Genetic variants in PCSK1 gene are associated with the risk of coronary artery disease in type 2 diabetes in a Chinese Han population: A case control study

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Wei, Xiaowei ^a   Ma, Xiaowei ^a   Lu, Ran ^a   Bai, Ge ^a   Zhang, Jianwei ^a   Deng, Ruifen ^a   Gu, Nan ^a   Feng, Nan ^a   Guo, Xiaohui ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOMINANT INHERITANCE; FEMALE; GENDER; GENE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PCSK1 GENE; RECESSIVE INHERITANCE; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

AGED; CASE-CONTROL STUDIES; CHINA; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPROTEIN CONVERTASE 1;

EID: 84900308487     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087168     Document Type: Article

References (19)

1. Kannel WB, McGee DL (1979) Diabetes and cardiovascular risk factors: the Framingham study. Circulation 59: 8-13. (Pubitemid 9082394)
2. BARI Investigators (2007) The final 10-year follow-up results from the BARI randomized trial. J Am Coll Cardiol 49: 1600-1606.
3. Hayden MR, Tyagi SC, Kolb L, Sowers JR, Khanna R (2005) Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. Cardiovasc Diabetol 4: 4.
4. Kaplan M, Aviram M, Hayek T (2012) Oxidative stress and macrophage foam cell formation during diabetes mellitus-induced atherogenesis: role of insulin therapy. Pharmacol Ther 136: 175-185.
5. Anagnostis P, Athyros VG, Adamidou F, Panagiotou A, Kita M, et al. (2011) Glucagon-like peptide-1-based therapies and cardiovascular disease: looking beyond glycaemic control. Diabetes Obes Metab 13: 302-312.
6. Schneider H, Shaw J, Zimmet P (2003) Guidelines for the detection of diabetes mellitus-diagnostic criteria and rationale for screening. Clin Biochem Rev 24: 77-80.
7. Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, et al. (1997) Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16: 303-306. (Pubitemid 27280217)
8. Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, et al. (2003) Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest 112: 1550-1560. (Pubitemid 38056281)
9. Farooqi IS, Volders K, Stanhope R, Heuschkel R, White A, et al. (2007) Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. J Clin Endocrinol Metab 92: 3369- 3373.
10. Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ (2007) A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alphacells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes 56: 2744-2752. (Pubitemid 350044917)
11. Yu Q, Gao F, Ma XL (2011) Insulin says NO to cardiovascular disease. Cardiovasc Res 89: 516-524.
12. Zethelius B, Byberg L, Hales CN, Lithell H, Berne C (2002) Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year followup study. Circulation 105: 2153-2158. (Pubitemid 34517158)
13. Zethelius B, Lithell H, Hales CN, Berne C (2005) Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp. Diabetologia 48: 862-867. (Pubitemid 40767978)
14. Chang YC, Chiu YF, Shih KC, Lin MW, Sheu WH, et al. (2010) Common PCSK1 haplotypes are associated with obesity in the Chinese population. Obesity (Silver Spring) 18: 1404-1409.
15. Mbikay M, Sirois F, Nkongolo KK, Basak A, Chretien M (2011) Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity. Mol Genet Metab 104: 682-687.
16. Qi Q, Li H, Loos RJ, Liu C, Hu FB, et al. (2010) Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. PLoS One 5: e10590.
17. Heni M, Haupt A, Schafer SA, Ketterer C, Thamer C, et al. (2010) Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion. BMC Med Genet 11: 86.
18. Gjesing AP, Vestmar MA, Jorgensen T, Heni M, Holst JJ, et al. (2011) The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status. PLoS One 6: e23907.
19. Sirois F, Kaefer N, Currie KA, Chretien M, Nkongolo KK, et al. (2012) Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample. J Community Genet 3: 319-322.