-
2
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
-
DOI 10.1038/363558a0
-
Ionov Y, Peinado MA, Malkhosyan S, et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature. 1993;363:558-61. (Pubitemid 23186645)
-
(1993)
Nature
, vol.363
, Issue.6429
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.A.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.5
-
3
-
-
0027145633
-
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
-
DOI 10.1016/0092-8674(93)90330-S
-
Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell. 1993;75:1215-25. (Pubitemid 24006117)
-
(1993)
Cell
, vol.75
, Issue.6
, pp. 1215-1225
-
-
Leach, F.S.1
Nicolaides, N.C.2
Papadopoulos, N.3
Liu, B.4
Jen, J.5
Parsons, R.6
Peltomaki, P.7
Sistonen, P.8
Aaltonen, L.A.9
Nystrom-Lahti, M.10
Guan, X.-Y.11
Zhang, J.12
Meltzer, P.S.13
Yu, J.-W.14
Kao, F.-T.15
Chen, D.J.16
Cerosaletti, K.M.17
Fournier, R.E.K.18
Todd, S.19
-
4
-
-
0027263363
-
Genetic mapping of a locus predisposing to human colorectal cancer
-
Peltomaki P, Aaltonen LA, Sistonen P, et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science. 1993;260:810-2. (Pubitemid 23167610)
-
(1993)
Science
, vol.260
, Issue.5109
, pp. 810-812
-
-
Peltomaki, P.1
Aaltonen, L.A.2
Sistonen, P.3
Pylkkanen, L.4
Mecklin, J.-P.5
Jarvinen, H.6
Green, J.S.7
Jass, J.R.8
Weber, J.L.9
Leach, F.S.10
Petersen, G.M.11
Hamilton, S.R.12
De La, C.A.13
Vogelstein, B.14
-
5
-
-
0027158031
-
Clues to the pathogenesis of familial colorectal cancer
-
Aaltonen LA, Peltomaki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science. 1993;260:812-6. (Pubitemid 23167611)
-
(1993)
Science
, vol.260
, Issue.5109
, pp. 812-816
-
-
Aaltonen, L.A.1
Peltomaki, P.2
Leach, F.S.3
Sistonen, P.4
Pylkkanen, L.5
Mecklin, J.-P.6
Jarvinen, H.7
Powell, S.M.8
Jen, J.9
Hamilton, S.R.10
Petersen, G.M.11
Kinzler, K.W.12
Vogelstein, B.13
De La, C.A.14
-
6
-
-
17944362664
-
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
-
Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med. 2005;352:1851-60.
-
(2005)
N Engl J Med
, vol.352
, pp. 1851-1860
-
-
Hampel, H.1
Frankel, W.L.2
Martin, E.3
-
7
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
DOI 10.1073/pnas.95.12.6870
-
Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A. 1998;95:6870-5. (Pubitemid 28278073)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.12
, pp. 6870-6875
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
Graff, J.R.4
Ahuja, N.5
Issa, J.-P.J.6
Markowitz, S.7
Willson, J.K.V.8
Hamilton, S.R.9
Kinzler, K.W.10
Kane, M.F.11
Kolodner, R.D.12
Vogelstein, B.13
Kunkel, T.A.14
Baylin, S.B.15
-
8
-
-
0033587747
-
CpG island methylator phenotype in colorectal cancer
-
DOI 10.1073/pnas.96.15.8681
-
Toyota M, Ahuja N, Ohe-Toyota M, et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A. 1999;96:8681-6. (Pubitemid 29354851)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.15
, pp. 8681-8686
-
-
Toyota, M.1
Ahuja, N.2
Ohe-Toyota, M.3
Herman, J.G.4
Baylin, S.B.5
Issa, J.-P.J.6
-
9
-
-
0037083484
-
Immunohistochemistry versus microsatellite instability testing in phenotyping coloreetal tumors
-
DOI 10.1200/JCO.20.4.1043
-
Lindor NM, Burgart LJ, Leontovich O, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002;20:1043-8. (Pubitemid 34141849)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.4
, pp. 1043-1048
-
-
Lindor, N.M.1
Burgart, L.J.2
Leontovich, O.3
Goldberg, R.M.4
Cunningham, J.M.5
Sargent, D.J.6
Walsh-Vockley, C.7
Petersen, G.M.8
Walsh, M.D.9
Leggett, B.A.10
Young, J.P.11
Barker, M.A.12
Jass, J.R.13
Hopper, J.14
Gallinger, S.15
Bapat, B.16
Redston, M.17
Thibodeau, S.N.18
-
10
-
-
20544437157
-
BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes
-
DOI 10.1038/sj.onc.1208569
-
Domingo E, Niessen RC, Oliveira C, et al. BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes. Oncogene. 2005;24:3995-8. (Pubitemid 40896411)
-
(2005)
Oncogene
, vol.24
, Issue.24
, pp. 3995-3998
-
-
Domingo, E.1
Niessen, R.C.2
Oliveira, C.3
Alhopuro, P.4
Moutinho, C.5
Espin, E.6
Armengol, M.7
Sijmons, R.H.8
Kleibeuker, J.H.9
Seruca, R.10
Aaltonen, L.A.11
Imai, K.12
Yamamoto, H.13
Schwartz Jr., S.14
Hofstra, R.M.W.15
-
11
-
-
1642535480
-
BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, but Not in Hereditary Nonpolyposis Colorectal Cancer
-
DOI 10.1158/1078-0432.CCR-1118-3
-
Deng G, Bell I, Crawley S, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res. 2004;10:191-5. (Pubitemid 38114179)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.1 I
, pp. 191-195
-
-
Deng, G.1
Bell, I.2
Crawley, S.3
Gum, J.4
Terdiman, J.P.5
Allen, B.A.6
Truta, B.7
Sleisenger, M.H.8
Kim, Y.S.9
-
12
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;29:2011-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
13
-
-
75749102647
-
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
-
Roth AD, Tejpar S, Delorenzi M, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol. 2010;28:466-74.
-
(2010)
J Clin Oncol
, vol.28
, pp. 466-474
-
-
Roth, A.D.1
Tejpar, S.2
Delorenzi, M.3
-
14
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359:1757-65.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
15
-
-
79551521053
-
Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
-
Allegra CJ, Yothers G, O'Connell MJ, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol. 2011;29:11-6.
-
(2011)
J Clin Oncol
, vol.29
, pp. 11-16
-
-
Allegra, C.J.1
Yothers, G.2
O'Connell, M.J.3
-
16
-
-
82555177995
-
Microsatellite instability in colorectal cancer: From molecular oncogenic mechanisms to clinical implications
-
Zaanan A, Meunier K, Sangar F, et al. Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications. Cell Oncol. 2011;34:155-76.
-
(2011)
Cell Oncol
, vol.34
, pp. 155-176
-
-
Zaanan, A.1
Meunier, K.2
Sangar, F.3
-
17
-
-
14544300998
-
Systematic review of microsatellite instability and colorectal cancer prognosis
-
DOI 10.1200/JCO.2005.01.086
-
Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 2005;23:609-18. (Pubitemid 46224239)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.3
, pp. 609-618
-
-
Popat, S.1
Hubner, R.2
Houlston, R.S.3
-
18
-
-
10744228074
-
Use of 5-Fluorouracil and Survival in Patients with Microsatellite- Unstable Colorectal Cancer
-
DOI 10.1053/j.gastro.2003.12.023
-
Carethers JM, Smith EJ, Behling CA, et al. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology. 2004;126:394-401. (Pubitemid 38182296)
-
(2004)
Gastroenterology
, vol.126
, Issue.2
, pp. 394-401
-
-
Carethers, J.M.1
Smith, E.J.2
Behling, C.A.3
Nguyen, L.4
Tajima, A.5
Doctolero, R.T.6
Cabrera, B.L.7
Goel, A.8
Arnold, C.A.9
Miyai, K.10
Boland, C.R.11
-
19
-
-
33646798052
-
Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer
-
DOI 10.1136/gut.2005.073015
-
Jover R, Zapater P, Castells A, et al. Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut. 2006;55:848-55. (Pubitemid 43764557)
-
(2006)
Gut
, vol.55
, Issue.6
, pp. 848-855
-
-
Jover, R.1
Zapater, P.2
Castells, A.3
Llor, X.4
Andreu, M.5
Cubiella, J.6
Pinol, V.7
Xicola, R.M.8
Bujanda, L.9
Rene, J.M.10
Clofent, J.11
Bessa, X.12
Morillas, J.D.13
Nicolas-Perez, D.14
Paya, A.15
Alenda, C.16
-
20
-
-
33744818489
-
Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients
-
DOI 10.1200/JCO.2005.03.2433
-
Lanza G, Gafa R, Santini A, et al. Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients. J Clin Oncol. 2006;24:2359-67. (Pubitemid 46630668)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.15
, pp. 2359-2367
-
-
Lanza, G.1
Gafa, R.2
Santini, A.3
Maestri, I.4
Guerzoni, L.5
Cavazzini, L.6
-
21
-
-
33947546541
-
Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-national surgical adjuvant breast and bowel project collaborative study
-
DOI 10.1200/JCO.2006.05.8172
-
Kim GP, Colangelo LH, Wieand HS, et al. Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol. 2007;25:767-72. (Pubitemid 350002875)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.7
, pp. 767-772
-
-
Kim, G.P.1
Colangelo, L.H.2
Wieand, H.S.3
Paik, S.4
Kirsch, I.R.5
Wolmark, N.6
Allegra, C.J.7
-
22
-
-
79953856354
-
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer
-
Hutchins G, Southward K, Handley K, et al. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. J Clin Oncol. 2011;29:1261-70.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1261-1270
-
-
Hutchins, G.1
Southward, K.2
Handley, K.3
-
23
-
-
0034690610
-
Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
-
Elsaleh H, Joseph D, Grieu F, et al. Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet. 2000;355:1745-50. (Pubitemid 30265078)
-
(2000)
Lancet
, vol.355
, Issue.9217
, pp. 1745-1750
-
-
Elsaleh, H.1
Joseph, D.2
Grieu, F.3
Zeps, N.4
Spry, N.5
Iacopetta, B.6
-
24
-
-
0033778049
-
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy
-
Hemminki A, Mecklin JP, Jarvinen H, et al. Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology. 2000;119:921-8.
-
(2000)
Gastroenterology
, vol.119
, pp. 921-928
-
-
Hemminki, A.1
Mecklin, J.P.2
Jarvinen, H.3
-
25
-
-
24944525406
-
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
-
Westra JL, Schaapveld M, Hollema H, et al. Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol. 2005;23:5635-43.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5635-5643
-
-
Westra, J.L.1
Schaapveld, M.2
Hollema, H.3
-
26
-
-
0038002279
-
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
-
DOI 10.1056/NEJMoa022289
-
Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellitein-stability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349:247-57. (Pubitemid 36859476)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.3
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
Thibodeau, S.N.4
French, A.J.5
Goldberg, R.M.6
Hamilton, S.R.7
Laurent-Puig, P.8
Gryfe, R.9
Shepherd, L.E.10
Tu, D.11
Redston, M.12
Gallinger, S.13
-
27
-
-
77954748953
-
Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
-
Sargent DJ, Marsoni S, Monges G, et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol. 2010;28:3219-26.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3219-3226
-
-
Sargent, D.J.1
Marsoni, S.2
Monges, G.3
-
28
-
-
0032993145
-
Mismatch repair proficiency and in vitro response to 5-fluorouracil
-
DOI 10.1016/S0016-5085(99)70558-5
-
Carethers JM, Chauhan DP, Fink D, et al. Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology. 1999;117:123-31. (Pubitemid 29297628)
-
(1999)
Gastroenterology
, vol.117
, Issue.1
, pp. 123-131
-
-
Carethers, J.M.1
Chauhan, D.P.2
Fink, D.3
Nebel, S.4
Bresalier, R.S.5
Howell, S.B.6
Boland, C.R.7
-
29
-
-
79958828886
-
DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy
-
The predictive value of MMR for the beneficial effect of 5-FU might be different according to the molecular mechanism involved in the MSI phenotype (MLH1 promoter methylation vs germline MMR gene mutation)
-
.• Sinicrope FA, Foster NR, Thibodeau SN, et al. DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy. J Natl Cancer Inst. 2011;103:863-75. The predictive value of MMR for the beneficial effect of 5-FU might be different according to the molecular mechanism involved in the MSI phenotype (MLH1 promoter methylation vs germline MMR gene mutation).
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 863-875
-
-
Sinicrope, F.A.1
Foster, N.R.2
Thibodeau, S.N.3
-
30
-
-
2542615200
-
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
-
DOI 10.1056/NEJMoa032709
-
Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350:2343-51. (Pubitemid 38702845)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.23
, pp. 2343-2351
-
-
Andre, T.1
Boni, C.2
Mounedji-Boudiaf, L.3
Navarro, M.4
Tabernero, J.5
Hickish, T.6
Topham, C.7
Zaninelli, M.8
Clingan, P.9
Bridgewater, J.10
Tabah-Fisch, I.11
De Gramont, A.12
-
31
-
-
34250210799
-
Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07
-
DOI 10.1200/JCO.2006.08.2974
-
Kuebler JP, Wieand HS, O'Connell MJ, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol. 2007;25:2198-204. (Pubitemid 46954643)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.16
, pp. 2198-2204
-
-
Kuebler, J.P.1
Wieand, H.S.2
O'Connell, M.J.3
Smith, R.E.4
Colangelo, L.H.5
Yothers, G.6
Petrelli, N.J.7
Findlay, M.P.8
Seay, T.E.9
Atkins, J.N.10
Zapas, J.L.11
Goodwin, J.W.12
Fehrenbacher, L.13
Ramanathan, R.K.14
Conley, B.A.15
Flynn, P.J.16
Soori, G.17
Colman, L.K.18
Levine, E.A.19
Lanier, K.S.20
Wolmark, N.21
more..
-
32
-
-
79955040540
-
Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer
-
Haller DG, Tabernero J, Maroun J, et al. Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer. J Clin Oncol. 2011;29:1465-71.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1465-1471
-
-
Haller, D.G.1
Tabernero, J.2
Maroun, J.3
-
33
-
-
0029904811
-
The role of DNA mismatch repair in platinum drug resistance
-
Fink D, Nebel S, Aebi S, et al. The role of DNA mismatch repair in platinum drug resistance. Cancer Res. 1996;56:4881-6. (Pubitemid 26374423)
-
(1996)
Cancer Research
, vol.56
, Issue.21
, pp. 4881-4886
-
-
Fink, D.1
Nebel, S.2
Aebi, S.3
Zheng, H.4
Cenni, B.5
Nehme, A.6
Christen, R.D.7
Howell, S.B.8
-
34
-
-
78650249084
-
Prognostic impact of microsatellite instability in colorectal cancer patients treated with adjuvant FOLFOX
-
Des Guetz G, Lecaille C, Mariani P, et al. Prognostic impact of microsatellite instability in colorectal cancer patients treated with adjuvant FOLFOX. Anticancer Res. 2010;30:4297-301.
-
(2010)
Anticancer Res
, vol.30
, pp. 4297-4301
-
-
Des Guetz, G.1
Lecaille, C.2
Mariani, P.3
-
35
-
-
77951967408
-
Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin
-
Zaanan A, Cuilliere-Dartigues P, Guilloux A, et al. Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin. Ann Oncol. 2010;21:772-80.
-
(2010)
Ann Oncol
, vol.21
, pp. 772-780
-
-
Zaanan, A.1
Cuilliere-Dartigues, P.2
Guilloux, A.3
-
36
-
-
78149327190
-
Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy
-
Kim ST, Lee J, Park SH, et al. Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy. Cancer Chemother Pharmacol. 2010;66:659-67.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 659-667
-
-
Kim, S.T.1
Lee, J.2
Park, S.H.3
-
37
-
-
82555173112
-
Defective mismatch repair status as a prognostic biomarker of disease-free survival in stage III colon cancer patients treated with adjuvant FOLFOX chemotherapy
-
Zaanan A, Flejou JF, Emile JF, et al. Defective mismatch repair status as a prognostic biomarker of disease-free survival in stage III colon cancer patients treated with adjuvant FOLFOX chemotherapy. Clin Cancer Res. 2011;17:7470-8.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7470-7478
-
-
Zaanan, A.1
Flejou, J.F.2
Emile, J.F.3
-
38
-
-
84870339415
-
Mutation profiling and microsatellite instability in stage II and III colon cancer: An assessment of their prognostic and oxaliplatin predictive value
-
Aworse prognostic impact of BRAF mutation was observed in pMMR and dMMR tumors, although the effect was only significant among pMMR patients
-
.•• Gavin PG, Colangelo LH, Fumagalli D, et al. Mutation profiling and microsatellite instability in stage II and III colon cancer: an assessment of their prognostic and oxaliplatin predictive value. Clin Cancer Res. 2012;18:6531-41. Aworse prognostic impact of BRAF mutation was observed in pMMR and dMMR tumors, although the effect was only significant among pMMR patients.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6531-6541
-
-
Gavin, P.G.1
Colangelo, L.H.2
Fumagalli, D.3
-
41
-
-
84902188016
-
Effect of adding oxaliplatin to adjuvant 5-fluorouracil/leucovorin (5FU/LV) in patients with defective mismatch repair (dMMR) colon cancer stage II and III included in the MOSIAC study
-
The beneficial effect of FOLFOX compared with 5-FU alone in terms of DFS was better in patients with dMMR tumors than in patients with pMMR tumors
-
.• Flejou J-F, André T, Chibaudel B, et al. Effect of adding oxaliplatin to adjuvant 5-fluorouracil/leucovorin (5FU/LV) in patients with defective mismatch repair (dMMR) colon cancer stage II and III included in the MOSIAC study. J Clin Oncol. 2013;31(15 Suppl):3524. The beneficial effect of FOLFOX compared with 5-FU alone in terms of DFS was better in patients with dMMR tumors than in patients with pMMR tumors.
-
(2013)
J Clin Oncol
, vol.31
, Issue.15 SUPPL.
, pp. 3524
-
-
Flejou, J.-F.1
André, T.2
Chibaudel, B.3
-
42
-
-
34548160680
-
Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803
-
DOI 10.1200/JCO.2007.11.2144
-
Saltz LB, Niedzwiecki D, Hollis D, et al. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. J Clin Oncol. 2007;25:3456-61. (Pubitemid 47310883)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.23
, pp. 3456-3461
-
-
Saltz, L.B.1
Niedzwiecki, D.2
Hollis, D.3
Goldberg, R.M.4
Hantel, A.5
Thomas, J.P.6
Fields, A.L.A.7
Mayer, R.J.8
-
43
-
-
67650290547
-
Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3
-
Van Cutsem E, Labianca R, Bodoky G, et al. Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. J Clin Oncol. 2009;27:3117-25.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3117-3125
-
-
Van Cutsem, E.1
Labianca, R.2
Bodoky, G.3
-
44
-
-
64649096900
-
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B protocol 89803
-
Bertagnolli MM, Niedzwiecki D, Compton CC, et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B protocol 89803. J Clin Oncol. 2009;27:1814-21.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1814-1821
-
-
Bertagnolli, M.M.1
Niedzwiecki, D.2
Compton, C.C.3
-
45
-
-
77949274921
-
Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial)
-
Tejpar S, Bosman F, Delorenzi M, et al. Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial). J Clin Oncol. 2009;27(15 Suppl):4001.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
, pp. 4001
-
-
Tejpar, S.1
Bosman, F.2
Delorenzi, M.3
-
46
-
-
84859403854
-
Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: A randomized trial
-
Alberts SR, Sargent DJ, Nair S, et al. Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: a randomized trial. JAMA. 2012;307:1383-93.
-
(2012)
JAMA
, vol.307
, pp. 1383-1393
-
-
Alberts, S.R.1
Sargent, D.J.2
Nair, S.3
-
47
-
-
84870244259
-
Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): A phase 3 randomised controlled trial
-
de Gramont A, Van Cutsem E, Schmoll HJ, et al. Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial. Lancet Oncol. 2012;13:1225-33.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1225-1233
-
-
De Gramont, A.1
Van Cutsem, E.2
Schmoll, H.J.3
-
48
-
-
84868623380
-
LB4. Adjuvant FOLFOX4 with or without cetuximab (CTX) in patients (PTS) with resected stage III colon cancer (CC): DFS and OS results and subgroup analyses of the PETACC8 Intergroup phase III trial
-
Taieb J, Tabernero J, Mini E, et al. LB4. Adjuvant FOLFOX4 with or without cetuximab (CTX) in patients (PTS) with resected stage III colon cancer (CC): DFS and OS results and subgroup analyses of the PETACC8 Intergroup phase III trial. Ann Oncol. 2012;23 Suppl 9:iex9.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
-
-
Taieb, J.1
Tabernero, J.2
Mini, E.3
-
49
-
-
84891619188
-
Prognostic impact of deficient DNA mismatch repair in patients with stage III colon cancer from a randomized trial of FOLFOX-based adjuvant chemotherapy
-
Sinicrope FA, Mahoney MR, Smyrk TC, et al. Prognostic impact of deficient DNA mismatch repair in patients with stage III colon cancer from a randomized trial of FOLFOX-based adjuvant chemotherapy. J Clin Oncol. 2013;31:3664-72.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3664-3672
-
-
Sinicrope, F.A.1
Mahoney, M.R.2
Smyrk, T.C.3
-
50
-
-
84880239195
-
Defective mismatch repair and benefit from bevacizumab for colon cancer: Findings from NSABP C-08
-
Pogue-Geile K, Yothers G, Taniyama Y, et al. Defective mismatch repair and benefit from bevacizumab for colon cancer: findings from NSABP C-08. J Natl Cancer Inst. 2013;105:989-92.
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 989-992
-
-
Pogue-Geile, K.1
Yothers, G.2
Taniyama, Y.3
-
51
-
-
0031013496
-
K-ras mutations and prognosis in large-bowel carcinomas
-
Andersen SN, Lovig T, Breivik J, et al. K-ras mutations and prognosis in large-bowel carcinomas. Scand J Gastroenterol. 1997;32:62-9. (Pubitemid 27026469)
-
(1997)
Scandinavian Journal of Gastroenterology
, vol.32
, Issue.1
, pp. 62-69
-
-
Norheim, A.S.1
Lovig, T.2
Breivik, J.3
Lund, E.4
Gaudernack, G.5
Meling, G.I.6
Rognum, T.O.7
-
52
-
-
73149107502
-
KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
-
Ogino S, Meyerhardt JA, Irahara N, et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin Cancer Res. 2009;15:7322-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7322-7329
-
-
Ogino, S.1
Meyerhardt, J.A.2
Irahara, N.3
-
53
-
-
23944488225
-
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma
-
DOI 10.1136/gut.2005.066514
-
Conlin A, Smith G, Carey FA, et al. The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma. Gut. 2005;54:1283-6. (Pubitemid 41192491)
-
(2005)
Gut
, vol.54
, Issue.9
, pp. 1283-1286
-
-
Conlin, A.1
Smith, G.2
Carey, F.A.3
Wolf, C.R.4
Steele, R.J.C.5
-
54
-
-
0032032984
-
The type of K-ras mutation determines prognosis in colerectal cancer
-
DOI 10.1016/S0002-9610(97)00283-3, PII S0002961097002833
-
Cerottini JP, Caplin S, Saraga E, et al. The type of K-ras mutation determines prognosis in colorectal cancer. Am J Surg. 1998;175:198-202. (Pubitemid 28173710)
-
(1998)
American Journal of Surgery
, vol.175
, Issue.3
, pp. 198-202
-
-
Cerottini, J.-P.1
Caplin, S.2
Saraga, E.3
Givel, J.-C.4
Benhattar, J.5
-
55
-
-
0036739336
-
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype
-
Bazan V, Migliavacca M, Zanna I, et al. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol. 2002;13:1438-46.
-
(2002)
Ann Oncol
, vol.13
, pp. 1438-1446
-
-
Bazan, V.1
Migliavacca, M.2
Zanna, I.3
-
56
-
-
84866450315
-
The prognostic value of KRAS mutations in patients with colorectal cancer
-
Inoue Y, Saigusa S, Iwata T, et al. The prognostic value of KRAS mutations in patients with colorectal cancer. Oncol Rep. 2012;28:1579-84.
-
(2012)
Oncol Rep
, vol.28
, pp. 1579-1584
-
-
Inoue, Y.1
Saigusa, S.2
Iwata, T.3
-
57
-
-
0032490124
-
Kirsten ras mutations in patients with colorectal cancer: The multicenter 'RASCAL' study
-
Andreyev HJ, Norman AR, Cunningham D, et al. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. J Natl Cancer Inst. 1998;90:675-84. (Pubitemid 28222141)
-
(1998)
Journal of the National Cancer Institute
, vol.90
, Issue.9
, pp. 675-684
-
-
Andreyev, H.J.N.1
Norman, A.R.2
Cunningham, D.3
Oates, J.R.4
Clarke, P.A.5
-
58
-
-
0035444798
-
Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study
-
DOI 10.1054/bjoc.2001.1964
-
Andreyev HJ, Norman AR, Cunningham D, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer. 2001;85:692-6. (Pubitemid 32929467)
-
(2001)
British Journal of Cancer
, vol.85
, Issue.5
, pp. 692-696
-
-
Andreyev, H.J.N.1
Norman, A.R.2
Cunningham, D.3
Oates, J.4
Dix, B.R.5
Iacopetta, B.J.6
Young, J.7
Walsh, T.8
Ward, R.9
Hawkins, N.10
Beranek, M.11
Jandik, P.12
Benamouzig, R.13
Jullian, E.14
Laurent-Puig, P.15
Olschwang, S.16
Muller, O.17
Hoffmann, I.18
Rabes, H.M.19
Zietz, C.20
Troungos, C.21
Valavanis, C.22
Yuen, S.T.23
Ho, J.W.C.24
Croke, C.T.25
O'Donoghue, D.P.26
Giaretti, W.27
Rapallo, A.28
Russo, A.29
Bazan, V.30
Tanaka, M.31
Omura, K.32
Azuma, T.33
Ohkusa, T.34
Fujimori, T.35
Ono, Y.36
Pauly, M.37
Faber, C.38
Glaesener, R.39
Goeij, A.F.P.M.D.40
Arends, J.W.41
Andersen, S.N.42
Lovig, T.43
Breivik, J.44
Gaudernack, G.45
Clausen, O.P.F.46
Angelis, P.De.47
Meling, G.I.48
Rognum, T.O.49
Smith, R.50
Goh, H.-S.51
Font, A.52
Rosell, R.53
Sun, X.F.54
Zhang, H.55
Benhattar, J.56
Losi, L.57
Lee, J.Q.58
Wang, S.T.59
Clarke, P.A.60
Bell, S.61
Quirke, P.62
Bubb, V.J.63
Piris, J.64
Cruickshank, N.R.65
Morton, D.66
Fox, J.C.67
Al-Mulla, F.68
Lees, N.69
Hall, C.N.70
Snary, D.71
Wilkinson, K.72
Dillon, D.73
Costa, J.74
Pricolo, V.E.75
Finkelstein, S.D.76
Thebo, J.S.77
Senagore, A.J.78
Halter, S.A.79
Wadler, S.80
Malik, S.81
Krtolica, K.82
Urosevic, N.83
more..
-
59
-
-
69849108427
-
Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges
-
Mandrekar SJ, Sargent DJ. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol. 2009;27:4027-34.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4027-4034
-
-
Mandrekar, S.J.1
Sargent, D.J.2
-
60
-
-
84937156028
-
Overall survival result and outcomes by KRAS, BRAF, and DNA mismatch repair in relation to primary tumor site in colon cancers from a randomized trial of adjuvant chemotherapy: NCCTG (Alliance) N0147
-
Sinicrope FA, Yoon HH, Mahoney MR, et al. Overall survival result and outcomes by KRAS, BRAF, and DNA mismatch repair in relation to primary tumor site in colon cancers from a randomized trial of adjuvant chemotherapy: NCCTG (Alliance) N0147. J Clin Oncol. 2014;32(5 Suppl):3525.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 SUPPL.
, pp. 3525
-
-
Sinicrope, F.A.1
Yoon, H.H.2
Mahoney, M.R.3
-
61
-
-
84901813155
-
KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 Alliance)
-
Yoon HH, Tougeron D, Shi Q, et al. KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 Alliance). Clin Cancer Res. 2014;20:3033-43.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 3033-3043
-
-
Yoon, H.H.1
Tougeron, D.2
Shi, Q.3
-
62
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
Douillard JY, Oliner KS, Siena S, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369:1023-34.
-
(2013)
N Engl J Med
, vol.369
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
-
63
-
-
85028295044
-
Clinicopathologic features of KRAS-mutated colorectal tumors vary by site ofmutation
-
Morris VK, Overman MJ, Eng C, et al. Clinicopathologic features of KRAS-mutated colorectal tumors vary by site ofmutation. J Clin Oncol. 2013;31(15 Suppl):3632.
-
(2013)
J Clin Oncol
, vol.31
, Issue.15 SUPPL.
, pp. 3632
-
-
Morris, V.K.1
Overman, M.J.2
Eng, C.3
-
64
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010;11:753-62.
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
65
-
-
78649473910
-
The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
-
Farina-Sarasqueta A, van Lijnschoten G, Moerland E, et al. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol. 2010;21:2396-402.
-
(2010)
Ann Oncol
, vol.21
, pp. 2396-2402
-
-
Farina-Sarasqueta, A.1
Van Lijnschoten, G.2
Moerland, E.3
-
66
-
-
84856512550
-
Predictive and prognostic roles of BRAF mutation in stage III colon cancer: Results from intergroup trial CALGB 89803
-
Ogino S, Shima K, Meyerhardt JA, et al. Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803. Clin Cancer Res. 2012;18:890-900.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 890-900
-
-
Ogino, S.1
Shima, K.2
Meyerhardt, J.A.3
-
67
-
-
84862244596
-
Identification of a poorprognosis BRAF-mutant-like population of patients with colon cancer
-
Popovici V, Budinska E, Tejpar S, et al. Identification of a poorprognosis BRAF-mutant-like population of patients with colon cancer. J Clin Oncol. 2012;30:1288-95.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1288-1295
-
-
Popovici, V.1
Budinska, E.2
Tejpar, S.3
-
68
-
-
22244472992
-
Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
-
Samowitz WS, Sweeney C, Herrick J, et al. Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res. 2005;65:6063-9.
-
(2005)
Cancer Res
, vol.65
, pp. 6063-6069
-
-
Samowitz, W.S.1
Sweeney, C.2
Herrick, J.3
-
69
-
-
84867705940
-
Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers
-
Bond CE, Umapathy A, Buttenshaw RL, et al. Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers. PLoS One. 2012;7:e47483.
-
(2012)
PLoS One
, vol.7
-
-
Bond, C.E.1
Umapathy, A.2
Buttenshaw, R.L.3
-
70
-
-
50349091081
-
Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer
-
French AJ, Sargent DJ, Burgart LJ, et al. Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer. Clin Cancer Res. 2008;14:3408-15.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3408-3415
-
-
French, A.J.1
Sargent, D.J.2
Burgart, L.J.3
-
71
-
-
84881640407
-
Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication
-
Lochhead P, Kuchiba A, Imamura Y, et al. Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J Natl Cancer Inst. 2013;105:1151-6.
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 1151-1156
-
-
Lochhead, P.1
Kuchiba, A.2
Imamura, Y.3
-
72
-
-
67650315187
-
Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
-
Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol. 2009;27:3109-16.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3109-3116
-
-
Andre, T.1
Boni, C.2
Navarro, M.3
|