uchino M., Yesavage J., Di Monte D., Dohi K., Melberg A., Lammers G.J.et al. CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. Neurology. 57:2001;2253-2258.
37. Saito T., Nakatsuji N. Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev. Biol. 240:2001;237-246.
38. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S.et al. Orexins and orexin receptors. a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell. 92:1998;573-585.
39. Steriade M., Curro Dossi R., Contreras D. Electrophysiological properties of intralaminar thalamocortical cells discharging rhythmic (approximately 40 HZ) spike-bursts at approximately 1000 HZ during waking and rapid eye movement sleep. Neuroscience. 56:1993;1-9.
40. Sutcliffe J.G., de Lecea L. The hypocretins. setting the arousal threshold Nat. Rev. Neurosci. 3:2002;339-349.
41. Tanaka E., North R.A. Opioid actions on rat anterior cingulate cortex neurons in vitro. J. Neurosci. 14:1994;1106-1113.
42. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., Siegel J.M. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 27:2000;469-474.
43. Trivedi P., Yu H., MacNeil D.J., Van der Ploeg L.H., Guan X.M. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett. 438:1998;71-75.
44. Wu M.F., John J., Maidment N., Lam H.A., Siegel J.M. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283:2002;R1079-R1086.
45. Yamasaki H., LaBar K.S., McCarthy G. Dissociable prefrontal brain systems for attention and emotion. Proc. Natl. Acad. Sci. USA. 99:2002;11447-11451.
46. Yoshida Y., Fujiki N., Nakajima T., Ripley B., Matsumura H., Yoneda H., Mignot E., Nishino S. Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur. J. Neurosci. 14:2001;1075-1081.
47. Yuste R., Denk W. Dendritic spines as basic functional units of neuronal integration. Nature. 375:1995;682-684.
48. Zubieta J.K., Smith Y.R., Bueller J.A., Xu Y., Kilbourn M.R., Jewett D.M., Meyer C.R., Koeppe R.A., Stohler C.S. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science. 293:2001;311-315.