A novel PPARgamma agonist monascin's potential application in diabetes prevention

Food and Function

Volumn 5, Issue 7, 2014, Pages 1334-1340

  Hsu, Wei Hsuan ^a   Pan, Tzu Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE;

ADVANCED GLYCATION END PRODUCTS; CYTOKINE PRODUCTION; HEPATIC STELLATE CELLS; HYPERCHOLESTEROLEMIA; INSULIN EXPRESSIONS; MONASCUS-FERMENTED PRODUCTS; SECONDARY METABOLITES; TRADITIONAL CHINESE MEDICINE;

INSULIN;

ADVANCED GLYCATION END PRODUCT; ANKAFLAVIN; ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; FUSED HETEROCYCLIC RINGS; INSULIN; MONASCIN; NFE2L2 PROTEIN, RAT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RIBOFLAVIN DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

AGONISTS; ANIMAL; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS; DRUG EFFECTS; HUMAN; LIVER; METABOLISM; MONASCUS; PANCREAS; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; DIABETES MELLITUS; FLAVINS; GLYCOSYLATION END PRODUCTS, ADVANCED; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LIVER; MONASCUS; NF-E2-RELATED FACTOR 2; PANCREAS; PPAR GAMMA; RATS;

EID: 84903276524     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c3fo60575b     Document Type: Review

References (50)

1. M. van Tieghem Monascus genre nouvear de l'ondre des Ascomycetes Bull. Soc. Bot. Fr. 1884 31 226 231
2. D. L. Hawksworth J. I. Pit A new taxonomy for Monascus species based on cultural and microscopical characters Aust. J. Bot. 1983 31 51 61
3. T. Akihisa H. Tokuda M. Ukiya A. Kiyota K. Yasukawa N. Sakamoto Y. Kimura T. Suzuki J. Takayasu H. Nishino Anti-tumor initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice) Chem. Biodiversity 2005 2 1305 1309
4. T. Akihisa H. Tokuda K. Yasukawa M. Ukiya A. Kiyota N. Sakamoto T. Suzuki N. Tanabe H. Nishino Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects J. Agric. Food Chem. 2005 53 562 565
5. Y. Kohama S. Matsumoto T. Mimura N. Tanabe A. Inada T. Nakanishi Isolation and identification of hypotensive principles in red mold rice Chem. Pharm. Bull. 1987 35 2484 2489
6. L. Martinkova P. Patakova-Juzlova V. Kren Z. Kucerova V. Havlicek P. Olsovsky O. Hovorka B. Rihova D. Vesely D. Vesela J. Ulrichova V. Prikrylova Biological activities of oligoketide pigments of Monascus purpureus Food Addit. Contam. 1999 16 15 24
7. B. H. Lee W. H. Hsu Y. W. Hsu T. M. Pan Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into D-lactic acid Free Radical Biol. Med. 2013 60 7 16
8. W. H. Hsu B. H. Lee Y. Y. Chang Y. W. Hsu T. M. Pan A novel natural Nrf2 activator with PPAR-gamma agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia Toxicol. Appl. Pharmacol. 2013 272 842 851
9. J. F. Day S. R. Thorpe J. W. Baynes Nonenzymatically glucosylated albumin: in vitro preparation and isolation from normal human serum J. Biol. Chem. 1979 254 595 597
10. C. H. Wu S. M. Huang J. A. Lin G. C. Yen Inhibition of advanced glycation endproduct formation by foodstuffs Food Funct. 2011 2 224 234
11. A. A. Bulhak C. Jung C. C. Ostenson J. O. Lundberg P. O. Sjoquist J. Pernow PPARγ activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-kinas/Akt and NO pathway Am. J. Physiol.: Heart Circ. Physiol. 2009 296 H719 H727
12. W. E. Ackerman X. L. Zhang B. H. Rovin D. A. Kniss Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells Biol. Reprod. 2005 73 527 535
13. S. Hirai N. Takahashi T. Goto S. Lin T. Uemura R. Yu T. Kawada Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies Mediators Inflammation 2010 367838
14. I. Choi Y. Park H. Choi E. H. Lee Anti-adipogenic activity of rutin in 3T3-L1 cells and mice fed with high-fat diet BioFactors 2006 26 273 281
15. C. C. Chuang K. Martinez G. Xie A. Kennedy A. Bumrungpert A. Overman W. Jia M. K. Mclntosh Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α-mediated inflammation and insulin resistance in primary human adipocytes J. Am. Clin. Nutr. 2010 92 1511 1521
16. J. H. Choi A. S. Banks J. L. Estall S. Kajimura P. Bostrom D. Laznik J. L. Ruas M. J. Chalmers T. M. Kamenecka M. Bluher P. R. Griffin B. M. Spiegelman Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5 Nature 2010 466 451 456
17. M. Dubois F. Pattou J. Kerr-Conte V. Gmyr B. Vandewalle P. Desreumaux J. Auwerx K. Schoonjans J. Lefebvre Expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) in normal human pancreatic islet cells Diabetologia 2000 43 1165 1169
18. C. Y. Lin T. Gurlo L. O. Haataja W. A. Hsueh P. C. Butler Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3′-kinase-dependent pathway J. Clin. Endocrinol. Metab. 2005 90 6678 6686
19. J. A. Moibi D. Gupta T. L. Jetton M. Peshavaria R. Desai J. L. Leahy Peroxisome proliferator-activated receptor-γ regulates expression of PDX-1 and NKX6.1 in INS-1 cells Diabetes 2007 56 88 95
20. H. I. Kim J. W. Kim S. H. Kim J. Y. Cha K. S. Kim Y. H. Ahn Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter Diabetes 2000 49 1517 1524
21. N. Irwin J. M. McKinney C. J. Bailey N. H. McClenaghan P. R. Flatt Acute and long-term effects of peroxisome proliferator activated receptor-γ activation on the function and insulin secretory responsiveness of clonal beta-cells Horm. Metab. Res. 2011 43 244 249
22. M. T. Coughlan F. Y. T. Yap D. C. K. Yong S. Andrikopoulos A. Gasser V. Thallas-Bonke D. E. Webster J. I. Miyazaki T. W. Kay R. M. Slattery D. M. Kaye B. G. Drew B. A. Kingwell S. Fourlanos P. H. Groop L. C. Harrison M. Knip J. M. Forbes Advanced glycation end products are direct modulators of beta-cell function Diabetes 2011 60 2523 2532
23. T. Shu Y. Zhu H. Wang Y. Lin Z. Ma X. Han AGEs decrease insulin synthesis in pancreatic beta-cell by repressing PDX-1 protein expression at the post-translational level PLoS One 2011 6 e18782
24. A. Puddu R. Sanguineti A. Durante G. L. Viviani Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15 Regul. Pept. 2012 177 79 84
25. H. Kaneto T. Miyatsuka D. Kawamori PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function Endocr. J. 2008 55 235 252
26. W. H. Hsu B. H. Lee C. H. Li Y. W. Hsu T. M. Pan Monascin and AITC attenuate methylglyoxal-induced PPARgamma phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation J. Agric. Food Chem. 2013 61 5996 6006
27. S. M. Huang C. H. Wu G. C. Yen Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs Mol. Nutr. Food Res. 2006 50 1129 1139
28. N. Shanmugam M. A. Reddy M. Guha R. Natarajan High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells Diabetes 2003 52 1256 1264
29. B. H. Lee W. H. Hsu T. Huang Y. Y. Chang Y. W. Hsu T. M. Pan Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated Wistar rats J. Agric. Food Chem. 2013 61 1288 1298
30. W. H. Hsu B. H. Lee T. H. Liao Y. W. Hsu T. M. Pan Monascus-fermented metabolite monascin suppresses inflammation via PPARγ regulation and JNK inactivation in THP-1 monocytes Food Chem. Toxicol. 2012 50 1178 1186
31. C. P. Lin Y. L. Lin P. H. Huang H. S. Tsai Y. H. Chen Inhibition of endothelial adhesion molecule expression by Monascus purpureus-fermented rice metabolites, monacolin K, ankaflavin, and monascin J. Sci. Food Agric. 2011 91 1751 1758
32. Y. C. Shi H. C. Liao T. M. Pan Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans Free Radical Biol. Med. 2012 52 109 117
33. D. V. Chartoumpekis P. G. Ziros A. I. Psyrogiannis A. G. Papavassiliou V. E. Kyriazopoulou G. P. Sykiotis I. G. Habeos Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice Diabetes 2011 60 2465 2473
34. S. K. Singh P. K. Rai D. Jaiswal G. Watal Evidence-based critical evaluation of glycemic potential of Cynodon dactylon J. Evidence-Based Complementary Altern. Med. 2008 5 415 420
35. A. C. Thirone C. Huang A. Klip Tissue-specific roles of IRS proteins in insulin signaling and glucose transport Trends Endocrinol. Metab. 2006 17 72 78
36. K. F. Petersen G. L. Shulman Etiology of insulin resistance Am. J. Med. 2006 119 S10 S16
37. S. L. Abbate J. D. Brunzell Pathophysiology of hyperlipidemia in diabetes mellitus J. Cardiovasc. Pharmacol. 1990 16 S1 S7
38. K. Ravi B. Ramachandran S. Subramanian Protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin induced diabetic rats Biol. Pharm. Bull. 2004 27 1212 1217
39. A. T. Cheung J. Wang D. Ree J. K. Koll M. Bryer-Ash Tumor necrosis factor-α induces hepatic insulin resistance in obese zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase Diabetes 2000 49 810 819
40. B. H. Lee W. H. Hsu T. H. Liao T. M. Pan The Monascus metabolite monascin against TNF-α-induced insulin resistance via suppressing PPARγ phosphorylation in C2C12 myotubes Food Chem. Toxicol. 2012 49 2609 2617
41. X. Jia D. J. Olson A. R. Ross L. Wu Structural and functional changes in human insulin induced by methylglyoxal FASEB J. 2006 20 1555 1557
42. A. Riboulet-Chavey A. Pierron I. Durand J. Murdaca J. Giudicelli E. Van Obberghen Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species Diabetes 2006 55 1289 1299
43. F. Fiory A. Lombardi C. Miele J. Giudicelli F. Beguinot E. Van Obberghen Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E Diabetologia 2011 54 2941 2952
44. A. Dhar K. M. Desai L. Wu Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats Br. J. Pharmacol. 2010 159 166 175
45. A. Dhar I. Dhar B. Jiang K. M. Desai L. Wu Chronic methylglyoxal infusion by minipump causes pancreatic β-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats Diabetes 2011 60 899 908
46. B. H. Lee W. H. Hsu T. Huang Y. Y. Chang Y. W. Hsu T. M. Pan Monascin improves diabetes and dyslipidemia by regulating PPARgamma and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mice Food Funct. 2013 4 950 959
47. H. Fehrenbach R. Weiskirchen M. Kasper A. M. Gressner Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts Hepatology 2001 34 943 952
48. E. L. M. Guimaraes C. Empsen A. Geerts L. A. van Grunsven Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells J. Hepatol. 2010 52 389 397
49. T. M. Buetler E. Leclerc A. Baumeyer H. Latado J. Newell O. Adolfsson V. Parisod J. Richoz S. Maurer F. Foata D. Piguet S. Junod C. W. Heizmann T. Delatour N-Carboxymethyllysine modified proteins are unable to bind to RAGE and activate an inflammatory response Mol. Nutr. Food Res. 2008 52 370 378
50. W. H. Hsu B. H. Lee Y. W. Hsu T. M. Pan Peroxisome proliferator-activated receptor-gamma activators monascin and rosigliatazone attenuate carboxymethyllysine-induced fibrosis in hepatic stellate cells through regulating the oxidative stress pathway but independent of the receptor for advanced glycation endproducts signaling J. Agric. Food Chem. 2013 61 6873 6879